FGB Allele and Genotype Frequencies
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Available polymorphism(s)
|
rs number |
Common Designations
Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs1800790 |
-462G>A |
TaqMan |
|
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1800790 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 19.4 (18.1, 20.7) | 80.6 (79.3, 81.9) | <0.001 | 3.4 (2.6, 4.5) | 31.9 (30.1, 33.8) | 64.6 (62.6, 66.6) | <0.001 | 0.81 | |
| Non-Hispanic Black | 5.5 (4.6, 6.6) | 94.5 (93.4, 95.4) | 0.6 (0.3, 1.3) | 9.8 (8.0, 11.9) | 89.6 (87.5, 91.3) | 0.01 | |||
| Mexican American | 15.0 (13.5, 16.6) | 85.0 (83.4, 86.5) | 2.5 (2.0, 3.1) | 24.9 (22.3, 27.8) | 72.6 (69.6, 75.4) | 0.82 | |||
| Total* | 17.6 (16.2, 19.1) | 82.4 (80.9, 83.8) | 3.3 (2.4, 4.4) | 28.7 (26.8, 30.7) | 68.0 (65.7, 70.2) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1800790 | A | G | AA | AG | GG | |||
| 12-19 | 17.0 (13.8, 20.8) | 83.0 (79.2, 86.2) | 0.357 | 3.3 (1.8, 5.9) | 27.5 (22.3, 33.4) | 69.2 (62.9, 74.9) | 0.163 | |
| 20-39 | 18.3 (16.3, 20.5) | 81.7 (79.5, 83.7) | 3.0 (2.0, 4.5) | 30.6 (28.0, 33.3) | 66.4 (63.1, 69.6) | |||
| 40-59 | 16.4 (14.2, 18.8) | 83.6 (81.2, 85.8) | 3.1 (2.1, 4.5) | 26.6 (22.4, 31.3) | 70.3 (65.8, 74.5) | |||
| >=60 | 18.5 (17.1, 20.0) | 81.5 (80.0, 82.9) | 4.0 (2.8, 5.7) | 29.0 (26.7, 31.3) | 67.0 (64.7, 69.2) | |||
| Total | 17.6 (16.2, 19.1) | 82.4 (80.9, 83.8) | 3.3 (2.4, 4.4) | 28.7 (26.8, 30.7) | 68.0 (65.7, 70.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1800790 | A | G | AA | AG | GG | |||
| Male | 18.0 (16.4, 19.8) | 82.0 (80.2, 83.6) | 0.447 | 3.4 (2.4, 4.8) | 29.3 (26.7, 32.1) | 67.3 (64.4, 70.1) | 0.709 | |
| Female | 17.3 (15.5, 19.2) | 82.7 (80.8, 84.5) | 3.2 (2.1, 4.8) | 28.2 (26.1, 30.4) | 68.6 (65.9, 71.3) | |||
| Total | 17.6 (16.2, 19.1) | 82.4 (80.9, 83.8) | 3.3 (2.4, 4.4) | 28.7 (26.8, 30.7) | 68.0 (65.7, 70.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1800790 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 20.4 (15.7, 26.1) | 79.6 (73.9, 84.3) | 3.9 (1.9, 7.8) | 33.0 (25.4, 41.6) | 63.1 (53.8, 71.6) | |
| 20-39 | 19.9 (18.2, 21.8) | 80.1 (78.2, 81.8) | 2.8 (2.0, 4.1) | 34.2 (31.4, 37.0) | 63.0 (59.8, 66.0) | ||
| 40-59 | 18.0 (15.7, 20.5) | 82.0 (79.5, 84.3) | 3.3 (2.2, 5.0) | 29.4 (25.2, 34.0) | 67.3 (62.8, 71.5) | ||
| >=60 | 19.8 (18.3, 21.3) | 80.2 (78.7, 81.7) | 4.3 (2.9, 6.2) | 31.0 (28.6, 33.5) | 64.7 (62.4, 66.9) | ||
| Non-Hispanic Black | 12-19 | 6.4 (4.6, 8.9) | 93.6 (91.1, 95.4) | 0.4 (0.1, 1.8) | 12.1 (8.5, 16.9) | 87.5 (82.7, 91.2) | |
| 20-39 | 5.5 (4.3, 7.0) | 94.5 (93.0, 95.7) | 0.6 (0.2, 1.6) | 9.9 (7.6, 12.7) | 89.6 (86.8, 91.8) | ||
| 40-59 | 5.7 (4.2, 7.8) | 94.3 (92.2, 95.8) | 0.9 (0.3, 3.0) | 9.7 (7.2, 12.9) | 89.4 (86.1, 92.0) | ||
| >=60 | 4.1 (2.8, 5.9) | 95.9 (94.1, 97.2) | 0.6 (0.1, 3.0) | 6.9 (4.4, 10.5) | 92.5 (89.1, 94.9) | ||
| Mexican American | 12-19 | 15.8 (13.2, 18.7) | 84.2 (81.3, 86.8) | 3.5 (1.8, 6.7) | 24.7 (19.4, 30.8) | 71.9 (66.5, 76.7) | |
| 20-39 | 15.6 (12.9, 18.6) | 84.4 (81.4, 87.1) | 2.4 (1.4, 3.8) | 26.4 (21.3, 32.3) | 71.2 (65.4, 76.4) | ||
| 40-59 | 13.3 (11.6, 15.1) | 86.7 (84.9, 88.4) | 2.5 (1.0, 5.7) | 21.6 (19.4, 24.1) | 75.9 (73.7, 78.0) | ||
| >=60 | 13.6 (11.0, 16.6) | 86.4 (83.4, 89.0) | 1.0 (0.3, 3.5) | 25.1 (21.0, 29.6) | 73.9 (68.8, 78.4) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1800790 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 19.5 (17.8, 21.3) | 80.5 (78.7, 82.2) | 3.2 (2.4, 4.3) | 32.5 (29.7, 35.5) | 64.3 (61.2, 67.2) | |
| Female | 19.3 (17.5, 21.2) | 80.7 (78.8, 82.5) | 3.6 (2.3, 5.7) | 31.4 (29.4, 33.5) | 65.0 (62.5, 67.4) | ||
| Non-Hispanic Black | Male | 5.7 (4.7, 6.9) | 94.3 (93.1, 95.3) | 0.6 (0.2, 2.0) | 10.3 (8.4, 12.7) | 89.1 (86.9, 91.0) | |
| Female | 5.4 (4.0, 7.1) | 94.6 (92.9, 96.0) | 0.7 (0.3, 1.6) | 9.4 (6.9, 12.7) | 89.9 (86.6, 92.5) | ||
| Mexican American | Male | 15.5 (14.0, 17.1) | 84.5 (82.9, 86.0) | 2.7 (2.0, 3.8) | 25.5 (23.4, 27.7) | 71.7 (69.1, 74.2) | |
| Female | 14.4 (12.5, 16.4) | 85.6 (83.6, 87.5) | 2.2 (1.5, 3.4) | 24.3 (20.6, 28.4) | 73.5 (69.5, 77.1) | ||
- Page last reviewed: March 16, 2009 (archived document)
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