NQO1 Allele and Genotype Frequencies
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Available polymorphism(s)
|
rs number |
Common Designations Nucleotide change Amino acid |
Genotyping method |
|
|---|---|---|---|
|
rs10517 |
Ex6-457C>T |
TaqMan |
|
|
rs1800566 |
Ex6+40C>T |
Pro187Ser |
TaqMan |
|
rs34755915 |
IVS3+20G>A |
TaqMan |
|
|
rs689452 |
IVS1-27C>G |
TaqMan |
|
|
rs689453 |
Ex2+65G>A |
Glu24Glu |
TaqMan |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs10517 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 86.8 (85.7, 87.9) | 13.2 (12.1, 14.3) | <0.001 | 75.5 (73.5, 77.3) | 22.8 (21.0, 24.7) | 1.8 (1.2, 2.6) | 0.001 | 0.65 | |
| Non-Hispanic Black | 86.1 (84.6, 87.5) | 13.9 (12.5, 15.4) | 73.9 (71.4, 76.3) | 24.3 (22.2, 26.6) | 1.7 (1.1, 2.7) | 0.65 | |||
| Mexican American | 93.5 (91.7, 94.9) | 6.5 (5.1, 8.3) | 87.2 (83.8, 90.0) | 12.6 (9.8, 16.0) | 0.2 (0.1, 0.5) | 0.20 | |||
| Total* | 86.4 (85.1, 87.7) | 13.6 (12.3, 14.9) | 75.0 (73.0, 77.0) | 22.9 (21.4, 24.4) | 2.1 (1.5, 3.0) | ||||
| rs1800566 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 80.6 (78.7, 82.4) | 19.4 (17.6, 21.3) | <0.001 | 64.7 (61.2, 68.0) | 31.8 (28.7, 35.1) | 3.5 (2.8, 4.3) | <0.001 | 0.51 | |
| Non-Hispanic Black | 81.2 (80.0, 82.3) | 18.8 (17.7, 20.0) | 65.8 (64.1, 67.5) | 30.7 (29.1, 32.3) | 3.5 (2.7, 4.6) | 0.93 | |||
| Mexican American | 63.2 (61.2, 65.1) | 36.8 (34.9, 38.8) | 40.4 (37.5, 43.4) | 45.6 (42.8, 48.4) | 14.0 (12.4, 15.8) | 0.93 | |||
| Total* | 78.5 (76.8, 80.2) | 21.5 (19.8, 23.2) | 61.8 (58.8, 64.7) | 33.4 (30.8, 36.2) | 4.8 (4.1, 5.6) | ||||
| rs34755915 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 1.8 (1.5, 2.3) | 98.2 (97.7, 98.5) | <0.001 | 0.0 (0.0, 0.4) | 3.5 (2.9, 4.4) | 96.4 (95.6, 97.1) | <0.001 | 0.81 | |
| Non-Hispanic Black | 0.4 (0.2, 0.8) | 99.6 (99.2, 99.8) | 0.0 (NA) | 0.8 (0.4, 1.6) | 99.2 (98.4, 99.6) | 0.88 | |||
| Mexican American | 0.5 (0.3, 0.9) | 99.5 (99.1, 99.7) | 0.0 (NA) | 1.1 (0.6, 1.8) | 98.9 (98.2, 99.4) | 0.82 | |||
| Total* | 1.4 (1.1, 1.8) | 98.6 (98.2, 98.9) | 0.0 (0.0, 0.3) | 2.8 (2.2, 3.5) | 97.2 (96.5, 97.8) | ||||
| rs689452 | C | G | CC | CG | GG | ||||
| Non-Hispanic White | 88.1 (87.1, 89.0) | 11.9 (11.0, 12.9) | <0.001 | 77.5 (75.7, 79.3) | 21.1 (19.4, 23.0) | 1.3 (0.9, 2.0) | <0.001 | 0.23 | |
