XRCC1 Allele and Genotype Frequencies
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This website is archived for historical purposes and is no longer being maintained or updated.
Available polymorphism(s)
| Common Designations | |||
|---|---|---|---|
|
rs number |
Nucleotide change | Amino acid |
Genotyping method |
|
rs1001581 |
IVS2-216G>A |
|
MGB Eclipse |
|
rs1799782 |
Ex6-22C>T |
Arg194Trp |
TaqMan |
|
rs25486 |
IVS9-59A>G |
|
TaqMan |
|
rs25487 |
Ex10-4G>A |
Arg399Gln |
TaqMan |
|
rs25489 |
Ex9+16G>A |
Arg280His |
TaqMan |
By Race/Ethnicity
| Variant | Race-ethnicity | Allele % (95% CI) |
Chi-square P-value† |
Genotype % (95% CI) |
Chi-square P-value† |
HW P-value‡ |
|||
|---|---|---|---|---|---|---|---|---|---|
| rs1001581 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 39.9 (38.0, 41.9) | 60.1 (58.1, 62.0) | <0.001 | 15.3 (13.6, 17.3) | 49.2 (46.0, 52.4) | 35.5 (32.5, 38.5) | <0.001 | 0.69 | |
| Non-Hispanic Black | 36.7 (34.9, 38.5) | 63.3 (61.5, 65.1) | 14.6 (13.1, 16.2) | 44.2 (41.7, 46.7) | 41.2 (38.6, 43.9) | 0.20 | |||
| Mexican American | 30.2 (27.8, 32.7) | 69.8 (67.3, 72.2) | 9.2 (7.6, 10.9) | 42.1 (38.8, 45.4) | 48.8 (44.9, 52.6) | 0.92 | |||
| Total* | 38.9 (37.5, 40.3) | 61.1 (59.7, 62.5) | 14.9 (13.6, 16.3) | 47.9 (45.6, 50.2) | 37.2 (35.0, 39.4) | ||||
| rs1799782 | C | T | CC | CT | TT | ||||
| Non-Hispanic White | 95.0 (94.4, 95.7) | 5.0 (4.3, 5.6) | <0.001 | 90.4 (89.1, 91.6) | 9.3 (8.1, 10.6) | 0.3 (0.1, 0.8) | <0.001 | 0.97 | |
| Non-Hispanic Black | 93.8 (92.9, 94.7) | 6.2 (5.3, 7.1) | 88.2 (86.6, 89.6) | 11.3 (10.0, 12.6) | 0.5 (0.2, 1.3) | 0.13 | |||
| Mexican American | 85.2 (83.6, 86.7) | 14.8 (13.3, 16.4) | 73.0 (70.7, 75.1) | 24.4 (23.0, 25.9) | 2.6 (1.8, 3.8) | 0.12 | |||
| Total* | 93.0 (92.3, 93.6) | 7.0 (6.4, 7.7) | 86.7 (85.6, 87.7) | 12.6 (11.6, 13.7) | 0.7 (0.5, 1.1) | ||||
| rs25486 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 64.0 (62.2, 65.8) | 36.0 (34.2, 37.8) | <0.001 | 40.6 (37.4, 43.8) | 46.9 (43.3, 50.5) | 12.5 (11.0, 14.3) | <0.001 | 0.70 | |
| Non-Hispanic Black | 75.9 (73.7, 77.9) | 24.1 (22.1, 26.3) | 57.9 (54.9, 60.8) | 35.9 (33.7, 38.3) | 6.2 (4.7, 8.0) | 0.26 | |||
| Mexican American | 74.2 (72.4, 76.0) | 25.8 (24.0, 27.6) | 55.3 (52.3, 58.3) | 37.8 (35.4, 40.3) | 6.9 (6.0, 7.9) | 0.88 | |||
| Total* | 66.4 (65.1, 67.6) | 33.6 (32.4, 34.9) | 44.0 (41.8, 46.2) | 44.7 (42.1, 47.2) | 11.3 (10.1, 12.6) | ||||
| rs25487 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 36.1 (34.3, 37.9) | 63.9 (62.1, 65.7) | <0.001 | 12.7 (11.1, 14.4) | 46.9 (43.3, 50.5) | 40.5 (37.3, 43.7) | <0.001 | 0.67 | |
| Non-Hispanic Black | 15.9 (14.4, 17.5) | 84.1 (82.5, 85.6) | 2.8 (2.0, 4.1) | 26.1 (24.2, 28.2) | 71.0 (68.6, 73.4) | 0.16 | |||
| Mexican American | 25.6 (23.9, 27.5) | 74.4 (72.5, 76.1) | 6.8 (5.8, 7.8) | 37.7 (35.3, 40.2) | 55.5 (52.6, 58.4) | 0.76 | |||
| Total* | 32.6 (31.2, 34.1) | 67.4 (65.9, 68.8) | 11.0 (9.8, 12.4) | 43.3 (40.6, 46.0) | 45.7 (43.2, 48.2) | ||||
| rs25489 | A | G | AA | AG | GG | ||||
| Non-Hispanic White | 4.0 (3.3, 4.8) | 96.0 (95.2, 96.7) | <0.001 | 0.1 (0.0, 0.3) | 7.8 (6.4, 9.4) | 92.2 (90.5, 93.5) | <0.001 | 0.99 | |
| Non-Hispanic Black | 3.5 (2.9, 4.2) | 96.5 (95.8, 97.1) | 0.2 (0.1, 0.4) | 6.5 (5.2, 8.0) | 93.3 (91.8, 94.5) | 0.25 | |||
| Mexican American | 12.4 (10.8, 14.2) | 87.6 (85.8, 89.2) | 1.6 (1.3, 2.1) | 21.6 (18.8, 24.6) | 76.8 (73.5, 79.8) | 0.44 | |||
| Total* | 4.7 (4.0, 5.4) | 95.3 (94.6, 96.0) | 0.2 (0.2, 0.4) | 8.8 (7.6, 10.2) | 90.9 (89.6, 92.1) | ||||
* Includes all U.S. race/ethnic groups.
