CXCL12 Allele and Genotype Frequencies

Available polymorphism(s)

	Common Designations
rs number	Nucleotide change	Amino acid change	Genotyping method
rs169097	Ex5+709C>T		MGB Eclipse

 

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By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs169097		C	T		CC	CT	TT
	Non-Hispanic White	99.7 (99.4, 99.8)	0.3 (0.2, 0.6)	<0.001	99.4 (98.9, 99.7)	0.6 (0.3, 1.1)	0.0 (0.0, 0.1)	<0.001	<0.01
	Non-Hispanic Black	82.8 (80.7, 84.8)	17.2 (15.2, 19.3)		68.4 (64.7, 71.9)	28.9 (25.7, 32.4)	2.7 (1.9, 3.8)		0.46
	Mexican American	99.0 (98.6, 99.4)	1.0 (0.6, 1.4)		98.1 (97.1, 98.7)	1.9 (1.3, 2.9)	0.0 (NA)		0.61
	Total*	97.5 (96.8, 98.1)	2.5 (1.9, 3.2)		95.4 (94.1, 96.4)	4.3 (3.4, 5.5)	0.3 (0.2, 0.5)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs169097		C	T		CC	CT	TT
	12-19	96.4 (95.0, 97.4)	3.6 (2.6, 5.0)	0.001	93.2 (90.6, 95.1)	6.4 (4.5, 8.9)	0.4 (0.2, 0.9)	0.013
	20-39	97.3 (96.2, 98.1)	2.7 (1.9, 3.8)		95.0 (93.0, 96.5)	4.5 (3.2, 6.4)	0.5 (0.3, 0.8)
	40-59	97.9 (97.3, 98.4)	2.1 (1.6, 2.7)		96.0 (94.9, 96.9)	3.8 (2.9, 4.9)	0.2 (0.1, 0.4)
	>=60	98.3 (97.6, 98.8)	1.7 (1.2, 2.4)		96.7 (95.4, 97.6)	3.2 (2.4, 4.4)	0.1 (0.0, 0.4)
	Total	97.5 (96.8, 98.1)	2.5 (1.9, 3.2)		95.4 (94.1, 96.4)	4.3 (3.4, 5.5)	0.3 (0.2, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs169097		C	T		CC	CT	TT
	Male	97.6 (96.9, 98.1)	2.4 (1.9, 3.1)	0.716	95.5 (94.3, 96.5)	4.1 (3.2, 5.2)	0.4 (0.2, 0.7)	0.434
	Female	97.5 (96.6, 98.1)	2.5 (1.9, 3.4)		95.2 (93.6, 96.4)	4.5 (3.3, 6.1)	0.3 (0.2, 0.4)
	Total	97.5 (96.8, 98.1)	2.5 (1.9, 3.2)		95.4 (94.1, 96.4)	4.3 (3.4, 5.5)	0.3 (0.2, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs169097			C	T	CC	CT	TT
	Non-Hispanic White	12-19	99.3 (97.5, 99.8)	0.7 (0.2, 2.5)	98.6 (95.0, 99.6)	1.4 (0.4, 5.0)	0.0 (NA)
		20-39	99.9 (99.4, 100.0)	0.1 (0.0, 0.6)	99.8 (98.8, 100.0)	0.2 (0.0, 1.2)	0.0 (NA)
		40-59	99.6 (99.3, 99.8)	0.4 (0.2, 0.7)	99.2 (98.5, 99.6)	0.7 (0.3, 1.5)	0.1 (0.0, 0.5)
		>=60	99.8 (99.3, 99.9)	0.2 (0.1, 0.7)	99.6 (98.7, 99.9)	0.4 (0.1, 1.3)	0.0 (NA)
	Non-Hispanic Black	12-19	82.4 (79.1, 85.3)	17.6 (14.7, 20.9)	67.5 (62.0, 72.6)	29.7 (25.0, 34.9)	2.8 (1.5, 5.1)
		20-39	82.2 (78.7, 85.3)	17.8 (14.7, 21.3)	68.2 (62.6, 73.4)	28.0 (23.6, 32.8)	3.8 (2.4, 6.0)
		40-59	84.0 (81.0, 86.6)	16.0 (13.4, 19.0)	69.5 (63.7, 74.8)	29.0 (23.7, 35.0)	1.5 (0.9, 2.5)
		>=60	83.4 (79.7, 86.5)	16.6 (13.5, 20.3)	68.0 (61.6, 73.7)	30.8 (25.3, 37.0)	1.2 (0.3, 4.8)
	Mexican American	12-19	98.4 (97.4, 99.1)	1.6 (0.9, 2.6)	96.9 (94.8, 98.2)	3.1 (1.8, 5.2)	0.0 (NA)
		20-39	99.1 (98.1, 99.6)	0.9 (0.4, 1.9)	98.2 (96.3, 99.2)	1.8 (0.8, 3.7)	0.0 (NA)
		40-59	99.2 (98.8, 99.5)	0.8 (0.5, 1.2)	98.4 (97.6, 99.0)	1.6 (1.0, 2.4)	0.0 (NA)
		>=60	99.6 (99.0, 99.8)	0.4 (0.2, 1.0)	99.1 (98.0, 99.6)	0.9 (0.4, 2.0)	0.0 (NA)

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By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs169097			C	T	CC	CT	TT
	Non-Hispanic White	Male	99.6 (99.3, 99.8)	0.4 (0.2, 0.7)	99.3 (98.7, 99.6)	0.7 (0.3, 1.3)	0.0 (0.0, 0.3)
		Female	99.8 (99.3, 99.9)	0.2 (0.1, 0.7)	99.6 (98.7, 99.9)	0.4 (0.1, 1.3)	0.0 (NA)
	Non-Hispanic Black	Male	82.6 (79.9, 85.0)	17.4 (15.0, 20.1)	68.4 (63.9, 72.5)	28.4 (24.5, 32.7)	3.2 (1.9, 5.3)
		Female	83.1 (80.7, 85.2)	16.9 (14.8, 19.3)	68.4 (64.1, 72.3)	29.4 (25.6, 33.5)	2.2 (1.6, 3.2)
	Mexican American	Male	98.8 (97.9, 99.3)	1.2 (0.7, 2.1)	97.5 (95.9, 98.6)	2.5 (1.4, 4.1)	0.0 (NA)
		Female	99.3 (98.7, 99.6)	0.7 (0.4, 1.3)	98.6 (97.5, 99.3)	1.4 (0.7, 2.5)	0.0 (NA)

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