F2 Allele and Genotype Frequencies

Available polymorphism(s)

	Common Designations
rs number	Nucleotide change	Amino acid change	Genotyping method
rs1799963	Ex14-1G>A		Pyrosequencing

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By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs1799963		A	G		AA	AG	GG
	Non-Hispanic White	1.1 (0.8, 1.7)	98.9 (98.3, 99.2)	0.001	0 (NA)	2.3 (1.5, 3.4)	97.7 (96.6, 98.5)	0.001	0.51
	Non-Hispanic Black	0.3 (0.1, 0.5)	99.7 (99.5, 99.9)		0 (NA)	0.5 (0.3, 1.1)	99.5 (98.9, 99.7)		0.88
	Mexican American	1.1 (0.7, 1.7)	98.9 (98.3, 99.3)		0 (NA)	2.2 (1.5, 3.4)	97.8 (96.6, 98.5)		0.63
	Total*	1.0 (0.7, 1.3)	99.0 (98.7, 99.3)		0 (NA)	1.9 (1.4, 2.7)	98.1 (97.3, 98.6)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1799963		A	G		AA	AG	GG
	12-19	0.8 (0.4, 1.6)	99.2 (98.4, 99.6)	0.080	0 (NA)	1.5 (0.7, 3.2)	98.5 (96.8, 99.3)	0.103
	20-39	0.6 (0.3, 1.2)	99.4 (98.8, 99.7)		0 (NA)	1.2 (0.6, 2.4)	98.8 (97.6, 99.4)
	40-59	1.3 (0.8, 2.2)	98.7 (97.8, 99.2)		0 (NA)	2.7 (1.6, 4.5)	97.3 (95.5, 98.4)
	>=60	1.3 (0.9, 1.8)	98.7 (98.2, 99.1)		0 (NA)	2.5 (1.8, 3.6)	97.5 (96.4, 98.2)
	Total	1.0 (0.7, 1.3)	99.0 (98.7, 99.3)		0 (NA)	1.9 (1.4, 2.7)	98.1 (97.3, 98.6)

* Includes all participants, regardless of race/ethnicity.

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By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1799963		A	G		AA	AG	GG
	Male	0.9 (0.6, 1.3)	99.1 (98.7, 99.4)	0.611	0 (NA)	1.8 (1.2, 2.7)	98.2 (97.3, 98.8)	0.618
	Female	1.0 (0.7, 1.6)	99.0 (98.4, 99.3)		0 (NA)	2.0 (1.3, 3.1)	98.0 (96.9, 98.7)
	Total	1.0 (0.7, 1.3)	99.0 (98.7, 99.3)		0 (NA)	1.9 (1.4, 2.7)	98.1 (97.3, 98.6)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs1799963			A	G	AA	AG	GG
	Non-Hispanic White	12-19	1.0 (0.4, 2.1)	99.0 (97.9, 99.6)	0 (NA)	1.9 (0.8, 4.2)	98.1 (95.8, 99.2)
		20-39	0.7 (0.3, 1.6)	99.3 (98.4, 99.7)	0 (NA)	1.4 (0.6, 3.2)	98.6 (96.8, 99.4)
		40-59	1.6 (0.9, 2.8)	98.4 (97.2, 99.1)	0 (NA)	3.2 (1.8, 5.6)	96.8 (94.4, 98.2)
		>=60	1.4 (1.0, 2.1)	98.6 (97.9, 99.0)	0 (NA)	2.8 (1.9, 4.1)	97.2 (95.9, 98.1)
	Non-Hispanic Black	12-19	0.3 (0.1, 1.2)	99.7 (98.8, 99.9)	0 (NA)	0.6 (0.2, 2.4)	99.4 (97.6, 99.8)
		20-39	0.3 (0.1, 0.8)	99.7 (99.2, 99.9)	0 (NA)	0.5 (0.2, 1.6)	99.5 (98.4, 99.8)
		40-59	0.2 (0.1, 0.8)	99.8 (99.2, 99.9)	0 (NA)	0.4 (0.1, 1.6)	99.6 (98.4, 99.9)
		>=60	0.3 (0.1, 1.0)	99.7 (99.0, 99.9)	0 (NA)	0.5 (0.1, 2.1)	99.5 (97.9, 99.9)
	Mexican American	12-19	0.9 (0.3, 2.7)	99.1 (97.3, 99.7)	0 (NA)	1.8 (0.6, 5.4)	98.2 (94.6, 99.4)
		20-39	1.2 (0.7, 2.0)	98.8 (98.0, 99.3)	0 (NA)	2.4 (1.4, 3.9)	97.6 (96.1, 98.6)
		40-59	1.0 (0.5, 1.9)	99.0 (98.1, 99.5)	0 (NA)	2.0 (1.1, 3.7)	98.0 (96.3, 98.9)
		>=60	1.4 (0.6, 3.6)	98.6 (96.4, 99.4)	0 (NA)	2.9 (1.1, 7.2)	97.1 (92.8, 98.9)

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By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs1799963			A	G	AA	AG	GG
	Non-Hispanic White	Male	1.1 (0.7, 1.7)	98.9 (98.3, 99.3)	0 (NA)	2.2 (1.4, 3.5)	97.8 (96.5, 98.6)
		Female	1.2 (0.7, 1.9)	98.8 (98.1, 99.3)	0 (NA)	2.3 (1.4, 3.8)	97.7 (96.2, 98.6)
	Non-Hispanic Black	Male	0.2 (0.0, 0.6)	99.8 (99.4, 100.0)	0 (NA)	0.3 (0.1, 1.2)	99.7 (98.8, 99.9)
		Female	0.4 (0.2, 0.7)	99.6 (99.3, 99.8)	0 (NA)	0.7 (0.4, 1.4)	99.3 (98.6, 99.6)
	Mexican American	Male	0.8 (0.5, 1.2)	99.2 (98.8, 99.5)	0 (NA)	1.6 (1.0, 2.4)	98.4 (97.6, 99.0)
		Female	1.4 (0.8, 2.5)	98.6 (97.5, 99.2)	0 (NA)	2.9 (1.7, 5.0)	97.1 (95.0, 98.3)

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