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P450
From WikEM
Contents
Background
Antimicrobials
Avoid /P450 Inhibitors
- Quinolones, especially levofloxacin
- Macrolides, especially erythromycin
- Bactrim and sulfonamides
- Flagyl
- Nafcillin, oxacillin
Use
SignificantP450 Inhibitors in General
- Grapefruit juice
- Valproate
- INH
- Protease inhibitors (-navir, i.e. ritonavir)
- SSRIs, except escitalopram
- Amiodarone
- Fluoroquinolones
- Sulfonamides
- Macrolides
- Cimetidine
- Omeprazole
- Ketoconazole
- Acute EtOH
SignificantP450 Inducers in General
- Phenytoin
- Carbamazepine
- Ethosuximide
- Quinidine/quinine
- Rifampin
- Griseofulvin
- Glucocorticoids
- Barbituates
- St. John's wort
- Chronic EtOH
- Tobacco smoking
