PPARG Allele and Genotype Frequencies

Available polymorphism(s)

rs number	Common Designations Nucleotide change Amino acid		Genotyping method
rs1801282	Ex4-49C>G	Pro12Ala	TaqMan

 

---

By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs1801282		C	G		CC	CG	GG
	Non-Hispanic White	86.8 (85.7, 87.8)	13.2 (12.2, 14.3)	<0.001	75.8 (73.9, 77.6)	22.0 (20.2, 23.9)	2.2 (1.6, 3.0)	<0.001	0.93
	Non-Hispanic Black	97.5 (96.6, 98.1)	2.5 (1.9, 3.4)		95.0 (93.3, 96.3)	4.9 (3.7, 6.6)	0.0 (0.0, 0.4)		0.95
	Mexican American	87.6 (86.6, 88.6)	12.4 (11.4, 13.4)		76.7 (75.0, 78.3)	21.8 (20.4, 23.4)	1.5 (1.0, 2.2)		0.79
	Total*	88.4 (87.3, 89.4)	11.6 (10.6, 12.7)		78.5 (76.6, 80.3)	19.7 (18.0, 21.5)	1.8 (1.3, 2.4)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 Top of Page

---

By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1801282		C	G		CC	CG	GG
	12-19	88.6 (85.6, 91.0)	11.4 (9.0, 14.4)	0.689	78.2 (73.0, 82.6)	20.8 (16.7, 25.5)	1.1 (0.3, 3.3)	0.050
	20-39	88.0 (86.4, 89.5)	12.0 (10.5, 13.6)		78.7 (75.7, 81.4)	18.6 (15.8, 21.8)	2.6 (1.8, 3.8)
	40-59	88.1 (85.8, 90.0)	11.9 (10.0, 14.2)		77.7 (73.8, 81.2)	20.7 (17.3, 24.7)	1.5 (0.7, 3.6)
	>=60	89.3 (88.1, 90.4)	10.7 (9.6, 11.9)		79.4 (77.1, 81.6)	19.7 (17.4, 22.2)	0.9 (0.4, 1.8)
	Total	88.4 (87.3, 89.4)	11.6 (10.6, 12.7)		78.5 (76.6, 80.3)	19.7 (18.0, 21.5)	1.8 (1.3, 2.4)

* Includes all participants, regardless of race/ethnicity.

 Top of Page

---

By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs1801282		C	G		CC	CG	GG
	Male	88.6 (86.8, 90.1)	11.4 (9.9, 13.2)	0.713	79.3 (75.9, 82.3)	18.6 (15.6, 22.0)	2.1 (1.4, 3.1)	0.312
	Female	88.2 (86.8, 89.4)	11.8 (10.6, 13.2)		77.8 (75.6, 79.8)	20.8 (19.0, 22.7)	1.4 (0.9, 2.4)
	Total	88.4 (87.3, 89.4)	11.6 (10.6, 12.7)		78.5 (76.6, 80.3)	19.7 (18.0, 21.5)	1.8 (1.3, 2.4)

* Includes all participants, regardless of race/ethnicity.

 Top of Page

---

By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs1801282			C	G	CC	CG	GG
	Non-Hispanic White	12-19	86.5 (82.1, 90.0)	13.5 (10.0, 17.9)	74.5 (67.2, 80.6)	24.2 (18.6, 30.7)	1.4 (0.3, 5.6)
		20-39	86.3 (84.2, 88.2)	13.7 (11.8, 15.8)	76.1 (72.5, 79.4)	20.4 (17.3, 24.0)	3.5 (2.4, 5.0)
		40-59	86.4 (84.1, 88.5)	13.6 (11.5, 15.9)	74.7 (70.4, 78.7)	23.4 (19.2, 28.2)	1.9 (0.7, 4.5)
		>=60	88.2 (86.8, 89.4)	11.8 (10.6, 13.2)	77.4 (74.7, 79.8)	21.6 (19.1, 24.5)	1.0 (0.5, 2.1)
	Non-Hispanic Black	12-19	97.7 (95.5, 98.8)	2.3 (1.2, 4.5)	95.4 (91.1, 97.6)	4.6 (2.4, 8.9)	0.0 (NA)
		20-39	97.4 (96.6, 98.0)	2.6 (2.0, 3.4)	94.9 (93.4, 96.1)	5.0 (3.8, 6.5)	0.1 (0.0, 0.9)
		40-59	97.2 (95.6, 98.3)	2.8 (1.7, 4.4)	94.5 (91.3, 96.5)	5.5 (3.5, 8.7)	0.0 (NA)
		>=60	98.0 (95.9, 99.0)	2.0 (1.0, 4.1)	95.9 (91.9, 98.0)	4.1 (2.0, 8.1)	0.0 (NA)
	Mexican American	12-19	87.9 (84.7, 90.5)	12.1 (9.5, 15.3)	77.9 (73.0, 82.1)	20.0 (16.1, 24.6)	2.1 (0.7, 6.2)
		20-39	87.0 (85.3, 88.5)	13.0 (11.5, 14.7)	75.6 (72.6, 78.3)	22.8 (20.2, 25.5)	1.7 (1.1, 2.6)
		40-59	88.2 (86.6, 89.6)	11.8 (10.4, 13.4)	76.9 (73.8, 79.8)	22.5 (19.6, 25.7)	0.6 (0.2, 1.9)
		>=60	89.2 (85.3, 92.2)	10.8 (7.8, 14.7)	79.6 (73.1, 84.8)	19.2 (14.3, 25.4)	1.2 (0.2, 7.0)

 Top of Page

---

By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs1801282			C	G	CC	CG	GG
	Non-Hispanic White	Male	86.9 (84.5, 88.9)	13.1 (11.1, 15.5)	76.4 (72.2, 80.2)	20.8 (17.1, 25.1)	2.7 (1.8, 4.1)
		Female	86.7 (85.3, 88.1)	13.3 (11.9, 14.7)	75.2 (72.9, 77.3)	23.1 (21.1, 25.3)	1.7 (0.9, 3.2)
	Non-Hispanic Black	Male	97.2 (95.9, 98.1)	2.8 (1.9, 4.1)	94.6 (92.1, 96.3)	5.3 (3.7, 7.7)	0.1 (0.0, 0.8)
		Female	97.7 (96.9, 98.3)	2.3 (1.7, 3.1)	95.4 (93.8, 96.6)	4.6 (3.4, 6.2)	0.0 (NA)
	Mexican American	Male	88.2 (86.2, 89.9)	11.8 (10.1, 13.8)	78.0 (74.7, 81.0)	20.4 (17.8, 23.3)	1.6 (1.1, 2.4)
		Female	87.0 (85.1, 88.7)	13.0 (11.3, 14.9)	75.3 (72.1, 78.2)	23.4 (20.7, 26.3)	1.3 (0.6, 2.8)

 Top of Page