CYP1A2 Allele and Genotype Frequencies
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Available polymorphism(s)
| Common Designations | |||
|---|---|---|---|
|
rs number |
Nucleotide change | Amino acid change |
Genotyping method |
|
rs11854147 |
5341bp 3′ of STP C>T | TaqMan | |
|
rs2069514 |
-3859G>A | TaqMan | |
|
rs4886406 |
9773bp 3′ of STP T>G | TaqMan | |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs11854147 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 68.6 (66.9, 70.4) | 31.4 (29.6, 33.1) | <0.001 | 49.1 (46.9, 51.4) | 39.0 (37.2, 40.8) | 11.9 (10.3, 13.6) | <0.001 | <0.01 | |
| Non-Hispanic Black | 27.9 (26.1, 29.7) | 72.1 (70.3, 73.9) | 8.6 (7.1, 10.4) | 38.6 (36.8, 40.5) | 52.8 (50.5, 55.1) | 0.11 | |||
| Mexican American | 38.7 (35.1, 42.3) | 61.3 (57.7, 64.9) | 16.5 (13.3, 20.2) | 44.4 (41.0, 47.8) | 39.1 (34.8, 43.7) | 0.11 | |||
| Total* | 59.6 (57.2, 61.9) | 40.4 (38.1, 42.8) | 39.5 (36.8, 42.2) | 40.1 (38.6, 41.7) | 20.4 (18.2, 22.7) | ||||
| rs2069514 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 1.6 (1.0, 2.5) | 98.4 (97.5, 99.0) | <0.001 | 0.1 (0.0, 0.8) | 2.9 (1.8, 4.7) | 96.9 (95.2, 98.1) | <0.001 | 0.09 | |
| Non-Hispanic Black | 26.3 (24.9, 27.7) | 73.7 (72.3, 75.1) | 6.3 (5.3, 7.5) | 39.9 (36.8, 43.1) | 53.8 (51.0, 56.5) | 0.29 | |||
| Mexican American | 33.7 (30.2, 37.4) | 66.3 (62.6, 69.8) | 12.2 (9.3, 15.9) | 42.9 (39.3, 46.6) | 44.9 (40.3, 49.6) | 0.29 | |||
| Total* | 8.4 (7.0, 10.0) | 91.6 (90.0, 93.0) | 2.2 (1.7, 2.9) | 12.4 (10.2, 15.0) | 85.4 (82.6, 87.9) | ||||
| rs4886406 | G | T | GG | GT | TT | ||||
| Non-Hispanic White | 27.8 (26.5, 29.2) | 72.2 (70.8, 73.5) | <0.001 | 8.4 (7.1, 9.8) | 38.9 (37.1, 40.8) | 52.7 (50.9, 54.6) | 0.001 | 0.13 | |
| Non-Hispanic Black | 38.3 (36.0, 40.8) | 61.7 (59.2, 64.0) | 13.9 (12.1, 16.0) | 48.8 (45.9, 51.8) | 37.2 (33.8, 40.8) | 0.18 | |||
| Mexican American | 26.5 (24.7, 28.5) | 73.5 (71.5, 75.3) | 7.2 (5.8, 9.0) | 38.6 (36.2, 41.1) | 54.1 (51.4, 56.9) | 0.87 | |||
| Total* | 29.4 (28.1, 30.7) | 70.6 (69.3, 71.9) | 9.0 (7.9, 10.2) | 40.9 (38.9, 42.9) | 50.1 (48.1, 52.2) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs11854147 | C | T | CC | CT | TT | |||
| 12-19 | 57.9 (51.7, 63.9) | 42.1 (36.1, 48.3) | 0.199 | 37.8 (30.9, 45.3) | 40.2 (35.8, 44.7) | 22.0 (16.8, 28.3) | 0.252 | |