| Non-Hispanic Black | 86.3 (84.7, 87.7) | 13.7 (12.3, 15.3) | 74.2 (71.7, 76.6) | 24.1 (21.9, 26.4) | 1.7 (1.1, 2.6) | 0.63 | |||
| Mexican American | 93.7 (91.8, 95.1) | 6.3 (4.9, 8.2) | 87.5 (83.9, 90.4) | 12.3 (9.4, 15.8) | 0.2 (0.1, 0.5) | 0.25 | |||
| Total* | 87.5 (86.3, 88.6) | 12.5 (11.4, 13.7) | 76.6 (74.8, 78.4) | 21.6 (20.2, 23.2) | 1.7 (1.2, 2.5) | ||||
| rs689453 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 7.9 (6.7, 9.2) | 92.1 (90.8, 93.3) | <0.001 | 0.5 (0.2, 1.1) | 14.7 (12.7, 17.0) | 84.8 (82.4, 86.9) | 0.005 | 0.23 | |
| Non-Hispanic Black | 5.1 (4.2, 6.2) | 94.9 (93.8, 95.8) | 0.4 (0.1, 1.1) | 9.5 (7.5, 11.9) | 90.2 (87.9, 92.1) | 0.25 | |||
| Mexican American | 5.2 (3.8, 7.0) | 94.8 (93.0, 96.2) | 0.6 (0.3, 1.3) | 9.2 (7.1, 12.0) | 90.2 (87.0, 92.6) | 0.21 | |||
| Total* | 7.0 (6.1, 8.1) | 93.0 (91.9, 93.9) | 0.4 (0.2, 0.9) | 13.2 (11.4, 15.1) | 86.4 (84.4, 88.2) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs10517 | C | T | CC | CT | TT | |||
| 12-19 | 85.7 (83.4, 87.8) | 14.3 (12.2, 16.6) | 0.894 | 74.3 (70.3, 77.8) | 22.9 (19.2, 27.1) | 2.8 (1.4, 5.4) | 0.864 | |
| 20-39 | 86.7 (84.3, 88.7) | 13.3 (11.3, 15.7) | 75.2 (71.4, 78.7) | 22.9 (20.0, 26.1) | 1.9 (1.2, 3.0) | |||
| 40-59 | 86.3 (84.4, 88.1) | 13.7 (11.9, 15.6) | 74.7 (71.4, 77.8) | 23.2 (20.2, 26.6) | 2.0 (1.2, 3.6) | |||
| >=60 | 86.6 (84.7, 88.3) | 13.4 (11.7, 15.3) | 75.5 (72.4, 78.4) | 22.2 (19.5, 25.2) | 2.3 (1.2, 4.1) | |||
| Total | 86.4 (85.1, 87.7) | 13.6 (12.3, 14.9) | 75.0 (73.0, 77.0) | 22.9 (21.4, 24.4) | 2.1 (1.5, 3.0) | |||
| rs1800566 | C | T | CC | CT | TT | |||
| 12-19 | 76.1 (72.2, 79.5) | 23.9 (20.5, 27.8) | 0.108 | 57.5 (50.9, 63.9) | 37.1 (31.0, 43.6) | 5.4 (3.8, 7.6) | 0.185 | |
| 20-39 | 77.9 (75.5, 80.1) | 22.1 (19.9, 24.5) | 61.1 (57.2, 65.0) | 33.5 (30.1, 37.1) | 5.4 (4.3, 6.7) | |||
| 40-59 | 80.1 (77.3, 82.6) | 19.9 (17.4, 22.7) | 64.2 (59.3, 68.7) | 31.9 (27.5, 36.6) | 4.0 (2.8, 5.6) | |||
| >=60 | 79.3 (77.1, 81.4) | 20.7 (18.6, 22.9) | 62.9 (59.2, 66.5) | 32.9 (29.5, 36.4) | 4.2 (3.2, 5.6) | |||
| Total | 78.5 (76.8, 80.2) | 21.5 (19.8, 23.2) | 61.8 (58.8, 64.7) | 33.4 (30.8, 36.2) | 4.8 (4.1, 5.6) | |||
| rs34755915 | A | G | AA | AG | GG | |||
| 12-19 | 1.4 (0.7, 2.8) | 98.6 (97.2, 99.3) | 0.969 | 0.0 (NA) | 2.7 (1.3, 5.6) | 97.3 (94.4, 98.7) | 0.976 | |
| 20-39 | 1.4 (0.9, 2.2) | 98.6 (97.8, 99.1) | 0.0 (NA) | 2.8 (1.8, 4.4) | 97.2 (95.6, 98.2) | |||
