CYP2E1 Allele and Genotype Frequencies

Available polymorphism(s)

	Common Designations
rs number	Nucleotide change	Amino acid change	Genotyping method
rs2031920	-1054C>T -1053C>T		MGB Eclipse

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By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs2031920		C	T		CC	CT	TT
	Non-Hispanic White	97.8 (97.0, 98.3)	2.2 (1.7, 3.0)	<0.001	95.6 (94.2, 96.8)	4.2 (3.1, 5.8)	0.1 (0.0, 0.4)	<0.001	0.16
	Non-Hispanic Black	99.2 (98.9, 99.5)	0.8 (0.5, 1.1)		98.5 (97.8, 98.9)	1.5 (1.1, 2.2)	0.0 (NA)		0.73
	Mexican American	89.3 (88.2, 90.4)	10.7 (9.6, 11.8)		79.7 (77.4, 81.8)	19.3 (16.9, 21.9)	1.0 (0.5, 2.0)		0.61
	Total*	96.9 (96.2, 97.4)	3.1 (2.6, 3.8)		94.0 (92.7, 95.0)	5.8 (4.8, 7.0)	0.3 (0.1, 0.5)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs2031920		C	T		CC	CT	TT
	12-19	96.7 (95.4, 97.6)	3.3 (2.4, 4.6)	0.718	93.9 (91.0, 95.9)	5.7 (3.5, 9.2)	0.5 (0.1, 2.1)	0.246
	20-39	96.6 (95.2, 97.6)	3.4 (2.4, 4.8)		93.6 (91.1, 95.4)	6.1 (4.4, 8.3)	0.4 (0.1, 1.1)
	40-59	97.1 (96.1, 97.9)	2.9 (2.1, 3.9)		94.3 (92.2, 95.9)	5.6 (4.1, 7.7)	0.1 (0.0, 0.1)
	>=60	97.0 (95.8, 97.9)	3.0 (2.1, 4.2)		94.3 (92.1, 95.9)	5.5 (4.0, 7.5)	0.2 (0.0, 0.9)
	Total	96.9 (96.2, 97.4)	3.1 (2.6, 3.8)		94.0 (92.7, 95.0)	5.8 (4.8, 7.0)	0.3 (0.1, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs2031920		C	T		CC	CT	TT
	Male	96.6 (95.6, 97.3)	3.4 (2.7, 4.4)	0.252	93.5 (91.6, 95.0)	6.1 (4.6, 8.0)	0.4 (0.2, 0.9)	0.206
	Female	97.1 (96.3, 97.7)	2.9 (2.3, 3.7)		94.3 (92.8, 95.6)	5.5 (4.3, 7.1)	0.1 (0.0, 0.7)
	Total	96.9 (96.2, 97.4)	3.1 (2.6, 3.8)		94.0 (92.7, 95.0)	5.8 (4.8, 7.0)	0.3 (0.1, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs2031920			C	T	CC	CT	TT
	Non-Hispanic White	12-19	97.5 (96.5, 98.2)	2.5 (1.8, 3.5)	95.5 (92.7, 97.3)	3.9 (1.8, 8.4)	0.5 (0.1, 3.6)
		20-39	98.0 (96.4, 98.9)	2.0 (1.1, 3.6)	96.0 (92.9, 97.8)	4.0 (2.2, 7.1)	0.0 (NA)
		40-59	97.8 (96.6, 98.6)	2.2 (1.4, 3.4)	95.7 (93.3, 97.3)	4.3 (2.7, 6.7)	0.0 (NA)
		>=60	97.4 (96.3, 98.2)	2.6 (1.8, 3.7)	95.0 (93.0, 96.5)	4.7 (3.3, 6.8)	0.2 (0.0, 1.1)
	Non-Hispanic Black	12-19	99.3 (98.5, 99.7)	0.7 (0.3, 1.5)	98.6 (97.0, 99.4)	1.4 (0.6, 3.0)	0.0 (NA)
		20-39	99.3 (98.9, 99.5)	0.7 (0.5, 1.1)	98.6 (97.9, 99.1)	1.4 (0.9, 2.1)	0.0 (NA)
		40-59	99.1 (98.2, 99.6)	0.9 (0.4, 1.8)	98.3 (96.3, 99.2)	1.7 (0.8, 3.7)	0.0 (NA)
		>=60	99.2 (97.4, 99.7)	0.8 (0.3, 2.6)	98.3 (94.8, 99.5)	1.7 (0.5, 5.2)	0.0 (NA)
	Mexican American	12-19	90.4 (88.4, 92.1)	9.6 (7.9, 11.6)	82.1 (79.3, 84.6)	16.6 (14.3, 19.2)	1.3 (0.4, 4.3)
		20-39	88.4 (87.1, 89.6)	11.6 (10.4, 12.9)	77.7 (75.1, 80.2)	21.4 (18.5, 24.5)	0.9 (0.3, 2.7)
		40-59	90.5 (87.3, 92.9)	9.5 (7.1, 12.7)	82.2 (76.7, 86.6)	16.6 (12.6, 21.7)	1.2 (0.4, 3.5)
		>=60	89.6 (86.0, 92.3)	10.4 (7.7, 14.0)	79.7 (72.6, 85.3)	19.8 (14.1, 27.1)	0.5 (0.2, 1.8)

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By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs2031920			C	T	CC	CT	TT
	Non-Hispanic White	Male	97.4 (96.4, 98.2)	2.6 (1.8, 3.6)	95.1 (93.0, 96.6)	4.6 (3.1, 6.9)	0.2 (0.1, 0.8)
		Female	98.1 (97.4, 98.6)	1.9 (1.4, 2.6)	96.1 (94.7, 97.2)	3.9 (2.8, 5.3)	0.0 (NA)
	Non-Hispanic Black	Male	99.2 (98.6, 99.6)	0.8 (0.4, 1.4)	98.5 (97.2, 99.2)	1.5 (0.8, 2.8)	0.0 (NA)
		Female	99.2 (98.7, 99.6)	0.8 (0.4, 1.3)	98.5 (97.4, 99.1)	1.5 (0.9, 2.6)	0.0 (NA)
	Mexican American	Male	88.9 (87.4, 90.3)	11.1 (9.7, 12.6)	79.4 (76.6, 82.0)	19.0 (16.3, 22.0)	1.6 (0.8, 3.0)
		Female	89.8 (88.4, 91.0)	10.2 (9.0, 11.6)	80.0 (77.1, 82.7)	19.5 (16.7, 22.7)	0.4 (0.2, 1.1)

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