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Peramivir
From WikEM
Contents
Administration
- Type: Antiviral active against influenza
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names:
Adult Dosing
- Uncomplicated influenza: 600mg IV as single dose
- Influenza requiring hospitalization: 600mg IV daily or 300mg IV BID for 5-10 days
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing
- CrCl 30-50: 150-200mg IV daily
- CrCl 10-30: 100mg IV daily
- CrCl <10: 100 mg IV on day 1, followed by 15 mg IV daily on subsequent days
- Hepatic dosing: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- SJS
- Anaphylaxis
- Abnormal behavior, hallucinations
Common
- Diarrhea
Pharmacology
- Half-life: 20h
- Metabolism:
- Excretion: Mostly renal
Mechanism of Action
- Inhibits neuraminidase activity of influenza A and B