| 40-59 | 1.4 (0.9, 2.1) | 98.6 (97.9, 99.1) | 0.0 (NA) | 2.8 (1.8, 4.2) | 97.2 (95.8, 98.2) | |||
| >=60 | 1.5 (1.0, 2.4) | 98.5 (97.6, 99.0) | 0.2 (0.0, 1.5) | 2.7 (1.9, 3.9) | 97.1 (95.7, 98.0) | |||
| Total | 1.4 (1.1, 1.8) | 98.6 (98.2, 98.9) | 0.0 (0.0, 0.3) | 2.8 (2.2, 3.5) | 97.2 (96.5, 97.8) | |||
| rs689452 | C | G | CC | CG | GG | |||
| 12-19 | 86.9 (84.9, 88.7) | 13.1 (11.3, 15.1) | 0.923 | 76.2 (72.8, 79.3) | 21.3 (17.9, 25.2) | 2.5 (1.2, 5.1) | 0.867 | |
| 20-39 | 87.6 (85.5, 89.5) | 12.4 (10.5, 14.5) | 76.6 (73.2, 79.7) | 22.0 (19.4, 24.7) | 1.4 (0.8, 2.5) | |||
| 40-59 | 87.4 (85.7, 89.0) | 12.6 (11.0, 14.3) | 76.6 (73.4, 79.5) | 21.7 (18.8, 25.0) | 1.7 (0.9, 3.2) | |||
| >=60 | 87.6 (85.7, 89.3) | 12.4 (10.7, 14.3) | 77.1 (73.8, 80.1) | 21.1 (18.3, 24.3) | 1.8 (1.0, 3.2) | |||
| Total | 87.5 (86.3, 88.6) | 12.5 (11.4, 13.7) | 76.6 (74.8, 78.4) | 21.6 (20.2, 23.2) | 1.7 (1.2, 2.5) | |||
| rs689453 | A | G | AA | AG | GG | |||
| 12-19 | 7.4 (5.2, 10.3) | 92.6 (89.7, 94.8) | 0.205 | 0.8 (0.2, 2.5) | 13.2 (9.2, 18.6) | 86.0 (80.6, 90.1) | 0.090 | |
| 20-39 | 6.2 (5.2, 7.5) | 93.8 (92.5, 94.8) | 0.3 (0.1, 1.0) | 11.8 (9.7, 14.3) | 87.9 (85.4, 89.9) | |||
| 40-59 | 7.6 (6.5, 9.0) | 92.4 (91.0, 93.5) | 0.3 (0.1, 1.0) | 14.7 (12.6, 17.1) | 85.0 (82.5, 87.2) | |||
| >=60 | 7.5 (6.2, 9.0) | 92.5 (91.0, 93.8) | 0.7 (0.3, 1.4) | 13.6 (11.1, 16.6) | 85.7 (82.8, 88.2) | |||
| Total | 7.0 (6.1, 8.1) | 93.0 (91.9, 93.9) | 0.4 (0.2, 0.9) | 13.2 (11.4, 15.1) | 86.4 (84.4, 88.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs10517 | C | T | CC | CT | TT | |||
| Male | 86.1 (84.2, 87.7) | 13.9 (12.3, 15.8) | 0.500 | 74.1 (71.2, 76.9) | 23.8 (21.3, 26.5) | 2.0 (1.1, 3.6) | 0.696 | |
| Female | 86.8 (85.0, 88.4) | 13.2 (11.6, 15.0) | 75.8 (72.6, 78.8) | 22.0 (19.2, 25.0) | 2.2 (1.7, 2.9) | |||
| Total | 86.4 (85.1, 87.7) | 13.6 (12.3, 14.9) | 75.0 (73.0, 77.0) | 22.9 (21.4, 24.4) | 2.1 (1.5, 3.0) | |||
| rs1800566 | C | T | CC | CT | TT | |||
| Male | 78.7 (76.2, 81.0) | 21.3 (19.0, 23.8) | 0.770 | 61.8 (57.5, 65.9) | 33.8 (29.8, 38.1) | 4.4 (3.2, 6.0) | 0.694 | |
| Female | 78.4 (76.7, 79.9) | 21.6 (20.1, 23.3) | 61.9 (59.0, 64.7) | 33.0 (30.3, 35.9) | 5.1 (4.3, 6.0) | |||
| Total | 78.5 (76.8, 80.2) | 21.5 (19.8, 23.2) | 61.8 (58.8, 64.7) | 33.4 (30.8, 36.2) | 4.8 (4.1, 5.6) | |||
| rs34755915 | A | G | AA | AG | GG | |||
