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PON1 Allele and Genotype Frequencies

This website is archived for historical purposes and is no longer being maintained or updated.

Available polymorphism(s)

rs number
Common Designations

Nucleotide change Amino acid

Genotyping method

rs662

Ex6+78A>G

Gln192Arg

TaqMan

rs854560

Ex3+18T>A

Leu55Met

TaqMan


By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs662 A G AA AG GG
Non-Hispanic White 68.5 (66.8, 70.3) 31.5 (29.7, 33.2) <0.001 47.3 (44.4, 50.3) 42.4 (39.4, 45.4) 10.3 (9.0, 11.7) <0.001 0.37
Non-Hispanic Black 32.9 (31.2, 34.6) 67.1 (65.4, 68.8) 11.3 (9.9, 12.8) 43.2 (41.5, 44.9) 45.5 (43.3, 47.7) 0.98
Mexican American 53.5 (51.9, 55.0) 46.5 (45.0, 48.1) 28.6 (25.4, 32.1) 49.6 (45.4, 53.9) 21.7 (20.1, 23.4) 0.90
Total* 61.5 (59.4, 63.6) 38.5 (36.4, 40.6) 40.0 (37.3, 42.8) 43.0 (40.8, 45.2) 17.0 (15.2, 19.0)
rs854560 A T AA AT TT
Non-Hispanic White 35.6 (33.6, 37.7) 64.4 (62.3, 66.4) <0.001 13.5 (12.2, 14.9) 44.3 (41.4, 47.2) 42.2 (39.0, 45.6) <0.001 0.40
Non-Hispanic Black 17.9 (16.5, 19.3) 82.1 (80.7, 83.5) 2.9 (2.3, 3.7) 30.0 (27.7, 32.3) 67.1 (64.6, 69.5) 0.30
Mexican American 23.0 (21.3, 24.8) 77.0 (75.2, 78.7) 5.0 (4.0, 6.1) 36.1 (33.2, 39.2) 58.9 (55.8, 61.9) 0.55
Total* 31.5 (29.4, 33.6) 68.5 (66.4, 70.6) 11.1 (10.0, 12.2) 40.8 (38.2, 43.5) 48.1 (44.8, 51.5)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs662 A G AA AG GG
12-19 62.6 (58.9, 66.2) 37.4 (33.8, 41.1) 0.044 40.2 (35.0, 45.6) 44.8 (39.8, 50.0) 15.0 (11.9, 18.7) 0.015
20-39 59.5 (56.8, 62.1) 40.5 (37.9, 43.2) 37.6 (34.2, 41.1) 43.8 (40.5, 47.2) 18.6 (16.0, 21.5)
40-59 61.8 (58.3, 65.1) 38.2 (34.9, 41.7) 41.1 (36.5, 45.9) 41.3 (36.9, 45.7) 17.6 (14.7, 21.0)
>=60 64.3 (61.7, 66.8) 35.7 (33.2, 38.3) 43.1 (39.5, 46.8) 42.4 (38.5, 46.4) 14.5 (12.0, 17.5)
Total 61.5 (59.4, 63.6) 38.5 (36.4, 40.6) 40.0 (37.3, 42.8) 43.0 (40.8, 45.2) 17.0 (15.2, 19.0)
rs854560 A T AA AT TT
12-19 31.7 (26.8, 37.1) 68.3 (62.9, 73.2) 0.330 10.4 (6.7, 15.9) 42.6 (36.9, 48.4) 47.0 (40.1, 54.0) 0.092
20-39 29.9 (26.5, 33.5) 70.1 (66.5, 73.5) 10.6 (8.4, 13.4) 38.6 (34.6, 42.7) 50.8 (45.6, 55.9)
40-59 32.0 (28.9, 35.3) 68.0 (64.7, 71.1) 11.3 (9.0, 14.1) 41.5 (37.5, 45.7) 47.2 (42.5, 51.9)
>=60 33.6 (31.9, 35.4) 66.4 (64.6, 68.1) 12.1 (10.1, 14.5) 43.0 (39.3, 46.9) 44.9 (41.9, 47.8)