† “other” race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.
By Age*
| Variant | Age (years) | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1001581 | A | G | AA | AG | GG | |||
| 12-19 | 36.0 (31.7, 40.5) | 64.0 (59.5, 68.3) | 0.360 | 13.4 (10.7, 16.5) | 45.2 (39.7, 50.8) | 41.4 (34.9, 48.3) | 0.539 | |
| 20-39 | 39.7 (37.4, 42.0) | 60.3 (58.0, 62.6) | 14.8 (12.7, 17.2) | 49.8 (46.4, 53.2) | 35.4 (32.2, 38.8) | |||
| 40-59 | 39.1 (36.3, 41.9) | 60.9 (58.1, 63.7) | 15.7 (13.4, 18.4) | 46.7 (42.9, 50.5) | 37.6 (33.5, 41.8) | |||
| >=60 | 39.0 (37.1, 41.0) | 61.0 (59.0, 62.9) | 15.1 (12.7, 17.9) | 47.8 (43.3, 52.3) | 37.1 (33.8, 40.4) | |||
| Total | 38.9 (37.5, 40.3) | 61.1 (59.7, 62.5) | 14.9 (13.6, 16.3) | 47.9 (45.6, 50.2) | 37.2 (35.0, 39.4) | |||
| rs1799782 | C | T | CC | CT | TT | |||
| 12-19 | 91.9 (89.9, 93.6) | 8.1 (6.4, 10.1) | 0.683 | 84.7 (81.0, 87.8) | 14.4 (11.4, 18.1) | 0.8 (0.3, 2.1) | 0.244 | |
| 20-39 | 93.1 (91.9, 94.0) | 6.9 (6.0, 8.1) | 86.7 (84.5, 88.6) | 12.8 (10.9, 14.9) | 0.6 (0.3, 1.0) | |||
| 40-59 | 93.2 (90.9, 95.0) | 6.8 (5.0, 9.1) | 87.4 (83.6, 90.4) | 11.7 (9.1, 14.8) | 1.0 (0.4, 2.2) | |||
| >=60 | 93.2 (91.9, 94.3) | 6.8 (5.7, 8.1) | 87.1 (84.6, 89.2) | 12.2 (10.1, 14.8) | 0.7 (0.3, 1.5) | |||
| Total | 93.0 (92.3, 93.6) | 7.0 (6.4, 7.7) | 86.7 (85.6, 87.7) | 12.6 (11.6, 13.7) | 0.7 (0.5, 1.1) | |||
| rs25486 | A | G | AA | AG | GG | |||
| 12-19 | 68.9 (64.1, 73.3) | 31.1 (26.7, 35.9) | 0.521 | 48.2 (42.3, 54.1) | 41.4 (37.5, 45.4) | 10.4 (7.1, 15.0) | 0.335 | |
| 20-39 | 66.0 (63.7, 68.3) | 34.0 (31.7, 36.3) | 42.8 (39.1, 46.6) | 46.4 (42.3, 50.6) | 10.8 (8.7, 13.2) | |||
| 40-59 | 65.8 (63.2, 68.3) | 34.2 (31.7, 36.8) | 44.2 (40.4, 48.1) | 43.1 (39.2, 47.1) | 12.7 (10.3, 15.4) | |||
| >=60 | 66.1 (64.2, 68.0) | 33.9 (32.0, 35.8) | 43.3 (40.5, 46.1) | 45.6 (42.3, 49.0) | 11.0 (9.0, 13.5) | |||
| Total | 66.4 (65.1, 67.6) | 33.6 (32.4, 34.9) | 44.0 (41.8, 46.2) | 44.7 (42.1, 47.2) | 11.3 (10.1, 12.6) | |||
| rs25487 | A | G | AA | AG | GG | |||
| 12-19 | 29.4 (24.8, 34.5) | 70.6 (65.5, 75.2) | 0.281 | 9.5 (6.3, 14.1) | 39.8 (36.1, 43.6) | 50.7 (44.5, 56.9) | 0.265 | |