| Male | 1.6 (1.2, 2.1) | 98.4 (97.9, 98.8) | 0.320 | 0.0 (NA) | 3.1 (2.4, 4.2) | 96.9 (95.8, 97.6) | 0.206 | |
| Female | 1.3 (0.9, 1.8) | 98.7 (98.2, 99.1) | 0.1 (0.0, 0.5) | 2.4 (1.8, 3.3) | 97.5 (96.5, 98.2) | |||
| Total | 1.4 (1.1, 1.8) | 98.6 (98.2, 98.9) | 0.0 (0.0, 0.3) | 2.8 (2.2, 3.5) | 97.2 (96.5, 97.8) | |||
| rs689452 | C | G | CC | CG | GG | |||
| Male | 87.2 (85.5, 88.7) | 12.8 (11.3, 14.5) | 0.545 | 76.0 (73.4, 78.5) | 22.3 (20.1, 24.6) | 1.7 (0.9, 3.1) | 0.815 | |
| Female | 87.8 (86.2, 89.2) | 12.2 (10.8, 13.8) | 77.2 (74.4, 79.9) | 21.1 (18.5, 23.9) | 1.7 (1.2, 2.5) | |||
| Total | 87.5 (86.3, 88.6) | 12.5 (11.4, 13.7) | 76.6 (74.8, 78.4) | 21.6 (20.2, 23.2) | 1.7 (1.2, 2.5) | |||
| rs689453 | A | G | AA | AG | GG | |||
| Male | 7.6 (6.2, 9.3) | 92.4 (90.7, 93.8) | 0.086 | 0.6 (0.3, 1.5) | 13.9 (11.4, 16.9) | 85.4 (82.3, 88.1) | 0.252 | |
| Female | 6.5 (5.7, 7.3) | 93.5 (92.7, 94.3) | 0.3 (0.1, 0.6) | 12.4 (10.9, 14.1) | 87.3 (85.6, 88.9) | |||
| Total | 7.0 (6.1, 8.1) | 93.0 (91.9, 93.9) | 0.4 (0.2, 0.9) | 13.2 (11.4, 15.1) | 86.4 (84.4, 88.2) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs10517 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 85.9 (82.3, 88.9) | 14.1 (11.1, 17.7) | 74.5 (68.6, 79.5) | 23.0 (18.6, 28.1) | 2.6 (1.3, 5.0) | |
| 20-39 | 86.7 (84.1, 89.0) | 13.3 (11.0, 15.9) | 74.8 (70.0, 79.1) | 23.8 (19.7, 28.5) | 1.4 (0.9, 2.1) | ||
| 40-59 | 87.0 (84.4, 89.2) | 13.0 (10.8, 15.6) | 76.0 (72.1, 79.6) | 22.0 (18.9, 25.4) | 2.0 (0.9, 4.4) | ||
| >=60 | 87.3 (85.7, 88.8) | 12.7 (11.2, 14.3) | 76.4 (73.4, 79.1) | 22.0 (19.2, 24.9) | 1.7 (0.9, 3.1) | ||
| Non-Hispanic Black | 12-19 | 85.9 (82.8, 88.5) | 14.1 (11.5, 17.2) | 73.9 (68.6, 78.5) | 24.0 (19.3, 29.4) | 2.1 (0.8, 5.6) | |
| 20-39 | 86.2 (84.1, 88.1) | 13.8 (11.9, 15.9) | 74.1 (70.4, 77.5) | 24.2 (20.8, 28.0) | 1.7 (0.8, 3.6) | ||
| 40-59 | 86.5 (84.2, 88.5) | 13.5 (11.5, 15.8) | 73.9 (69.7, 77.7) | 25.3 (21.7, 29.3) | 0.8 (0.3, 2.1) | ||
| >=60 | 85.4 (81.5, 88.7) | 14.6 (11.3, 18.5) | 73.7 (66.5, 79.7) | 23.6 (17.6, 30.8) | 2.8 (1.4, 5.2) | ||
| Mexican American | 12-19 | 94.5 (90.5, 96.8) | 5.5 (3.2, 9.5) | 89.5 (82.3, 94.0) | 9.9 (5.6, 16.8) | 0.6 (0.1, 2.6) | |
| 20-39 | 93.8 (92.3, 95.1) | 6.2 (4.9, 7.7) | 87.7 (84.7, 90.1) | 12.3 (9.9, 15.3) | 0.0 (NA) | ||