Total 31.5 (29.4, 33.6) 68.5 (66.4, 70.6) 11.1 (10.0, 12.2) 40.8 (38.2, 43.5) 48.1 (44.8, 51.5)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs662 A G AA AG GG
Male 61.9 (58.7, 65.0) 38.1 (35.0, 41.3) 0.604 40.0 (35.5, 44.7) 43.8 (40.2, 47.5) 16.2 (14.0, 18.6) 0.268
Female 61.1 (58.9, 63.3) 38.9 (36.7, 41.1) 40.0 (37.4, 42.7) 42.2 (39.9, 44.4) 17.8 (15.7, 20.2)
Total 61.5 (59.4, 63.6) 38.5 (36.4, 40.6) 40.0 (37.3, 42.8) 43.0 (40.8, 45.2) 17.0 (15.2, 19.0)
rs854560 A T AA AT TT
Male 32.4 (29.1, 35.8) 67.6 (64.2, 70.9) 0.289 12.2 (10.4, 14.4) 40.3 (36.4, 44.2) 47.5 (42.4, 52.7) 0.222
Female 30.7 (28.9, 32.5) 69.3 (67.5, 71.1) 10.0 (8.6, 11.6) 41.4 (38.9, 43.9) 48.7 (46.0, 51.4)
Total 31.5 (29.4, 33.6) 68.5 (66.4, 70.6) 11.1 (10.0, 12.2) 40.8 (38.2, 43.5) 48.1 (44.8, 51.5)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs662 A G AA AG GG
Non-Hispanic White 12-19 72.6 (68.0, 76.7) 27.4 (23.3, 32.0) 51.8 (44.1, 59.4) 41.6 (33.8, 49.8) 6.7 (4.0, 10.8)
20-39 67.7 (65.4, 70.0) 32.3 (30.0, 34.6) 45.5 (41.5, 49.6) 44.4 (39.9, 48.9) 10.1 (8.1, 12.4)
40-59 67.0 (63.5, 70.4) 33.0 (29.6, 36.5) 46.8 (41.8, 51.9) 40.4 (35.5, 45.5) 12.7 (9.8, 16.5)
>=60 69.7 (66.7, 72.5) 30.3 (27.5, 33.3) 48.6 (44.0, 53.2) 42.1 (37.6, 46.8) 9.3 (7.1, 12.1)
Non-Hispanic Black 12-19 34.4 (31.5, 37.4) 65.6 (62.6, 68.5) 12.6 (9.7, 16.2) 43.6 (38.7, 48.7) 43.8 (39.4, 48.3)
20-39 32.4 (30.2, 34.6) 67.6 (65.4, 69.8) 11.0 (8.3, 14.4) 42.7 (40.0, 45.5) 46.3 (44.2, 48.4)
40-59 33.6 (30.0, 37.4) 66.4 (62.6, 70.0) 11.7 (8.7, 15.7) 43.7 (38.8, 48.6) 44.6 (39.5, 49.9)
>=60 31.2 (27.4, 35.2) 68.8 (64.8, 72.6) 9.6 (5.9, 15.3) 43.2 (36.9, 49.7) 47.2 (41.8, 52.7)
Mexican American 12-19 54.0 (50.0, 58.1) 46.0 (41.9, 50.0) 25.7 (20.0, 32.3) 56.8 (50.1, 63.2) 17.6 (13.8, 22.1)
20-39 52.7 (50.1, 55.2) 47.3 (44.8, 49.9) 27.9 (23.5, 32.8) 49.5 (44.5, 54.6) 22.6 (20.5, 24.8)
40-59 55.5 (50.8, 60.1) 44.5 (39.9, 49.2) 32.8 (27.7, 38.4) 45.3 (39.9, 50.8) 21.9 (16.9, 27.8)
>=60 51.5 (47.4, 55.5) 48.5 (44.5, 52.6) 29.4 (24.3, 35.1) 44.1 (36.8, 51.7) 26.5 (21.2, 32.5)
rs854560 A T AA AT TT
Non-Hispanic White 12-19 38.7 (33.2, 44.6) 61.3 (55.4, 66.8) 13.9 (9.1, 20.6) 49.7 (43.0, 56.5) 36.4 (29.3, 44.1)
20-39 34.7 (30.3, 39.3) 65.3 (60.7, 69.7) 13.5 (10.3, 17.6) 42.3 (37.3, 47.4) 44.2 (37.9, 50.6)
