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CCR2 Allele and Genotype Frequencies

This website is archived for historical purposes and is no longer being maintained or updated.

Available polymorphism(s)

Common Designations

rs number

 Nucleotide change Amino acid change

Genotyping method

rs1799864

 Ex2+241G>A Val64Ile TaqMan

 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs1799864 A G AA AG GG
Non-Hispanic White 9.5 (8.1, 11.1) 90.5 (88.9, 91.9) <0.001 1.2 (0.6, 2.2) 16.5 (14.1, 19.3) 82.3 (79.4, 84.8) <0.001 0.34
Non-Hispanic Black 14.5 (13.6, 15.4) 85.5 (84.6, 86.4) 1.7 (1.1, 2.4) 25.7 (24.0, 27.4) 72.7 (71.0, 74.3) 0.06
Mexican American 21.7 (19.8, 23.7) 78.3 (76.3, 80.2) 4.5 (3.3, 6.2) 34.4 (32.1, 36.6) 61.1 (58.2, 63.9) 0.74
Total* 11.2 (10.1, 12.6) 88.8 (87.4, 89.9) 1.6 (1.0, 2.4) 19.3 (17.4, 21.4) 79.1 (76.9, 81.2)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1799864 A G AA AG GG
12-19 12.7 (10.6, 15.1) 87.3 (84.9, 89.4) 0.043 0.8 (0.4, 1.5) 23.8 (19.7, 28.5) 75.4 (70.7, 79.6) 0.066
20-39 12.0 (10.3, 13.9) 88.0 (86.1, 89.7) 2.2 (1.2, 3.9) 19.7 (17.1, 22.6) 78.2 (75.1, 80.9)
40-59 9.9 (8.4, 11.8) 90.1 (88.2, 91.6) 1.4 (0.7, 2.6) 17.2 (14.6, 20.0) 81.5 (78.4, 84.2)
>=60 10.6 (9.2, 12.2) 89.4 (87.8, 90.8) 1.3 (0.7, 2.6) 18.5 (16.3, 21.0) 80.1 (77.5, 82.6)
Total 11.2 (10.1, 12.6) 88.8 (87.4, 89.9) 1.6 (1.0, 2.4) 19.3 (17.4, 21.4) 79.1 (76.9, 81.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1799864 A G AA AG GG
Male 10.7 (9.4, 12.0) 89.3 (88.0, 90.6) 0.422 1.8 (1.1, 3.2) 17.6 (15.4, 20.2) 80.5 (78.1, 82.7) 0.227
Female 11.8 (9.6, 14.3) 88.2 (85.7, 90.4) 1.3 (0.9, 2.1) 20.9 (17.2, 25.1) 77.8 (73.2, 81.8)
Total 11.2 (10.1, 12.6) 88.8 (87.4, 89.9) 1.6 (1.0, 2.4) 19.3 (17.4, 21.4) 79.1 (76.9, 81.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs1799864 A G AA AG GG
Non-Hispanic White 12-19 10.3 (7.8, 13.6) 89.7 (86.4, 92.2) 0.4 (0.1, 2.3) 19.8 (15.0, 25.6) 79.8 (73.7, 84.7)
20-39 9.4 (7.4, 11.8) 90.6 (88.2, 92.6) 1.5 (0.6, 3.9) 15.8 (12.4, 19.9) 82.7 (78.5, 86.2)
40-59 9.1 (7.2, 11.4) 90.9 (88.6, 92.8) 1.2 (0.5, 3.0) 15.8 (12.6, 19.5) 83.0 (79.0, 86.4)
>=60 9.7 (8.0, 11.6) 90.3 (88.4, 92.0) 1.1 (0.5, 2.8) 17.0 (14.6, 19.8) 81.8 (78.7, 84.6)
Non-Hispanic Black 12-19 14.0 (11.9, 16.4) 86.0 (83.6, 88.1) 1.2 (0.4, 3.7) 25.6 (21.9, 29.8) 73.2 (69.0, 77.0)
20-39 15.2 (13.8, 16.8) 84.8 (83.2, 86.2) 2.0 (1.3, 3.1) 26.5 (23.8, 29.4) 71.5 (68.6, 74.2)
40-59 13.2 (10.9, 16.0) 86.8 (84.0, 89.1) 1.4 (0.5, 3.9) 23.6 (19.7, 28.1) 75.0 (70.2, 79.1)
>=60 15.1 (12.2, 18.5) 84.9 (81.5, 87.8) 1.7 (0.8, 3.4) 26.9 (21.5, 32.9) 71.5 (65.3, 77.0)
Mexican American 12-19 19.5 (15.8, 23.8) 80.5 (76.2, 84.2) 3.5 (2.0, 6.1) 32.0 (25.2, 39.7) 64.5 (56.8, 71.5)
20-39 23.6 (21.4, 26.1) 76.4 (73.9, 78.6) 5.1 (3.5, 7.4) 37.1 (34.6, 39.8) 57.8 (54.5, 61.0)
40-59 20.9 (18.2, 23.9) 79.1 (76.1, 81.8) 4.9 (2.3, 10.0) 32.0 (27.0, 37.4) 63.1 (58.9, 67.2)
>=60 17.7 (13.9, 22.2) 82.3 (77.8, 86.1) 3.0 (1.4, 6.4) 29.3 (22.8, 36.9) 67.6 (60.0, 74.5)

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs1799864 A G AA AG GG
Non-Hispanic White Male 8.9 (7.3, 10.9) 91.1 (89.1, 92.7) 1.6 (0.8, 3.4) 14.6 (11.8, 17.9) 83.8 (80.5, 86.6)
Female 10.0 (7.7, 12.8) 90.0 (87.2, 92.3) 0.8 (0.4, 1.5) 18.4 (14.1, 23.6) 80.8 (75.5, 85.3)
Non-Hispanic Black Male 13.6 (12.1, 15.3) 86.4 (84.7, 87.9) 1.3 (0.9, 2.1) 24.5 (21.7, 27.5) 74.1 (71.0, 77.0)
Female 15.2 (14.0, 16.5) 84.8 (83.5, 86.0) 1.9 (1.2, 3.0) 26.6 (24.1, 29.2) 71.5 (69.0, 73.8)
Mexican American Male 20.7 (18.3, 23.4) 79.3 (76.6, 81.7) 4.0 (2.2, 7.2) 33.5 (30.5, 36.6) 62.5 (59.0, 66.0)
Female 22.8 (20.7, 25.1) 77.2 (74.9, 79.3) 5.1 (3.7, 7.1) 35.3 (32.7, 38.0) 59.6 (56.3, 62.7)

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