| 40-59 | 92.2 (89.6, 94.2) | 7.8 (5.8, 10.4) | 84.5 (79.4, 88.4) | 15.4 (11.4, 20.5) | 0.1 (0.0, 1.0) | ||
| >=60 | 92.5 (90.1, 94.4) | 7.5 (5.6, 9.9) | 85.9 (82.0, 89.1) | 13.2 (10.3, 16.8) | 0.8 (0.2, 3.4) | ||
| rs1800566 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 78.1 (73.4, 82.1) | 21.9 (17.9, 26.6) | 60.2 (52.4, 67.5) | 35.7 (28.9, 43.2) | 4.1 (2.1, 7.6) | |
| 20-39 | 80.9 (78.1, 83.3) | 19.1 (16.7, 21.9) | 64.6 (59.6, 69.3) | 32.5 (28.1, 37.2) | 2.9 (2.2, 3.9) | ||
| 40-59 | 81.4 (78.0, 84.4) | 18.6 (15.6, 22.0) | 66.8 (60.8, 72.3) | 29.1 (23.8, 35.0) | 4.1 (2.7, 6.1) | ||
| >=60 | 80.6 (78.0, 83.0) | 19.4 (17.0, 22.0) | 64.5 (60.0, 68.7) | 32.2 (28.5, 36.2) | 3.3 (2.4, 4.6) | ||
| Non-Hispanic Black | 12-19 | 82.5 (80.2, 84.5) | 17.5 (15.5, 19.8) | 67.8 (63.6, 71.8) | 29.2 (24.6, 34.3) | 2.9 (1.5, 5.6) | |
| 20-39 | 79.4 (77.6, 81.2) | 20.6 (18.8, 22.4) | 63.1 (59.7, 66.3) | 32.7 (29.2, 36.4) | 4.2 (3.0, 6.0) | ||
| 40-59 | 82.8 (79.5, 85.7) | 17.2 (14.3, 20.5) | 68.1 (62.2, 73.4) | 29.5 (24.4, 35.1) | 2.5 (1.4, 4.4) | ||
| >=60 | 81.9 (78.6, 84.7) | 18.1 (15.3, 21.4) | 67.6 (62.6, 72.3) | 28.5 (24.1, 33.3) | 3.9 (2.1, 7.0) | ||
| Mexican American | 12-19 | 60.6 (56.1, 64.9) | 39.4 (35.1, 43.9) | 39.4 (32.9, 46.3) | 42.3 (35.5, 49.4) | 18.3 (14.4, 22.9) | |
| 20-39 | 64.5 (62.3, 66.7) | 35.5 (33.3, 37.7) | 42.4 (39.3, 45.6) | 44.3 (41.5, 47.2) | 13.3 (11.5, 15.3) | ||
| 40-59 | 61.9 (58.8, 64.8) | 38.1 (35.2, 41.2) | 36.2 (31.6, 41.1) | 51.4 (45.4, 57.2) | 12.4 (9.3, 16.5) | ||
| >=60 | 64.7 (60.8, 68.4) | 35.3 (31.6, 39.2) | 41.5 (35.7, 47.6) | 46.4 (40.5, 52.4) | 12.1 (9.2, 15.9) | ||
| rs34755915 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 2.0 (0.9, 4.2) | 98.0 (95.8, 99.1) | 0.0 (NA) | 4.0 (1.9, 8.4) | 96.0 (91.6, 98.1) | |
| 20-39 | 1.8 (1.2, 2.8) | 98.2 (97.2, 98.8) | 0.0 (NA) | 3.7 (2.4, 5.6) | 96.3 (94.4, 97.6) | ||
| 40-59 | 1.7 (1.1, 2.6) | 98.3 (97.4, 98.9) | 0.0 (NA) | 3.4 (2.2, 5.3) | 96.6 (94.7, 97.8) | ||
| >=60 | 1.8 (1.2, 2.8) | 98.2 (97.2, 98.8) | 0.2 (0.0, 1.8) | 3.2 (2.3, 4.5) | 96.6 (95.0, 97.7) | ||
| Non-Hispanic Black | 12-19 | 0.1 (0.0, 0.7) | 99.9 (99.3, 100.0) | 0.0 (NA) | 0.2 (0.0, 1.4) | 99.8 (98.6, 100.0) | |
| 20-39 | 0.6 (0.2, 1.7) | 99.4 (98.3, 99.8) | 0.0 (NA) | 1.2 (0.4, 3.3) | 98.8 (96.7, 99.6) | ||
| 40-59 | 0.3 (0.1, 1.0) | 99.7 (99.0, 99.9) | 0.0 (NA) | 0.7 (0.2, 2.0) | 99.3 (98.0, 99.8) | ||
