OGG1 Allele and Genotype Frequencies

Available polymorphism(s)

rs number	Common Designations Nucleotide change Amino acid		Genotyping method
rs1052133	Ex6-315C>G	Ser326Cys Pro332Ala	TaqMan

 

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By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs1052133		C	G		CC	CG	GG
	Non-Hispanic White	78.5 (76.5, 80.5)	21.5 (19.5, 23.5)	<0.001	61.3 (57.9, 64.6)	34.4 (31.5, 37.5)	4.3 (3.3, 5.5)	<0.001	0.11
	Non-Hispanic Black	83.6 (82.2, 84.8)	16.4 (15.2, 17.8)		69.6 (67.3, 71.8)	28.0 (25.8, 30.3)	2.5 (1.6, 3.7)		0.14
	Mexican American	67.0 (64.8, 69.2)	33.0 (30.8, 35.2)		44.3 (40.8, 47.8)	45.5 (42.6, 48.4)	10.2 (9.0, 11.6)		0.12
	Total*	77.0 (75.3, 78.7)	23.0 (21.3, 24.7)		59.6 (56.8, 62.4)	34.8 (32.5, 37.1)	5.6 (4.7, 6.6)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1052133		C	G		CC	CG	GG
	12-19	76.9 (73.5, 80.0)	23.1 (20.0, 26.5)	0.955	58.6 (53.7, 63.4)	36.6 (32.6, 40.8)	4.8 (2.9, 7.7)	0.728
	20-39	77.0 (74.4, 79.4)	23.0 (20.6, 25.6)		59.5 (55.5, 63.5)	34.9 (31.6, 38.4)	5.6 (4.3, 7.2)
	40-59	77.5 (74.4, 80.3)	22.5 (19.7, 25.6)		61.2 (56.5, 65.6)	32.6 (28.2, 37.4)	6.2 (4.0, 9.5)
	>=60	76.6 (73.9, 79.1)	23.4 (20.9, 26.1)		58.4 (53.9, 62.7)	36.4 (32.4, 40.5)	5.2 (3.8, 7.1)
	Total	77.0 (75.3, 78.7)	23.0 (21.3, 24.7)		59.6 (56.8, 62.4)	34.8 (32.5, 37.1)	5.6 (4.7, 6.6)

* Includes all participants, regardless of race/ethnicity.

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By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1052133		C	G		CC	CG	GG
	Male	77.3 (74.9, 79.5)	22.7 (20.5, 25.1)	0.683	59.9 (56.4, 63.3)	34.8 (32.2, 37.4)	5.3 (4.1, 6.9)	0.876
	Female	76.8 (74.9, 78.6)	23.2 (21.4, 25.1)		59.4 (56.3, 62.4)	34.8 (32.1, 37.6)	5.8 (4.7, 7.1)
	Total	77.0 (75.3, 78.7)	23.0 (21.3, 24.7)		59.6 (56.8, 62.4)	34.8 (32.5, 37.1)	5.6 (4.7, 6.6)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs1052133			C	G	CC	CG	GG
	Non-Hispanic White	12-19	78.8 (74.4, 82.7)	21.2 (17.3, 25.6)	60.9 (54.1, 67.4)	35.8 (30.2, 41.7)	3.3 (1.5, 7.0)
		20-39	79.1 (75.6, 82.2)	20.9 (17.8, 24.4)	62.1 (56.4, 67.5)	33.9 (29.3, 38.8)	4.0 (2.7, 5.8)
		40-59	78.5 (74.8, 81.9)	21.5 (18.1, 25.2)	62.0 (56.2, 67.5)	33.0 (27.7, 38.8)	4.9 (2.7, 8.7)
		>=60	77.5 (74.7, 80.1)	22.5 (19.9, 25.3)	59.3 (54.7, 63.7)	36.4 (32.3, 40.6)	4.3 (2.9, 6.3)
	Non-Hispanic Black	12-19	84.4 (81.8, 86.7)	15.6 (13.3, 18.2)	70.8 (65.8, 75.4)	27.2 (22.2, 32.8)	2.0 (0.8, 4.6)
		20-39	82.4 (79.9, 84.6)	17.6 (15.4, 20.1)	67.4 (62.9, 71.6)	30.0 (25.8, 34.6)	2.6 (1.5, 4.5)
		40-59	86.0 (83.3, 88.3)	14.0 (11.7, 16.7)	74.8 (70.9, 78.3)	22.3 (18.9, 26.2)	2.9 (1.3, 6.5)
		>=60	81.6 (78.7, 84.2)	18.4 (15.8, 21.3)	65.1 (59.9, 70.1)	33.0 (28.3, 38.1)	1.9 (1.1, 3.2)
	Mexican American	12-19	70.0 (64.7, 74.8)	30.0 (25.2, 35.3)	47.7 (40.5, 54.9)	44.7 (39.5, 50.0)	7.7 (4.9, 11.9)
		20-39	66.5 (63.7, 69.1)	33.5 (30.9, 36.3)	44.3 (39.6, 49.0)	44.4 (39.9, 49.0)	11.4 (9.6, 13.4)
		40-59	65.4 (61.3, 69.3)	34.6 (30.7, 38.7)	40.7 (36.1, 45.5)	49.4 (45.5, 53.2)	9.9 (6.4, 14.9)
		>=60	67.4 (63.8, 70.9)	32.6 (29.1, 36.2)	45.4 (39.6, 51.4)	44.0 (37.9, 50.3)	10.5 (7.9, 13.9)

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By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs1052133			C	G	CC	CG	GG
	Non-Hispanic White	Male	78.5 (76.0, 80.8)	21.5 (19.2, 24.0)	61.1 (57.1, 64.9)	34.8 (31.6, 38.2)	4.1 (2.9, 5.6)
		Female	78.6 (76.4, 80.6)	21.4 (19.4, 23.6)	61.6 (57.8, 65.2)	34.0 (30.4, 37.8)	4.4 (3.2, 6.1)
	Non-Hispanic Black	Male	83.9 (82.1, 85.5)	16.1 (14.5, 17.9)	70.3 (67.6, 72.9)	27.1 (24.5, 29.8)	2.6 (1.5, 4.6)
		Female	83.3 (81.2, 85.2)	16.7 (14.8, 18.8)	68.9 (65.1, 72.5)	28.7 (25.1, 32.6)	2.3 (1.3, 4.1)
	Mexican American	Male	68.0 (65.5, 70.3)	32.0 (29.7, 34.5)	45.6 (41.3, 49.9)	44.8 (40.4, 49.2)	9.7 (8.2, 11.4)
		Female	66.1 (63.2, 68.8)	33.9 (31.2, 36.8)	42.9 (38.7, 47.3)	46.3 (42.9, 49.7)	10.8 (9.2, 12.6)

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