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Succimer
From WikEM
Contents
Administration
- Type: Antidote
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- Lead poisoning: 10 to 30 mg/kg/day for 5 days
Pediatric Dosing
Safety/efficacy not established in patients <12mo
- Lead poisoning, level >45 mcg/dL: 10 mg/kg or 350 mg/m(2) q8h for 5 days, then q12 h for 14 days
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: administer with caution, ensure adequate hydration
- Hepatic dosing: no adjustment, monitor LFTs closely
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Neutropenia
Common
- Rash
- Nausea/vomiting, diarrhea, decreased appetite
- Elevated transaminases
Pharmacology
- Half-life: 48h
- Metabolism:
- Excretion: Renal 25%
Mechanism of Action
- Forms stable, water-soluble complexes with lead, leading to increased urinary excretion