| 20-39 | 58.1 (54.8, 61.4) | 41.9 (38.6, 45.2) | 37.0 (33.3, 40.8) | 42.3 (40.2, 44.4) | 20.7 (17.8, 24.1) | |||
| 40-59 | 60.6 (57.4, 63.7) | 39.4 (36.3, 42.6) | 41.5 (37.5, 45.5) | 38.3 (35.1, 41.5) | 20.3 (17.5, 23.4) | |||
| >=60 | 62.1 (59.6, 64.5) | 37.9 (35.5, 40.4) | 42.9 (39.8, 46.0) | 38.5 (35.5, 41.6) | 18.6 (16.1, 21.4) | |||
| Total | 59.6 (57.2, 61.9) | 40.4 (38.1, 42.8) | 39.5 (36.8, 42.2) | 40.1 (38.6, 41.7) | 20.4 (18.2, 22.7) | |||
| rs2069514 | A | G | AA | AG | GG | |||
| 12-19 | 10.5 (7.9, 13.9) | 89.5 (86.1, 92.1) | 0.003 | 3.1 (2.2, 4.4) | 14.9 (10.8, 20.2) | 82.0 (76.2, 86.6) | 0.062 | |
| 20-39 | 9.7 (7.4, 12.6) | 90.3 (87.4, 92.6) | 2.4 (1.5, 3.8) | 14.6 (10.7, 19.5) | 83.1 (77.9, 87.2) | |||
| 40-59 | 7.4 (6.1, 8.9) | 92.6 (91.1, 93.9) | 2.2 (1.5, 3.2) | 10.4 (8.7, 12.5) | 87.4 (85.0, 89.4) | |||
| >=60 | 5.8 (4.5, 7.6) | 94.2 (92.4, 95.5) | 1.3 (0.6, 2.9) | 9.0 (7.5, 10.7) | 89.7 (87.2, 91.7) | |||
| Total | 8.4 (7.0, 10.0) | 91.6 (90.0, 93.0) | 2.2 (1.7, 2.9) | 12.4 (10.2, 15.0) | 85.4 (82.6, 87.9) | |||
| rs4886406 | G | T | GG | GT | TT | |||
| 12-19 | 28.7 (25.2, 32.5) | 71.3 (67.5, 74.8) | 0.822 | 8.8 (5.4, 14.1) | 39.8 (34.5, 45.4) | 51.4 (46.6, 56.1) | 0.966 | |
| 20-39 | 30.0 (27.9, 32.2) | 70.0 (67.8, 72.1) | 9.1 (7.4, 11.2) | 41.8 (39.3, 44.4) | 49.1 (46.0, 52.1) | |||
| 40-59 | 29.2 (26.9, 31.7) | 70.8 (68.3, 73.1) | 9.1 (6.8, 12.1) | 40.2 (36.1, 44.4) | 50.7 (47.1, 54.2) | |||
| >=60 | 28.9 (26.8, 31.1) | 71.1 (68.9, 73.2) | 8.5 (7.3, 9.9) | 40.8 (37.2, 44.5) | 50.7 (46.9, 54.5) | |||
| Total | 29.4 (28.1, 30.7) | 70.6 (69.3, 71.9) | 9.0 (7.9, 10.2) | 40.9 (38.9, 42.9) | 50.1 (48.1, 52.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs11854147 | C | T | CC | CT | TT | |||
| Male | 59.5 (56.5, 62.5) | 40.5 (37.5, 43.5) | 0.975 | 39.4 (36.1, 42.8) | 40.3 (37.3, 43.3) | 20.3 (17.2, 23.8) | 0.995 | |
| Female | 59.6 (56.9, 62.2) | 40.4 (37.8, 43.1) | 39.6 (35.8, 43.4) | 40.0 (37.1, 43.1) | 20.4 (18.5, 22.4) | |||
| Total | 59.6 (57.2, 61.9) | 40.4 (38.1, 42.8) | 39.5 (36.8, 42.2) | 40.1 (38.6, 41.7) | 20.4 (18.2, 22.7) | |||
| rs2069514 | A | G | AA | AG | GG | |||
| Male | 8.9 (7.0, 11.3) | 91.1 (88.7, 93.0) | 0.166 | 2.4 (1.7, 3.5) | 13.0 (10.1, 16.6) | 84.6 (80.5, 88.0) | 0.391 | |
| Female | 7.9 (6.8, 9.1) | 92.1 (90.9, 93.2) | 2.0 (1.6, 2.6) | 11.8 (10.0, 14.0) | 86.2 (83.9, 88.1) | |||
| Total | 8.4 (7.0, 10.0) | 91.6 (90.0, 93.0) | 2.2 (1.7, 2.9) | 12.4 (10.2, 15.0) | 85.4 (82.6, 87.9) | |||