40-59 35.1 (31.4, 38.9) 64.9 (61.1, 68.6) 13.1 (10.3, 16.5) 44.0 (38.4, 49.7) 42.9 (37.2, 48.9)
>=60 36.2 (34.4, 38.1) 63.8 (61.9, 65.6) 13.7 (11.7, 16.1) 45.0 (41.6, 48.5) 41.3 (38.5, 44.1)
Non-Hispanic Black 12-19 17.3 (14.6, 20.3) 82.7 (79.7, 85.4) 2.9 (1.8, 4.5) 28.9 (23.7, 34.6) 68.3 (62.6, 73.4)
20-39 18.0 (16.3, 19.9) 82.0 (80.1, 83.7) 3.1 (2.0, 4.8) 29.8 (27.0, 32.8) 67.1 (64.1, 70.0)
40-59 18.0 (15.1, 21.4) 82.0 (78.6, 84.9) 2.6 (1.3, 5.2) 30.9 (25.4, 37.0) 66.5 (60.5, 72.0)
>=60 18.1 (16.0, 20.4) 81.9 (79.6, 84.0) 2.9 (1.6, 5.2) 30.4 (25.7, 35.5) 66.7 (62.2, 70.9)
Mexican American 12-19 24.9 (21.6, 28.6) 75.1 (71.4, 78.4) 5.6 (3.3, 9.3) 38.7 (34.0, 43.5) 55.7 (50.4, 60.9)
20-39 21.3 (18.7, 24.1) 78.7 (75.9, 81.3) 4.3 (2.9, 6.3) 34.1 (30.1, 38.3) 61.6 (57.0, 66.0)
40-59 24.8 (20.6, 29.5) 75.2 (70.5, 79.4) 5.4 (3.4, 8.4) 38.9 (33.2, 44.9) 55.8 (48.6, 62.7)
>=60 24.3 (21.5, 27.5) 75.7 (72.5, 78.5) 6.8 (3.6, 12.2) 35.2 (30.2, 40.4) 58.1 (54.2, 61.8)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs662 A G AA AG GG
Non-Hispanic White Male 68.1 (65.0, 71.1) 31.9 (28.9, 35.0) 46.4 (41.2, 51.6) 43.5 (38.7, 48.4) 10.2 (8.4, 12.2)
Female 68.9 (66.6, 71.2) 31.1 (28.8, 33.4) 48.3 (44.5, 52.0) 41.4 (37.8, 45.1) 10.4 (8.8, 12.2)
Non-Hispanic Black Male 32.6 (30.4, 34.9) 67.4 (65.1, 69.6) 11.1 (9.1, 13.6) 43.0 (39.9, 46.1) 45.9 (42.8, 49.1)
Female 33.1 (30.8, 35.5) 66.9 (64.5, 69.2) 11.4 (9.6, 13.5) 43.4 (40.5, 46.3) 45.2 (41.9, 48.6)
Mexican American Male 54.2 (51.5, 56.8) 45.8 (43.2, 48.5) 28.7 (24.2, 33.7) 50.9 (45.5, 56.3) 20.4 (18.0, 23.0)
Female 52.7 (50.5, 54.9) 47.3 (45.1, 49.5) 28.6 (24.9, 32.5) 48.3 (42.7, 53.9) 23.1 (20.0, 26.6)
rs854560 A T AA AT TT
Non-Hispanic White Male 35.9 (32.1, 40.0) 64.1 (60.0, 67.9) 14.5 (12.0, 17.4) 42.8 (38.7, 47.0) 42.7 (37.1, 48.4)
Female 35.3 (33.5, 37.2) 64.7 (62.8, 66.5) 12.5 (10.7, 14.5) 45.6 (42.7, 48.6) 41.9 (39.1, 44.6)
Non-Hispanic Black Male 16.9 (14.5, 19.6) 83.1 (80.4, 85.5) 2.4 (1.6, 3.6) 28.9 (24.8, 33.4) 68.7 (63.9, 73.1)
Female 18.8 (17.2, 20.4) 81.2 (79.6, 82.8) 3.3 (2.4, 4.7) 30.9 (28.3, 33.6) 65.8 (63.1, 68.5)
Mexican American Male 24.8 (22.8, 26.9) 75.2 (73.1, 77.2) 5.7 (4.5, 7.2) 38.2 (34.4, 42.2) 56.1 (52.3, 59.8)
Female 21.2 (19.4, 23.1) 78.8 (76.9, 80.6) 4.2 (3.4, 5.3) 34.0 (31.1, 37.0) 61.8 (58.6, 65.0)

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