| >=60 | 0.3 (0.1, 1.4) | 99.7 (98.6, 99.9) | 0.0 (NA) | 0.6 (0.2, 2.7) | 99.4 (97.3, 99.8) | ||
| Mexican American | 12-19 | 0.5 (0.1, 2.2) | 99.5 (97.8, 99.9) | 0.0 (NA) | 1.0 (0.2, 4.3) | 99.0 (95.7, 99.8) | |
| 20-39 | 0.6 (0.3, 1.2) | 99.4 (98.8, 99.7) | 0.0 (NA) | 1.2 (0.6, 2.3) | 98.8 (97.7, 99.4) | ||
| 40-59 | 0.5 (0.2, 1.6) | 99.5 (98.4, 99.8) | 0.0 (NA) | 1.0 (0.3, 3.2) | 99.0 (96.8, 99.7) | ||
| >=60 | 0.5 (0.2, 1.3) | 99.5 (98.7, 99.8) | 0.0 (NA) | 0.9 (0.3, 2.7) | 99.1 (97.3, 99.7) | ||
| rs689452 | C | G | CC | CG | GG | ||
| Non-Hispanic White | 12-19 | 87.3 (84.0, 90.0) | 12.7 (10.0, 16.0) | 76.6 (71.3, 81.2) | 21.3 (17.2, 26.1) | 2.0 (0.9, 4.5) | |
| 20-39 | 88.0 (85.5, 90.1) | 12.0 (9.9, 14.5) | 77.0 (72.4, 80.9) | 22.1 (18.3, 26.3) | 1.0 (0.5, 1.8) | ||
| 40-59 | 88.3 (86.0, 90.2) | 11.7 (9.8, 14.0) | 78.1 (74.5, 81.4) | 20.3 (17.3, 23.7) | 1.6 (0.6, 4.1) | ||
| >=60 | 88.5 (86.8, 90.0) | 11.5 (10.0, 13.2) | 78.2 (75.0, 81.1) | 20.5 (17.7, 23.7) | 1.2 (0.7, 2.3) | ||
| Non-Hispanic Black | 12-19 | 85.7 (82.6, 88.3) | 14.3 (11.7, 17.4) | 73.6 (68.3, 78.2) | 24.3 (19.6, 29.7) | 2.1 (0.8, 5.7) | |
| 20-39 | 86.3 (84.4, 87.9) | 13.7 (12.1, 15.6) | 74.2 (70.8, 77.3) | 24.2 (20.9, 27.8) | 1.6 (0.8, 3.5) | ||
| 40-59 | 86.9 (84.5, 89.0) | 13.1 (11.0, 15.5) | 74.7 (70.3, 78.6) | 24.5 (20.7, 28.6) | 0.8 (0.3, 2.1) | ||
| >=60 | 85.8 (81.8, 89.1) | 14.2 (10.9, 18.2) | 74.4 (67.0, 80.5) | 22.9 (16.9, 30.2) | 2.8 (1.4, 5.2) | ||
| Mexican American | 12-19 | 94.6 (90.8, 96.9) | 5.4 (3.1, 9.2) | 89.9 (82.9, 94.2) | 9.5 (5.4, 16.1) | 0.6 (0.1, 2.6) | |
| 20-39 | 93.9 (92.2, 95.3) | 6.1 (4.7, 7.8) | 87.8 (84.4, 90.6) | 12.2 (9.4, 15.6) | 0.0 (NA) | ||
| 40-59 | 92.4 (89.9, 94.4) | 7.6 (5.6, 10.1) | 85.0 (80.1, 88.9) | 14.9 (11.0, 19.8) | 0.1 (0.0, 1.0) | ||
| >=60 | 92.8 (90.0, 94.8) | 7.2 (5.2, 10.0) | 86.4 (81.7, 90.1) | 12.7 (9.3, 17.1) | 0.8 (0.2, 3.4) | ||
| rs689453 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 8.6 (5.5, 13.0) | 91.4 (87.0, 94.5) | 1.1 (0.3, 3.8) | 14.9 (9.3, 23.0) | 84.0 (75.8, 89.8) | |
| 20-39 | 6.9 (5.6, 8.5) | 93.1 (91.5, 94.4) | 0.4 (0.1, 1.3) | 13.1 (10.5, 16.2) | 86.5 (83.5, 89.1) | ||
| 40-59 | 8.5 (7.0, 10.4) | 91.5 (89.6, 93.0) | 0.3 (0.1, 1.5) | 16.5 (13.8, 19.8) | 83.2 (79.8, 86.1) | ||
| >=60 | 8.2 (6.7, 10.0) | 91.8 (90.0, 93.3) | 0.7 (0.3, 1.6) | 15.0 (12.0, 18.5) | 84.3 (80.9, 87.2) | ||