| rs4886406 | G | T | GG | GT | TT | |||
| Male | 29.2 (27.0, 31.6) | 70.8 (68.4, 73.0) | 0.819 | 8.7 (7.0, 10.7) | 41.2 (38.1, 44.3) | 50.2 (46.7, 53.6) | 0.845 | |
| Female | 29.6 (28.0, 31.2) | 70.4 (68.8, 72.0) | 9.2 (8.1, 10.5) | 40.7 (37.0, 44.5) | 50.1 (46.8, 53.4) | |||
| Total | 29.4 (28.1, 30.7) | 70.6 (69.3, 71.9) | 9.0 (7.9, 10.2) | 40.9 (38.9, 42.9) | 50.1 (48.1, 52.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs11854147 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 70.6 (65.2, 75.4) | 29.4 (24.6, 34.8) | 52.2 (44.3, 59.9) | 36.8 (29.8, 44.4) | 11.0 (7.5, 15.9) | |
| 20-39 | 68.3 (65.3, 71.2) | 31.7 (28.8, 34.7) | 48.2 (44.5, 51.9) | 40.3 (37.3, 43.4) | 11.5 (8.9, 14.7) | ||
| 40-59 | 68.5 (65.6, 71.3) | 31.5 (28.7, 34.4) | 49.2 (45.8, 52.7) | 38.6 (35.4, 41.9) | 12.2 (9.4, 15.6) | ||
| >=60 | 68.2 (66.5, 69.9) | 31.8 (30.1, 33.5) | 49.0 (46.2, 51.8) | 38.5 (34.8, 42.2) | 12.6 (10.6, 14.9) | ||
| Non-Hispanic Black | 12-19 | 24.8 (20.3, 29.9) | 75.2 (70.1, 79.7) | 6.3 (4.4, 9.0) | 36.9 (30.2, 44.3) | 56.7 (48.4, 64.6) | |
| 20-39 | 29.5 (27.1, 32.0) | 70.5 (68.0, 72.9) | 9.9 (7.5, 13.1) | 39.2 (35.7, 42.7) | 50.9 (47.7, 54.1) | ||
| 40-59 | 25.9 (23.3, 28.7) | 74.1 (71.3, 76.7) | 7.8 (5.3, 11.4) | 36.3 (32.1, 40.7) | 55.9 (52.1, 59.7) | ||
| >=60 | 30.6 (24.8, 37.2) | 69.4 (62.8, 75.2) | 8.8 (6.1, 12.5) | 43.6 (34.2, 53.5) | 47.5 (37.1, 58.2) | ||
| Mexican American | 12-19 | 37.2 (32.9, 41.6) | 62.8 (58.4, 67.1) | 15.1 (9.9, 22.3) | 44.2 (37.5, 51.1) | 40.7 (35.9, 45.7) | |
| 20-39 | 37.3 (34.1, 40.7) | 62.7 (59.3, 65.9) | 14.9 (12.6, 17.6) | 44.9 (40.8, 49.0) | 40.2 (35.5, 45.1) | ||
| 40-59 | 43.2 (35.9, 50.8) | 56.8 (49.2, 64.1) | 22.1 (15.3, 30.9) | 42.2 (36.3, 48.4) | 35.6 (27.7, 44.4) | ||
| >=60 | 38.3 (34.2, 42.6) | 61.7 (57.4, 65.8) | 14.6 (11.6, 18.1) | 47.6 (41.6, 53.6) | 37.9 (31.6, 44.6) | ||
| rs2069514 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 2.0 (0.8, 5.2) | 98.0 (94.8, 99.2) | 0.2 (0.0, 1.9) | 3.5 (1.2, 9.9) | 96.2 (90.0, 98.6) | |
| 20-39 | 1.7 (0.7, 4.1) | 98.3 (95.9, 99.3) | 0.0 (NA) | 3.3 (1.3, 8.2) | 96.7 (91.8, 98.7) | ||
| 40-59 | 1.2 (0.7, 2.2) | 98.8 (97.8, 99.3) | 0.4 (0.0, 2.9) | 1.7 (0.9, 3.2) | 97.9 (96.7, 98.7) | ||
| >=60 | 1.8 (1.3, 2.4) | 98.2 (97.6, 98.7) | 0.0 (NA) | 3.5 (2.7, 4.7) | 96.5 (95.3, 97.3) | ||
