Valganciclovir

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Administration

  • Type: Antiviral
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names:

Adult Dosing

  • CMV infection: 900 mg PO BID
  • CMV prophylaxis: 900 mg PO daily

Pediatric Dosing

  • Neonatal CMV infection: 17 mg/kg PO daily BID x 12 weeks, then 17 mg/kg daily until 1 year of age

Special Populations

  • Pregnancy Rating: Fetal risk cannot be ruled out
  • Lactation risk: infant risk cannot be ruled out
  • Renal dosing
    • CrCl 40-59 mL/min: 450 mg BID
    • CrCl 25-39 mL/min: 450 mg once daily
    • CrCl 10-24 mL/min: 450 mg every 2 days
    • CrCl < 10 mL/min or on HD: not recommended
  • Hepatic dosing:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Anemia/aplastic anemia, leukopenia, thrombocytopenia, pancytopenia

Common

  • Nausea/vomiting, diarrhea
  • Graft rejection
  • Headache
  • URI
  • UTI
  • Fever
  • Tremor

Pharmacology

  • Half-life: 4-10h
  • Metabolism: Hepatic
  • Excretion: Renal

Mechanism of Action

  • Inhibits viral DNA synthesis

Comments

See Also

References

Authors

Claire