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Triazolam
From WikEM
Contents
Administration
- Type: Benzodiazepine
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Halcion
Adult Dosing
- 0.25-0.5mg PO qHS
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: X
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: 0.125 mg PO qHS
Contraindications
- Allergy to class/drug
- Concomitant use of potent CYP 3A inhibitors (e.g. itraconazole, ketoconazole, nefazodone, protease-inhibitors)
- Pregnancy
Adverse Reactions
Serious
- Respiratory depression, apnea
- Liver failure, cholestatic jaundice syndrome
- Amnesia, abnormal behavior, worsening depression, suicidal thoughts
- Dystonia
- Paradoxical excitability
- Drug dependence, withdrawal
Common
- Somnolence
- Dizziness, lightheadedness
- Nervousness
- Headache
Pharmacology
- Half-life: 1.5-5h
- Metabolism: Hepatic, via CYP3A
- Excretion: Renal
Mechanism of Action
- Triazolobenzodiazepine, GABA-receptor agonist