| Non-Hispanic Black | 12-19 | 30.5 (27.2, 34.1) | 69.5 (65.9, 72.8) | 8.8 (6.0, 12.6) | 43.6 (37.7, 49.7) | 47.7 (42.1, 53.3) | |
| 20-39 | 24.9 (22.7, 27.3) | 75.1 (72.7, 77.3) | 5.2 (3.5, 7.7) | 39.4 (34.2, 44.8) | 55.4 (50.9, 59.9) | ||
| 40-59 | 27.2 (24.3, 30.4) | 72.8 (69.6, 75.7) | 7.5 (5.5, 10.2) | 39.4 (34.3, 44.8) | 53.1 (47.9, 58.2) | ||
| >=60 | 23.2 (20.1, 26.7) | 76.8 (73.3, 79.9) | 4.3 (2.2, 8.2) | 37.9 (31.3, 44.9) | 57.8 (51.6, 63.8) | ||
| Mexican American | 12-19 | 34.5 (27.5, 42.3) | 65.5 (57.7, 72.5) | 14.4 (9.0, 22.1) | 40.3 (31.9, 49.3) | 45.3 (35.3, 55.7) | |
| 20-39 | 34.3 (31.9, 36.7) | 65.7 (63.3, 68.1) | 11.8 (9.4, 14.8) | 44.8 (41.7, 48.1) | 43.3 (40.4, 46.3) | ||
| 40-59 | 32.5 (27.6, 37.9) | 67.5 (62.1, 72.4) | 10.5 (6.6, 16.4) | 43.9 (39.2, 48.8) | 45.5 (39.2, 52.0) | ||
| >=60 | 31.1 (25.6, 37.3) | 68.9 (62.7, 74.4) | 13.7 (9.6, 19.1) | 34.9 (28.5, 41.9) | 51.4 (43.2, 59.6) | ||
| rs4886406 | G | T | GG | GT | TT | ||
| Non-Hispanic White | 12-19 | 26.6 (22.2, 31.4) | 73.4 (68.6, 77.8) | 7.9 (4.9, 12.5) | 37.3 (30.4, 44.7) | 54.8 (47.4, 62.0) | |
| 20-39 | 28.5 (26.1, 31.1) | 71.5 (68.9, 73.9) | 8.8 (6.6, 11.6) | 39.4 (36.5, 42.3) | 51.8 (48.5, 55.1) | ||
| 40-59 | 27.9 (25.3, 30.7) | 72.1 (69.3, 74.7) | 8.4 (5.6, 12.5) | 39.0 (34.5, 43.7) | 52.6 (48.8, 56.3) | ||
| >=60 | 27.3 (25.3, 29.3) | 72.7 (70.7, 74.7) | 7.8 (6.5, 9.4) | 38.9 (35.3, 42.6) | 53.3 (49.7, 56.8) | ||
| Non-Hispanic Black | 12-19 | 34.5 (31.1, 38.1) | 65.5 (61.9, 68.9) | 9.0 (7.0, 11.3) | 51.1 (44.0, 58.1) | 40.0 (33.5, 46.9) | |
| 20-39 | 37.2 (34.4, 40.0) | 62.8 (60.0, 65.6) | 13.6 (11.2, 16.4) | 47.1 (43.5, 50.8) | 39.3 (35.4, 43.4) | ||
| 40-59 | 41.6 (37.2, 46.1) | 58.4 (53.9, 62.8) | 17.1 (12.9, 22.3) | 48.9 (43.3, 54.6) | 34.0 (28.5, 40.0) | ||
| >=60 | 41.4 (36.2, 46.8) | 58.6 (53.2, 63.8) | 15.8 (10.3, 23.5) | 51.1 (42.9, 59.3) | 33.1 (26.5, 40.3) | ||
| Mexican American | 12-19 | 26.0 (22.9, 29.5) | 74.0 (70.5, 77.1) | 7.8 (5.7, 10.6) | 36.5 (30.9, 42.5) | 55.7 (49.9, 61.4) | |
| 20-39 | 27.5 (24.9, 30.2) | 72.5 (69.8, 75.1) | 8.0 (5.7, 11.1) | 39.0 (36.3, 41.7) | 53.0 (49.7, 56.3) | ||
| 40-59 | 24.5 (21.2, 28.1) | 75.5 (71.9, 78.8) | 5.0 (3.3, 7.6) | 38.9 (32.6, 45.6) | 56.0 (49.6, 62.3) | ||
