IL1B Allele and Genotype Frequencies
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Available polymorphism(s)
|
rs number |
Common Designations
Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs1143623 |
-2022G>C |
TaqMan |
|
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1143623 | C | G | CC | CG | GG | ||||
| Non-Hispanic White | 28.5 (26.0, 31.1) | 71.5 (68.9, 74.0) | <0.001 | 9.0 (7.2, 11.1) | 39.1 (36.8, 41.4) | 52.0 (48.5, 55.4) | <0.001 | 0.76 | |
| Non-Hispanic Black | 11.2 (10.0, 12.7) | 88.8 (87.3, 90.0) | 1.1 (0.6, 1.9) | 20.3 (18.4, 22.3) | 78.6 (76.3, 80.8) | 0.58 | |||
| Mexican American | 42.9 (40.5, 45.4) | 57.1 (54.6, 59.5) | 19.4 (16.9, 22.2) | 47.1 (44.1, 50.2) | 33.5 (30.4, 36.8) | 0.44 | |||
| Total* | 28.7 (26.5, 31.0) | 71.3 (69.0, 73.5) | 9.6 (7.9, 11.6) | 38.1 (36.4, 39.9) | 52.2 (49.4, 55.0) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1143623 | C | G | CC | CG | GG | |||
| 12-19 | 29.0 (23.4, 35.4) | 71.0 (64.6, 76.6) | 0.386 | 10.0 (6.0, 16.3) | 38.0 (31.3, 45.1) | 52.0 (43.6, 60.3) | 0.362 | |
| 20-39 | 28.9 (26.9, 31.0) | 71.1 (69.0, 73.1) | 9.8 (7.4, 12.9) | 38.3 (35.6, 41.1) | 51.9 (49.7, 54.0) | |||
| 40-59 | 29.9 (26.3, 33.8) | 70.1 (66.2, 73.7) | 11.0 (8.3, 14.3) | 37.9 (33.7, 42.3) | 51.1 (45.7, 56.5) | |||
| >=60 | 26.3 (23.5, 29.3) | 73.7 (70.7, 76.5) | 7.1 (5.3, 9.6) | 38.2 (34.3, 42.3) | 54.6 (50.1, 59.1) | |||
| Total | 28.7 (26.5, 31.0) | 71.3 (69.0, 73.5) | 9.6 (7.9, 11.6) | 38.1 (36.4, 39.9) | 52.2 (49.4, 55.0) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1143623 | C | G | CC | CG | GG | |||
| Male | 29.6 (26.8, 32.6) | 70.4 (67.4, 73.2) | 0.115 | 10.3 (8.3, 12.8) | 38.6 (35.5, 41.8) | 51.1 (47.0, 55.2) | 0.338 | |
| Female | 27.9 (25.8, 30.0) | 72.1 (70.0, 74.2) | 9.0 (7.0, 11.4) | 37.7 (35.3, 40.2) | 53.3 (50.7, 55.9) | |||
| Total | 28.7 (26.5, 31.0) | 71.3 (69.0, 73.5) | 9.6 (7.9, 11.6) | 38.1 (36.4, 39.9) | 52.2 (49.4, 55.0) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1143623 | C | G | CC | CG | GG | ||
| Non-Hispanic White | 12-19 | 30.0 (23.7, 37.2) | 70.0 (62.8, 76.3) | 9.4 (5.3, 16.1) | 41.2 (31.8, 51.2) | 49.4 (39.0, 59.9) | |
| 20-39 | 27.8 (25.5, 30.3) | 72.2 (69.7, 74.5) | 8.7 (6.2, 12.0) | 38.3 (35.3, 41.5) | 53.0 (50.2, 55.8) | ||
| 40-59 | 30.1 (25.9, 34.8) | 69.9 (65.2, 74.1) | 10.3 (7.5, 13.8) | 39.8 (34.0, 45.9) | 50.0 (43.1, 56.8) | ||
| >=60 | 26.6 (23.3, 30.1) | 73.4 (69.9, 76.7) | 7.5 (5.3, 10.4) | 38.2 (34.1, 42.5) | 54.3 (49.3, 59.3) | ||
| Non-Hispanic Black | 12-19 | 12.0 (9.5, 15.0) | 88.0 (85.0, 90.5) | 0.8 (0.4, 1.6) | 22.4 (17.5, 28.1) | 76.9 (71.1, 81.8) | |
| 20-39 | 12.2 (10.2, 14.6) | 87.8 (85.4, 89.8) | 1.4 (0.8, 2.6) | 21.7 (18.4, 25.4) | 76.9 (72.9, 80.5) | ||
| 40-59 | 9.6 (7.1, 12.9) | 90.4 (87.1, 92.9) | 1.1 (0.3, 3.8) | 17.0 (13.0, 22.0) | 81.9 (76.4, 86.3) | ||
| >=60 | 10.1 (7.5, 13.4) | 89.9 (86.6, 92.5) | 0.4 (0.1, 3.6) | 19.2 (13.6, 26.5) | 80.3 (73.5, 85.7) | ||
| Mexican American | 12-19 | 39.3 (36.5, 42.2) | 60.7 (57.8, 63.5) | 17.9 (14.8, 21.4) | 42.9 (36.4, 49.7) | 39.2 (34.1, 44.6) | |
| 20-39 | 44.9 (41.2, 48.6) | 55.1 (51.4, 58.8) | 20.9 (17.1, 25.3) | 47.9 (44.5, 51.3) | 31.2 (27.3, 35.3) | ||
| 40-59 | 42.9 (37.3, 48.8) | 57.1 (51.2, 62.7) | 19.1 (13.8, 25.7) | 47.7 (40.1, 55.5) | 33.2 (25.9, 41.4) | ||
| >=60 | 40.0 (37.1, 43.0) | 60.0 (57.0, 62.9) | 14.6 (10.9, 19.3) | 50.9 (44.6, 57.1) | 34.5 (30.2, 39.2) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1143623 | C | G | CC | CG | GG | ||
| Non-Hispanic White | Male | 28.9 (25.9, 32.0) | 71.1 (68.0, 74.1) | 9.3 (7.4, 11.7) | 39.1 (35.1, 43.2) | 51.6 (46.9, 56.3) | |
| Female | 28.1 (25.3, 31.2) | 71.9 (68.8, 74.7) | 8.6 (6.3, 11.7) | 39.0 (35.9, 42.3) | 52.3 (48.4, 56.2) | ||
| Non-Hispanic Black | Male | 11.3 (9.9, 12.8) | 88.7 (87.2, 90.1) | 1.2 (0.5, 2.9) | 20.1 (18.0, 22.4) | 78.7 (76.2, 80.9) | |
| Female | 11.2 (9.6, 13.1) | 88.8 (86.9, 90.4) | 1.0 (0.5, 1.9) | 20.5 (17.8, 23.4) | 78.6 (75.3, 81.5) | ||
| Mexican American | Male | 44.5 (40.9, 48.2) | 55.5 (51.8, 59.1) | 21.6 (17.9, 25.7) | 46.0 (40.8, 51.3) | 32.5 (27.7, 37.7) | |
| Female | 41.2 (39.1, 43.4) | 58.8 (56.6, 60.9) | 17.1 (14.6, 19.9) | 48.3 (44.7, 51.9) | 34.6 (31.8, 37.5) | ||
- Page last reviewed: March 16, 2009 (archived document)
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