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Oxybutynin
From WikEM
Contents
Administration
- Type: Antispasmodic, urinary
- Dosage Forms: 5mg
- Routes of Administration: Oral
- Common Trade Names: Oxybutynin chloride
Adult Dosing
- 5mg 2-3 times daily, maximum 5mg 4 times daily
Pediatric Dosing
- > 5 years and adolescent
- 5mg twice daily, maximum 5mg 3 times daily
Geriatric Dosing
- 2.5mg 2-3 times daily, increase cautiously
Special Populations
- Pregnancy Rating: B
- Lactation risk: Not defined, use with caution when administered to a nursing woman
Renal Dosing
- Adult: Not defined
- Pediatric: Not defined
Hepatic Dosing
- Adult: Not defined
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
- Risk of narrow-angle glaucoma
- Risk of urinary retention
- Risk of gastric retention or severely decreased gastric motility
Adverse Reactions
Serious
- Arrhythmia (sinus)
- Hypotension
- Hypertension
Common
- Dizziness
- Drowsiness
- Xerostomia (dose-related)
- Constipation
- Nausea
- Headache
- Nervousness
- Insomnia
- Urinary hesitancy
- Urinary retention
- Urinary tract infection
- Blurred vision
Pharmacology
- Half-life: 2-3 h
- Metabolism: Liver
- Excretion: Urine
Mechanism of Action
- Direct antispasmodic effect on smooth muscle
- Inhibit action of acetylcholine on smooth muscle; decreased frequency and urgent
