Aspergillosis Risk & Prevention

The different types of aspergillosis affect different groups of people.1

  • Allergic bronchopulmonary aspergillosis (ABPA) most often occurs in people who have cystic fibrosis or asthma.
  • Aspergillomas usually affect people who have other lung diseases like tuberculosis.
  • Chronic pulmonary aspergillosis typically occurs in people who have other lung diseases, including tuberculosis, chronic obstructive pulmonary disease (COPD), or sarcoidosis.2
  • Invasive aspergillosis affects people who have weakened immune systems, such as people who have had a stem cell transplant or organ transplant, are getting chemotherapy for cancer, or are taking high doses of corticosteroids.

References

  1. Barnes PD, Marr KA. Aspergillosis: spectrum of disease, diagnosis, and treatment. Infect Dis Clin North Am. 2006 Sep;20(3):545-61, vi.
  2. Schweer KE, Bangard C, Hekmat K, Cornely OA. Chronic pulmonary aspergillosis. Mycoses. 2014 May;57(5):257-70.
  3. Avery RK, Michaels MG. Strategies for safe living after solid organ transplantation. Am J Transplant. 2013 Mar;13 Suppl 4:304-10.
  4. CDC. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR. 2000 Oct;49(RR-10):1-125, CE1-7.
  5. Brizendine KD, Vishin S, Baddley JW. Antifungal prophylaxis in solid organ transplant recipients. Expert Rev Anti Infect Ther. 2011 May;9(5):571-81.
  6. Rogers TR, Slavin MA, Donnelly JP. Antifungal prophylaxis during treatment for haematological malignancies: are we there yet? Br J Haemato. 2011 Jun;153(6):681-97.
  7. Maertens J, Van Eldere J, Verhaegen J, Verbeken E, Verschakelen J, Boogaerts M. Use of circulating galactomannan screening for early diagnosis of invasive aspergillosis in allogeneic stem cell transplant recipients. J Infect Dis. 2002 Nov 1;186(9):1297-306.
  8. Lackner M1, Lass-Flörl C. Up-date on diagnostic strategies of invasive aspergillosis. Curr Pharm Design 2013;19(20):3595-614.
  9. Weber DJ et al. Preventing healthcare-associated Aspergillus infections: a review of recent CDC/HICPAC recommendations. Med Mycol 2009; 47S1: S199-209.
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