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Template:Pertussis Antibiotics
From WikEM
- Antibiotics do not help with severity or duration but may decrease infectivity.
- A reasonable guideline is to treat persons aged >1 year within 3 weeks of cough onset and infants aged <1 year and pregnant women (especially near term) within 6 weeks of cough onset. [1]
- TMP--SMZ should not be administered to pregnant women, nursing mothers, or infants aged <2 months.[2]
- The following regemins are for active disease or postexposure prophylaxis. If a patient is has confirmed disease and is likely to be in contact with infants or pregnant women then the patient should be treated as up to 6-8 weeks after the onset of their illness.
< 1 month old
Same antibiotics for active disease and postexposure prophylaxis
- Azithromycin 10mg/kg (max 500mg/day) daily x 5 days
>1 month old
- Azithromycin 10mg/kg (max 500mg/day) daily x 5 days
- if > 6 months old then day 2-5 of treatment should be reduced to 5mg/kg (250mg/day max)
- TMP/SMX 4mg/kg PO BID daily for 14 days (if > 2 months old)
Adults
andy of the following antibiotics are acceptable although azithromycin is most commonly prescribed
- Azithromycin 500mg PO once daily for day #1 then 250mg PO once daily for days #2-5
- Clarithromycin 500mg BID x7 days
- Erythromycin 500mg QID x7 days
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