TLR4 Allele and Genotype Frequencies

Available polymorphism(s)

rs number	Common Designations Nucleotide change Amino acid		Genotyping method
rs4986790	Ex4+636A>G	Asp299Gly	TaqMan

 

By Race/Ethnicity

Variant	Race-ethnicity	Allele % (95% CI)		Chi-square P-value†	Genotype % (95% CI)			Chi-square P-value†	HW P-value‡
rs4986790		A	G		AA	AG	GG
	Non-Hispanic White	93.2 (92.5, 93.8)	6.8 (6.2, 7.5)	<0.001	86.9 (85.7, 88.1)	12.5 (11.3, 13.8)	0.5 (0.3, 1.0)	<0.001	0.50
	Non-Hispanic Black	92.5 (91.8, 93.2)	7.5 (6.8, 8.2)		85.7 (84.3, 87.0)	13.7 (12.3, 15.2)	0.6 (0.3, 1.2)		0.73
	Mexican American	97.5 (96.7, 98.2)	2.5 (1.8, 3.3)		95.1 (93.5, 96.4)	4.8 (3.6, 6.5)	0.0 (0.0, 0.2)		0.39
	Total*	93.6 (93.0, 94.2)	6.4 (5.8, 7.0)		87.7 (86.5, 88.9)	11.8 (10.7, 13.1)	0.5 (0.3, 0.8)

* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age^*

Variant	Age (years)	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs4986790		A	G		AA	AG	GG
	12-19	93.2 (91.2, 94.8)	6.8 (5.2, 8.8)	0.852	86.6 (82.6, 89.8)	13.3 (10.1, 17.3)	0.1 (0.0, 0.3)	0.013
	20-39	93.5 (92.4, 94.4)	6.5 (5.6, 7.6)		87.7 (85.6, 89.6)	11.5 (9.6, 13.9)	0.7 (0.3, 1.7)
	40-59	94.1 (92.6, 95.2)	5.9 (4.8, 7.4)		88.4 (85.5, 90.8)	11.3 (8.9, 14.2)	0.3 (0.1, 0.8)
	>=60	93.5 (91.6, 95.0)	6.5 (5.0, 8.4)		87.4 (84.2, 90.1)	12.1 (9.8, 14.9)	0.5 (0.1, 1.7)
	Total	93.6 (93.0, 94.2)	6.4 (5.8, 7.0)		87.7 (86.5, 88.9)	11.8 (10.7, 13.1)	0.5 (0.3, 0.8)

* Includes all participants, regardless of race/ethnicity.

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By Sex^*

Variant	Sex	Allele % (95% CI)		Chi-square P-value	Genotype % (95% CI)			Chi-square P-value
rs4986790		A	G		AA	AG	GG
	Male	93.6 (92.3, 94.6)	6.4 (5.4, 7.7)	0.904	87.7 (85.2, 89.8)	11.8 (9.7, 14.3)	0.5 (0.2, 1.0)	0.953
	Female	93.7 (93.1, 94.2)	6.3 (5.8, 6.9)		87.8 (86.7, 88.7)	11.8 (10.9, 12.8)	0.4 (0.2, 0.9)
	Total	93.6 (93.0, 94.2)	6.4 (5.8, 7.0)		87.7 (86.5, 88.9)	11.8 (10.7, 13.1)	0.5 (0.3, 0.8)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant	Race-ethnicity	Age (years)	Allele % (95% CI)		Genotype % (95% CI)
rs4986790			A	G	AA	AG	GG
	Non-Hispanic White	12-19	92.6 (89.3, 94.9)	7.4 (5.1, 10.7)	85.1 (78.7, 89.9)	14.9 (10.1, 21.3)	0.0 (NA)
		20-39	93.1 (91.8, 94.3)	6.9 (5.7, 8.2)	87.2 (84.6, 89.4)	11.9 (9.6, 14.8)	0.9 (0.3, 2.3)
		40-59	93.5 (91.8, 94.8)	6.5 (5.2, 8.2)	87.2 (84.0, 89.9)	12.5 (9.8, 15.7)	0.3 (0.1, 0.9)
		>=60	93.3 (91.2, 95.0)	6.7 (5.0, 8.8)	87.2 (83.6, 90.1)	12.2 (9.8, 15.2)	0.6 (0.2, 2.0)
	Non-Hispanic Black	12-19	92.1 (89.9, 93.9)	7.9 (6.1, 10.1)	84.8 (80.4, 88.4)	14.5 (10.8, 19.3)	0.6 (0.2, 2.1)
		20-39	91.8 (90.2, 93.1)	8.2 (6.9, 9.8)	84.3 (81.4, 86.8)	15.0 (12.5, 17.9)	0.7 (0.3, 1.9)
		40-59	93.8 (91.8, 95.4)	6.2 (4.6, 8.2)	88.5 (85.0, 91.2)	10.7 (8.2, 13.8)	0.8 (0.3, 2.3)
		>=60	93.1 (90.4, 95.1)	6.9 (4.9, 9.6)	86.2 (80.9, 90.2)	13.8 (9.8, 19.1)	0.0 (NA)
	Mexican American	12-19	98.2 (96.3, 99.1)	1.8 (0.9, 3.7)	96.4 (92.7, 98.3)	3.6 (1.7, 7.3)	0.0 (NA)
		20-39	97.3 (96.2, 98.0)	2.7 (2.0, 3.8)	94.6 (92.6, 96.1)	5.4 (3.9, 7.4)	0.1 (0.0, 0.4)
		40-59	97.7 (94.8, 99.0)	2.3 (1.0, 5.2)	95.4 (89.8, 98.0)	4.6 (2.0, 10.2)	0.0 (NA)
		>=60	97.2 (94.9, 98.5)	2.8 (1.5, 5.1)	94.7 (89.9, 97.2)	5.2 (2.6, 10.2)	0.2 (0.0, 1.4)

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By Race/Ethnicity and Sex

Variant	Race-ethnicity	Sex	Allele % (95% CI)		Genotype % (95% CI)
rs4986790			A	G	AA	AG	GG
	Non-Hispanic White	Male	93.0 (91.6, 94.3)	7.0 (5.7, 8.4)	86.6 (83.8, 89.0)	12.8 (10.4, 15.7)	0.5 (0.2, 1.2)
		Female	93.3 (92.5, 94.1)	6.7 (5.9, 7.5)	87.2 (85.8, 88.6)	12.2 (11.0, 13.6)	0.5 (0.3, 1.1)
	Non-Hispanic Black	Male	92.5 (91.3, 93.6)	7.5 (6.4, 8.7)	86.0 (83.5, 88.1)	13.2 (10.8, 15.9)	0.9 (0.4, 2.1)
		Female	92.5 (91.6, 93.4)	7.5 (6.6, 8.4)	85.5 (83.7, 87.0)	14.1 (12.6, 15.8)	0.4 (0.2, 1.0)
	Mexican American	Male	98.0 (97.2, 98.6)	2.0 (1.4, 2.8)	96.0 (94.4, 97.2)	4.0 (2.8, 5.6)	0.0 (NA)
		Female	97.1 (95.4, 98.1)	2.9 (1.9, 4.6)	94.2 (91.0, 96.3)	5.7 (3.6, 9.0)	0.1 (0.0, 0.4)

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