ITGA2 Allele and Genotype Frequencies
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This website is archived for historical purposes and is no longer being maintained or updated.
Available polymorphism(s)
|
rs number |
Common Designations Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs1126643 |
Ex7-21C>T |
Phe253Phe |
TaqMan |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1126643 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 58.8 (56.7, 60.9) | 41.2 (39.1, 43.3) | <0.001 | 34.7 (32.8, 36.6) | 48.3 (46.3, 50.3) | 17.0 (14.5, 19.8) | <0.001 | 0.64 | |
| Non-Hispanic Black | 70.4 (68.0, 72.7) | 29.6 (27.3, 32.0) | 48.5 (45.3, 51.8) | 43.7 (41.3, 46.0) | 7.8 (6.1, 9.8) | 0.14 | |||
| Mexican American | 55.4 (53.8, 56.9) | 44.6 (43.1, 46.2) | 30.3 (28.3, 32.4) | 50.1 (47.9, 52.3) | 19.6 (17.9, 21.3) | 0.99 | |||
| Total* | 60.3 (58.8, 61.8) | 39.7 (38.2, 41.2) | 36.5 (35.1, 37.9) | 47.6 (46.2, 49.1) | 15.9 (14.1, 17.9) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1126643 | C | T | CC | CT | TT | |||
| 12-19 | 57.5 (53.1, 61.9) | 42.5 (38.1, 46.9) | 0.477 | 34.2 (29.9, 38.8) | 46.6 (42.2, 51.2) | 19.2 (14.3, 25.2) | 0.432 | |
| 20-39 | 60.9 (58.2, 63.4) | 39.1 (36.6, 41.8) | 36.5 (33.7, 39.4) | 48.7 (45.8, 51.7) | 14.8 (11.9, 18.2) | |||
| 40-59 | 60.5 (57.2, 63.7) | 39.5 (36.3, 42.8) | 37.5 (33.3, 41.9) | 45.9 (42.4, 49.4) | 16.6 (13.8, 19.8) | |||
| >=60 | 60.9 (58.9, 62.8) | 39.1 (37.2, 41.1) | 36.6 (34.3, 39.0) | 48.6 (46.3, 50.8) | 14.8 (12.8, 17.1) | |||
| Total | 60.3 (58.8, 61.8) | 39.7 (38.2, 41.2) | 36.5 (35.1, 37.9) | 47.6 (46.2, 49.1) | 15.9 (14.1, 17.9) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1126643 | C | T | CC | CT | TT | |||
| Male | 60.3 (58.0, 62.6) | 39.7 (37.4, 42.0) | 1.000 | 37.2 (34.5, 40.1) | 46.1 (44.0, 48.2) | 16.7 (14.5, 19.0) | 0.225 | |
| Female | 60.3 (58.4, 62.2) | 39.7 (37.8, 41.6) | 35.8 (33.6, 38.0) | 49.0 (46.3, 51.8) | 15.2 (12.9, 17.8) | |||
| Total | 60.3 (58.8, 61.8) | 39.7 (38.2, 41.2) | 36.5 (35.1, 37.9) | 47.6 (46.2, 49.1) | 15.9 (14.1, 17.9) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1126643 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 54.1 (48.3, 59.8) | 45.9 (40.2, 51.7) | 30.4 (24.5, 37.0) | 47.5 (40.9, 54.1) | 22.1 (15.9, 30.0) | |
| 20-39 | 59.5 (56.4, 62.5) | 40.5 (37.5, 43.6) | 34.2 (30.8, 37.7) | 50.6 (46.5, 54.6) | 15.2 (11.8, 19.5) | ||
| 40-59 | 58.8 (54.6, 63.0) | 41.2 (37.0, 45.4) | 36.3 (31.0, 42.0) | 45.1 (40.5, 49.7) | 18.6 (15.0, 22.8) | ||
| >=60 | 60.3 (58.3, 62.4) | 39.7 (37.6, 41.7) | 35.6 (33.0, 38.3) | 49.4 (46.6, 52.2) | 15.0 (12.8, 17.4) | ||
| Non-Hispanic Black | 12-19 | 70.6 (66.0, 74.9) | 29.4 (25.1, 34.0) | 49.8 (42.2, 57.4) | 41.6 (34.8, 48.8) | 8.6 (6.5, 11.2) | |
| 20-39 | 69.3 (65.7, 72.7) | 30.7 (27.3, 34.3) | 47.9 (43.6, 52.3) | 42.7 (38.8, 46.7) | 9.4 (6.3, 13.7) | ||
| 40-59 | 70.7 (68.4, 72.9) | 29.3 (27.1, 31.6) | 47.0 (43.1, 50.8) | 47.5 (43.6, 51.4) | 5.5 (4.0, 7.6) | ||
| >=60 | 72.8 (68.0, 77.2) | 27.2 (22.8, 32.0) | 51.6 (44.5, 58.6) | 42.5 (36.4, 48.9) | 5.9 (3.3, 10.4) | ||
| Mexican American | 12-19 | 53.1 (49.3, 56.9) | 46.9 (43.1, 50.7) | 26.9 (21.7, 32.9) | 52.4 (46.1, 58.6) | 20.6 (16.8, 25.2) | |
| 20-39 | 55.7 (53.5, 57.9) | 44.3 (42.1, 46.5) | 31.5 (29.1, 34.0) | 48.4 (45.7, 51.1) | 20.1 (17.6, 22.9) | ||
| 40-59 | 57.0 (53.6, 60.3) | 43.0 (39.7, 46.4) | 30.8 (27.5, 34.3) | 52.3 (47.4, 57.2) | 16.9 (12.6, 22.3) | ||
| >=60 | 54.9 (50.9, 58.8) | 45.1 (41.2, 49.1) | 30.3 (26.1, 34.8) | 49.2 (44.2, 54.2) | 20.5 (15.9, 26.0) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1126643 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 59.1 (56.4, 61.7) | 40.9 (38.3, 43.6) | 35.4 (32.2, 38.7) | 47.4 (44.5, 50.3) | 17.2 (14.6, 20.2) | |
| Female | 58.6 (56.0, 61.2) | 41.4 (38.8, 44.0) | 34.0 (31.6, 36.5) | 49.2 (46.1, 52.4) | 16.8 (13.6, 20.6) | ||
| Non-Hispanic Black | Male | 69.6 (66.2, 72.8) | 30.4 (27.2, 33.8) | 46.2 (41.3, 51.2) | 46.7 (42.5, 51.0) | 7.1 (4.9, 10.0) | |
| Female | 71.0 (68.6, 73.3) | 29.0 (26.7, 31.4) | 50.4 (47.2, 53.7) | 41.2 (39.1, 43.3) | 8.4 (6.8, 10.3) | ||
| Mexican American | Male | 55.2 (52.6, 57.8) | 44.8 (42.2, 47.4) | 31.3 (28.2, 34.6) | 47.8 (43.7, 51.9) | 20.9 (17.7, 24.5) | |
| Female | 55.6 (53.9, 57.2) | 44.4 (42.8, 46.1) | 29.3 (27.0, 31.6) | 52.6 (50.1, 55.1) | 18.2 (16.3, 20.1) | ||
- Page last reviewed: March 16, 2009 (archived document)
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