Oxycodone

General

• Type: opioid
• Dosage Forms: PO
• Common Trade Names: Roxicodone, Oxycontin

Adult Dosing

General Pain

• 5-15mg PO q4-6h

Pediatric Dosing

General Pain

• 0.05-0.15mg/kg PO q4-6h prn
• Max: 5mg/dose

Special Populations

• Pregnancy Rating: C
• Lactation Risk Categories: possibly unsafe
• Renal Dosing
  • Adult: CrCl < 60: decrease starting dose
  • Pediatric: CrCl 10-50: decrease starting dose 25%, CrCL < 10: decrease dose 50%
• Hepatic Dosing
  • Adult: not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Respiratory Depression
• Apnea
• syncope
• bradycardia
• Seizures
• anaphylaxis

Common

• Nausea
• Rash
• Headache
• Fatigue
• xerostomia
• constipation
• Tremor
• transaminitis

Pharmacology

• Half-life: 3.5-4 hour
• Metabolism: Liver
• Excretion: urine
• Mechanism of Action:binds to various opioid receptors

Authors

Babak Missaghi, Colin Hoff, Ross Donaldson, Daniel Ostermayer, Neil Young