Opioids

Types of Opioids

DRUG	TYPICAL ADULT DOSE	PHARMACOKINETICS	COMMENTS
Morphine	0.1 mg/kg IV 10mg IM 0.3 mg/kg PO	Onset: 1-2 min (IV), 10-15 min (IM/SC) Peak effect: 3-5 min (IV), 15-30 min (IM) Duration: 1-2 h (IV), 3-4 h (IM/SC)	Histamine release may produce transient hypotension or nausea and emesis, neither require routine adjunctive treatment
Hydromorphone (Dilaudid)	0.015 mg/kg IV 1-2 mg IM	Onset: 3-5 min (IV) Peak effect: 7-10 min (IV) Duration: 2-4 h (IV)
Fentanyl	1.0 mcg/kg IV	Onset: <1 min (IV) Peak effect: 2-5 min (IV) Duration: 30-60 min (IV)	High doses can cause chest wall rigidity (>5 mcg/kg IV)
Meperidine (Demerol)	1.0-1.5 mg/kg IV/IM	Onset: 5 min (IV) Peak effect: 5-10 min (IV) Duraction 2-3 h (IV)	Contraindicated when patient taking a MAOI Neurotoxicity occur when multiple doses given in the presence of renal failure
Oxycodone	5-10 mg PO 30 mg PR	Onset: 10-15 min (PO) Duration 3-6 h (PO)	Possible inadvertent acetaminophen overdose with combination agents
Hydrocodone	5-10 mg PO	Onset: 30-60 min (PO) Duraction 4-6 h (PO)	Lower incidence of nausea Possible inadvertent acetaminophen overdose with combination agents
Codeine	30-60 mg PO 30-100 mg IM	Onset: 30-60 min (PO) Duraction: 4-6 h (PO)	High incidence of GI side effects Some patients cannot convert to codeine-6-glucuronide and morphine Possible inadvertent acetaminophen overdose with combination agents
Tramadol (Ultram)	50-100 mg PO	Onset: 10-15 min (PO) Duration: 4-6 h (PO)	Central nervous system side effects

DRUG	ROUTE	DOSAGE	COMMENTS
Morphine	IV or IM	Titrate 2-5 mg increments q5-10 min Peak analgesia in 10-20 min Average: 10 mg q3-4h	Preferred first-line agent in most situations
Fentanyl	IV or IM	Titrate 25-50 mcg increments q2-3 min Peak analgesia in 3-5 min Duration 30-60 min	Ideal for short procedures No histamine release Typically not suitable for the ED
Meperidine (Demerol)	IV	Titrate 12.5-50 mg increments Peak analgesia in 5-10 min Average: 100 mg q2-3h	Risk of unique CNS toxicity with repeated dosing IM injection is very irritating to tissue
Hydromorphone (Dilaudid)	IV	Titrate 0.5-1.0 mg increments Peak analgesia in 5-15 min Average: 1.5 mg q3-4h
Butorphanol (Stadol)	IV	Titrate 0.5-2.0 mg increments Peak analgesia in 4-5 min Average: 2 mg q3-4h	Mixed agonist-antagonist May be preferred in biliary colic

DRUG	ANALGESIC EQUIVALENCE	USUAL STARTING DOSE	USUAL INTERVAL
Morphine (MSIR, Roxanol, others)	30 mg	15-30 mg	3-4 h
Morphine: sustained release (MS Contin, Oramorph-SR)	30 mg	30 mg	8-12 h
Meperidine (Demerol)	300 mg	50-100 mg	2-3 h
Codeine (in Tylenol #3, others)	200 mg	30-60 mg	3-4 h
Oxycodone (Roxicodone, also in Percocet, Percodan, Tylox, others)	20-30 mg	5-10 mg	3-6 h
Hydrocodone (in Lorcet, Lortab, Vicodin, others)	30 mg	5-10 mg	3-6 h
Hydromorphone (Dilaudid)	7.5 mg	4-8 mg	2-3 h
Tramadol (Ultram)	N/A	25-50 mg	4-6 h