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Valganciclovir
From WikEM
Contents
Administration
- Type: Antiviral
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- CMV infection: 900 mg PO BID
- CMV prophylaxis: 900 mg PO daily
Pediatric Dosing
- Neonatal CMV infection: 17 mg/kg PO daily BID x 12 weeks, then 17 mg/kg daily until 1 year of age
Special Populations
- Pregnancy Rating: Fetal risk cannot be ruled out
- Lactation risk: infant risk cannot be ruled out
- Renal dosing
- CrCl 40-59 mL/min: 450 mg BID
- CrCl 25-39 mL/min: 450 mg once daily
- CrCl 10-24 mL/min: 450 mg every 2 days
- CrCl < 10 mL/min or on HD: not recommended
- Hepatic dosing:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Anemia/aplastic anemia, leukopenia, thrombocytopenia, pancytopenia
Common
- Nausea/vomiting, diarrhea
- Graft rejection
- Headache
- URI
- UTI
- Fever
- Tremor
Pharmacology
- Half-life: 4-10h
- Metabolism: Hepatic
- Excretion: Renal
Mechanism of Action
- Inhibits viral DNA synthesis
