Ranitidine

General

• Type: H2 blocker
• Dosage Forms: 75, 150, 300
• Common Trade Names: Zantac

Adult Dosing

GERD: 150mg PO BID

Pediatric Dosing

GERD: 5-10mg/kg/day PO BID

Special Populations

• Pregnancy Rating: B
• Lactation: Probably Safe
• Renal Dosing
  • Adult: CrCl < 50: 150mg Qday; CrCl < 10: 75 -150mg Qday; HD: give dose after dialysis
  • Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
• Hepatic Dosing
  • Adult: Not defined
  • Pediatric: not defined

Contraindications

• Allergy to class/drug
• Porphyria
• Caution if impairment of liver or kidneys
• Caution in chronic pulmonary disease
• Caution if diabetes mellitus
• Caution if immunocompromised

Adverse Reactions

Serious

• Thrombocytopenia
• Hepatotoxicity
• Pneumonia

Common

• Nausea/vomiting/diarrhea
• Fatigue
• Headache
• Rash
• Myalgia
• Xerostomia

Pharmacology

• Half-life: 2-3 hr, Renal impairment: 5 hr
• Metabolism: Liver
• Excretion: Urine, Feces
• Mechanism of Action: H2 blocker

References

Authors

Babak Missaghi, Ross Donaldson, Aaron Snyder, Neil Young, Daniel Ostermayer