| Non-Hispanic Black | 12-19 | 5.5 (4.1, 7.3) | 94.5 (92.7, 95.9) | 0.3 (0.1, 1.1) | 10.4 (7.6, 14.0) | 89.3 (85.8, 92.1) | |
| 20-39 | 4.3 (3.3, 5.5) | 95.7 (94.5, 96.7) | 0.2 (0.0, 0.7) | 8.2 (6.3, 10.8) | 91.6 (89.1, 93.6) | ||
| 40-59 | 5.3 (3.8, 7.5) | 94.7 (92.5, 96.2) | 0.5 (0.1, 3.6) | 9.7 (6.6, 14.1) | 89.8 (85.7, 92.9) | ||
| >=60 | 6.6 (4.7, 9.2) | 93.4 (90.8, 95.3) | 0.8 (0.2, 3.4) | 11.5 (7.5, 17.1) | 87.7 (82.5, 91.5) | ||
| Mexican American | 12-19 | 5.0 (2.7, 9.1) | 95.0 (90.9, 97.3) | 0.0 (NA) | 10.1 (5.4, 18.0) | 89.9 (82.0, 94.6) | |
| 20-39 | 5.5 (4.0, 7.5) | 94.5 (92.5, 96.0) | 0.7 (0.3, 1.8) | 9.5 (7.1, 12.6) | 89.8 (86.3, 92.5) | ||
| 40-59 | 5.6 (4.0, 7.8) | 94.4 (92.2, 96.0) | 0.8 (0.2, 3.1) | 9.5 (6.6, 13.6) | 89.7 (85.7, 92.6) | ||
| >=60 | 3.1 (2.5, 3.9) | 96.9 (96.1, 97.5) | 0.6 (0.1, 3.8) | 5.0 (3.2, 7.8) | 94.4 (92.7, 95.7) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs10517 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 86.6 (84.8, 88.1) | 13.4 (11.9, 15.2) | 74.5 (71.0, 77.8) | 24.1 (20.6, 28.0) | 1.4 (0.8, 2.5) | |
| Female | 87.1 (85.1, 88.8) | 12.9 (11.2, 14.9) | 76.3 (73.0, 79.4) | 21.5 (18.8, 24.5) | 2.1 (1.4, 3.2) | ||
| Non-Hispanic Black | Male | 85.2 (82.9, 87.2) | 14.8 (12.8, 17.1) | 72.0 (67.9, 75.8) | 26.3 (22.7, 30.3) | 1.7 (0.9, 3.2) | |
| Female | 86.9 (84.5, 89.0) | 13.1 (11.0, 15.5) | 75.5 (71.6, 79.1) | 22.7 (19.5, 26.3) | 1.7 (0.8, 3.7) | ||
| Mexican American | Male | 93.8 (91.2, 95.7) | 6.2 (4.3, 8.8) | 87.7 (82.6, 91.5) | 12.2 (8.4, 17.3) | 0.1 (0.0, 0.7) | |
| Female | 93.2 (91.5, 94.5) | 6.8 (5.5, 8.5) | 86.7 (83.5, 89.3) | 13.0 (10.4, 16.1) | 0.3 (0.1, 0.8) | ||
| rs1800566 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 81.2 (78.7, 83.4) | 18.8 (16.6, 21.3) | 65.1 (60.3, 69.6) | 32.2 (27.6, 37.3) | 2.7 (1.8, 4.2) | |
| Female | 80.1 (78.0, 82.0) | 19.9 (18.0, 22.0) | 64.3 (60.8, 67.7) | 31.5 (28.2, 35.0) | 4.2 (3.1, 5.7) | ||
| Non-Hispanic Black | Male | 80.6 (78.0, 82.9) | 19.4 (17.1, 22.0) | 65.2 (61.6, 68.5) | 30.9 (28.0, 33.9) | 4.0 (2.3, 6.8) | |
| Female | 81.6 (80.4, 82.8) | 18.4 (17.2, 19.6) | 66.4 (64.3, 68.5) | 30.5 (28.5, 32.6) | 3.1 (2.5, 3.9) | ||
| Mexican American | Male | 62.1 (59.6, 64.6) | 37.9 (35.4, 40.4) | 38.8 (35.6, 42.1) | 46.7 (43.7, 49.7) | 14.5 (12.1, 17.3) | |
