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Nitazoxanide
From WikEM
Contents
Administration
- Type: Antiparasitic, active against giardia and cryptosporidium
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 500mg PO BID x 3 days
Pediatric Dosing
- 1-3yo: 100mg BID x 3 days
- 4-11yo: 200mg BID x 3 days
- >11yo: 500mg BID x 3 days
Special Populations
- Pregnancy Rating: B
- Lactation risk: infant risk cannot be ruled out
- Renal dosing:
- Hepatic dosing:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
- Abdominal pain, nausea
- Headache
- Abnormal color of urine
Pharmacology
- Half-life: 1-1.6h
- Metabolism:
- Excretion: Mostly fecal
Mechanism of Action
- inhibits pyruvate ferredoxin oxidoreductase, which is essential to anaerobic energy metabolism
