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Rasburicase
From WikEM
Contents
Administration
- Type: Enzyme
- Dosage Forms:
- Routes of Administration: IV
- Common Trade Names: Elitek
Adult Dosing
- Hyperuricemia due to tumor lysis syndrome: 0.2 mg/kg IV over 30 minutes daily for up to 5 days
Pediatric Dosing
- 0.2 mg/kg IV over 30 minutes daily for up to 5 days
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing:
- Hepatic dosing:
Contraindications
- Allergy to class/drug
- G6PD deficiency
- History of hemolytic reaction to rasburicase or any excipients
- History of methemoglobinemia reaction to rasburicase or any excipients
Adverse Reactions
Serious
- Dysrhythmia, MI, heart failure, cardiac arrest
- Bowel obstruction
- Severe diarrhea, dehydration
- Methemoglobinemia
- Neutropenia, hemolysis, thrombocytopenia, pancytopenia
- Hemorrhage, thrombosis
- Sepsis
- Stroke
- Renal failure
- Pulmonary edema, pulmonary hypertension, pneumonia, respiratory distress
- Fever (severe), rigors
Common
- Fever
- Rash
- Diarrhea, nausea/vomiting, constipation, abdominal pain
- Mucous membrane inflammation
- Headache
Pharmacology
- Half-life: 18h
- Metabolism: liver
- Excretion:
Mechanism of Action
- Enzyme catalyzes oxidation of uric acid into inactive and soluble metabolite
