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Pregabalin
From WikEM
Contents
Administration
- Type: GABA analog, analgesic
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Lyrica
Adult Dosing
- 50-200mg PO TID
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C (though fetal risk has been demonstrated)
- Lactation risk: Infant risk has been demonstrated
- Renal dosing: reduce dose per manufacturer/FDA guidelines
- Hepatic dosing:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Angioedema, hypersensitivity reaction
- Jaundice
- Elevated creatine kinase level
- Suicidal thoughts
Common
- Constipation, xerostomia, weight gain
- Peripheral edema
- Dizziness, ataxia, somnolence, blurred vision, headache
- Nasopharyngitis
- Disturbance in thinking, euphoria
Pharmacology
- Half-life: 6.3h
- Metabolism:
- Excretion: Mostly renal
Mechanism of Action
- GABA-analog, exact mechanism of analgesic effect poorly understood