| Female | 64.3 (61.8, 66.7) | 35.7 (33.3, 38.2) | 42.1 (38.2, 46.0) | 44.4 (40.8, 48.2) | 13.5 (11.7, 15.5) | ||
| rs34755915 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 2.0 (1.5, 2.6) | 98.0 (97.4, 98.5) | 0.0 (NA) | 4.0 (3.0, 5.3) | 96.0 (94.7, 97.0) | |
| Female | 1.7 (1.2, 2.3) | 98.3 (97.7, 98.8) | 0.1 (0.0, 0.7) | 3.1 (2.3, 4.2) | 96.8 (95.6, 97.6) | ||
| Non-Hispanic Black | Male | 0.5 (0.2, 1.3) | 99.5 (98.7, 99.8) | 0.0 (NA) | 0.9 (0.4, 2.5) | 99.1 (97.5, 99.6) | |
| Female | 0.3 (0.2, 0.7) | 99.7 (99.3, 99.8) | 0.0 (NA) | 0.7 (0.3, 1.4) | 99.3 (98.6, 99.7) | ||
| Mexican American | Male | 0.6 (0.3, 1.3) | 99.4 (98.7, 99.7) | 0.0 (NA) | 1.3 (0.6, 2.5) | 98.7 (97.5, 99.4) | |
| Female | 0.4 (0.3, 0.7) | 99.6 (99.3, 99.7) | 0.0 (NA) | 0.9 (0.5, 1.4) | 99.1 (98.6, 99.5) | ||
| rs689452 | C | G | CC | CG | GG | ||
| Non-Hispanic White | Male | 87.9 (86.1, 89.4) | 12.1 (10.6, 13.9) | 76.9 (73.4, 80.0) | 22.0 (18.8, 25.5) | 1.2 (0.7, 2.0) | |
| Female | 88.3 (86.6, 89.8) | 11.7 (10.2, 13.4) | 78.2 (75.2, 80.9) | 20.3 (17.8, 23.1) | 1.5 (0.9, 2.6) | ||
| Non-Hispanic Black | Male | 85.1 (82.7, 87.3) | 14.9 (12.7, 17.3) | 72.0 (67.6, 75.9) | 26.4 (22.5, 30.6) | 1.7 (0.9, 3.2) | |
| Female | 87.2 (84.8, 89.3) | 12.8 (10.7, 15.2) | 76.1 (72.2, 79.6) | 22.2 (19.1, 25.7) | 1.7 (0.8, 3.6) | ||
| Mexican American | Male | 93.8 (91.2, 95.7) | 6.2 (4.3, 8.8) | 87.8 (82.6, 91.6) | 12.1 (8.4, 17.3) | 0.1 (0.0, 0.7) | |
| Female | 93.5 (91.7, 94.9) | 6.5 (5.1, 8.3) | 87.3 (83.8, 90.1) | 12.4 (9.6, 15.9) | 0.3 (0.1, 0.8) | ||
| rs689453 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 8.7 (7.0, 10.8) | 91.3 (89.2, 93.0) | 0.8 (0.3, 1.8) | 15.9 (12.9, 19.5) | 83.3 (79.5, 86.5) | |
| Female | 7.0 (6.2, 8.0) | 93.0 (92.0, 93.8) | 0.3 (0.1, 0.7) | 13.6 (11.8, 15.5) | 86.2 (84.2, 87.9) | ||
| Non-Hispanic Black | Male | 4.5 (3.4, 5.9) | 95.5 (94.1, 96.6) | 0.2 (0.0, 1.0) | 8.5 (6.2, 11.6) | 91.3 (88.3, 93.6) | |
| Female | 5.6 (4.4, 7.0) | 94.4 (93.0, 95.6) | 0.5 (0.1, 1.4) | 10.2 (7.8, 13.3) | 89.3 (86.4, 91.6) | ||
| Mexican American | Male | 5.3 (3.6, 7.6) | 94.7 (92.4, 96.4) | 0.9 (0.3, 2.4) | 8.7 (6.2, 12.1) | 90.4 (86.5, 93.3) | |
| Female | 5.2 (3.9, 6.7) | 94.8 (93.3, 96.1) | 0.3 (0.1, 1.1) | 9.8 (7.5, 12.7) | 89.9 (87.0, 92.3) | ||
- Page last reviewed: March 16, 2009 (archived document)
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