| >=60 | 27.6 (24.4, 31.0) | 72.4 (69.0, 75.6) | 6.9 (4.4, 10.7) | 41.2 (37.0, 45.6) | 51.8 (47.2, 56.4) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs11854147 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 68.5 (65.2, 71.6) | 31.5 (28.4, 34.8) | 48.7 (44.6, 52.9) | 39.6 (36.1, 43.1) | 11.7 (9.0, 15.1) | |
| Female | 68.8 (66.9, 70.6) | 31.2 (29.4, 33.1) | 49.5 (46.4, 52.6) | 38.4 (35.1, 41.9) | 12.0 (10.4, 13.9) | ||
| Non-Hispanic Black | Male | 27.7 (25.2, 30.3) | 72.3 (69.7, 74.8) | 9.2 (7.6, 11.1) | 36.9 (33.4, 40.5) | 53.9 (49.8, 57.9) | |
| Female | 28.1 (25.3, 31.1) | 71.9 (68.9, 74.7) | 8.0 (5.8, 11.0) | 40.1 (37.8, 42.4) | 51.9 (48.2, 55.5) | ||
| Mexican American | Male | 39.4 (35.6, 43.2) | 60.6 (56.8, 64.4) | 17.4 (14.1, 21.3) | 43.9 (39.4, 48.5) | 38.7 (33.7, 43.9) | |
| Female | 37.9 (33.7, 42.4) | 62.1 (57.6, 66.3) | 15.4 (11.7, 20.1) | 44.9 (41.6, 48.3) | 39.6 (34.6, 44.9) | ||
| rs2069514 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 2.1 (1.1, 4.0) | 97.9 (96.0, 98.9) | 0.2 (0.0, 1.8) | 3.7 (1.9, 7.1) | 96.1 (92.6, 97.9) | |
| Female | 1.1 (0.7, 1.9) | 98.9 (98.1, 99.3) | 0.1 (0.0, 0.4) | 2.2 (1.3, 3.7) | 97.8 (96.3, 98.7) | ||
| Non-Hispanic Black | Male | 26.3 (24.7, 28.0) | 73.7 (72.0, 75.3) | 6.4 (4.8, 8.4) | 39.8 (36.1, 43.7) | 53.8 (50.7, 56.8) | |
| Female | 26.2 (24.3, 28.2) | 73.8 (71.8, 75.7) | 6.2 (4.9, 8.0) | 40.0 (35.5, 44.7) | 53.7 (49.8, 57.7) | ||
| Mexican American | Male | 32.7 (28.6, 37.1) | 67.3 (62.9, 71.4) | 11.5 (8.4, 15.5) | 42.4 (38.2, 46.6) | 46.1 (40.5, 51.9) | |
| Female | 34.7 (31.0, 38.6) | 65.3 (61.4, 69.0) | 13.0 (9.6, 17.3) | 43.5 (38.5, 48.6) | 43.6 (38.4, 48.8) | ||
| rs4886406 | G | T | GG | GT | TT | ||
| Non-Hispanic White | Male | 27.5 (24.7, 30.5) | 72.5 (69.5, 75.3) | 7.7 (5.8, 10.3) | 39.6 (36.5, 42.8) | 52.7 (48.6, 56.7) | |
| Female | 28.1 (26.5, 29.7) | 71.9 (70.3, 73.5) | 9.0 (7.8, 10.2) | 38.3 (34.4, 42.3) | 52.8 (49.4, 56.1) | ||
| Non-Hispanic Black | Male | 38.8 (35.6, 42.1) | 61.2 (57.9, 64.4) | 14.1 (12.0, 16.6) | 49.4 (44.5, 54.3) | 36.5 (31.5, 41.9) | |
| Female | 38.0 (35.0, 41.0) | 62.0 (59.0, 65.0) | 13.8 (11.5, 16.4) | 48.4 (44.7, 52.1) | 37.8 (33.6, 42.3) | ||
| Mexican American | Male | 26.7 (23.5, 30.2) | 73.3 (69.8, 76.5) | 6.6 (4.8, 9.0) | 40.2 (36.4, 44.2) | 53.2 (48.0, 58.3) | |
| Female | 26.4 (24.4, 28.5) | 73.6 (71.5, 75.6) | 7.9 (6.2, 10.0) | 37.0 (34.4, 39.6) | 55.1 (52.2, 58.0) | ||
- Page last reviewed: March 16, 2009 (archived document)
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