| 20-39 | 32.7 (30.4, 35.2) | 67.3 (64.8, 69.6) | 10.3 (8.2, 12.8) | 44.9 (40.2, 49.7) | 44.8 (40.7, 49.0) | |||
| 40-59 | 33.6 (31.0, 36.2) | 66.4 (63.8, 69.0) | 12.7 (10.3, 15.4) | 41.8 (37.6, 46.1) | 45.5 (41.5, 49.6) | |||
| >=60 | 33.5 (31.5, 35.4) | 66.5 (64.6, 68.5) | 11.1 (8.8, 13.9) | 44.7 (41.0, 48.5) | 44.2 (41.3, 47.1) | |||
| Total | 32.6 (31.2, 34.1) | 67.4 (65.9, 68.8) | 11.0 (9.8, 12.4) | 43.3 (40.6, 46.0) | 45.7 (43.2, 48.2) | |||
| rs25489 | A | G | AA | AG | GG | |||
| 12-19 | 4.4 (3.4, 5.9) | 95.6 (94.1, 96.6) | 0.411 | 0.2 (0.0, 0.9) | 8.5 (6.7, 10.8) | 91.3 (88.8, 93.3) | 0.392 | |
| 20-39 | 5.2 (4.1, 6.6) | 94.8 (93.4, 95.9) | 0.2 (0.2, 0.3) | 10.0 (7.8, 12.8) | 89.8 (87.0, 92.0) | |||
| 40-59 | 4.2 (3.2, 5.6) | 95.8 (94.4, 96.8) | 0.2 (0.1, 0.8) | 7.9 (5.8, 10.7) | 91.8 (89.1, 93.9) | |||
| >=60 | 4.3 (3.5, 5.3) | 95.7 (94.7, 96.5) | 0.4 (0.1, 1.0) | 7.9 (6.1, 10.2) | 91.7 (89.7, 93.4) | |||
| Total | 4.7 (4.0, 5.4) | 95.3 (94.6, 96.0) | 0.2 (0.2, 0.4) | 8.8 (7.6, 10.2) | 90.9 (89.6, 92.1) | |||
* Includes all participants, regardless of race/ethnicity.
By Sex*
| Variant | Sex | Allele % (95% CI) |
Chi-square P-value |
Genotype % (95% CI) |
Chi-square P-value |
|||
|---|---|---|---|---|---|---|---|---|
| rs1001581 | A | G | AA | AG | GG | |||
| Male | 38.7 (36.4, 41.1) | 61.3 (58.9, 63.6) | 0.832 | 14.3 (12.2, 16.7) | 48.9 (45.1, 52.7) | 36.9 (33.3, 40.6) | 0.518 | |
| Female | 39.0 (37.3, 40.8) | 61.0 (59.2, 62.7) | 15.5 (14.1, 17.0) | 47.0 (44.0, 50.1) | 37.5 (34.6, 40.5) | |||
| Total | 38.9 (37.5, 40.3) | 61.1 (59.7, 62.5) | 14.9 (13.6, 16.3) | 47.9 (45.6, 50.2) | 37.2 (35.0, 39.4) | |||
| rs1799782 | C | T | CC | CT | TT | |||
| Male | 93.3 (92.0, 94.3) | 6.7 (5.7, 8.0) | 0.510 | 87.0 (84.8, 89.0) | 12.4 (10.7, 14.4) | 0.5 (0.3, 1.1) | 0.684 | |
| Female | 92.7 (91.7, 93.6) | 7.3 (6.4, 8.3) | 86.3 (84.8, 87.7) | 12.7 (11.6, 13.9) | 0.9 (0.4, 1.9) | |||
| Total | 93.0 (92.3, 93.6) | 7.0 (6.4, 7.7) | 86.7 (85.6, 87.7) | 12.6 (11.6, 13.7) | 0.7 (0.5, 1.1) | |||
| rs25486 | A | G | AA | AG | GG | |||
| Male | 65.7 (63.6, 67.7) | 34.3 (32.3, 36.4) | 0.356 | 43.1 (40.0, 46.2) | 45.2 (41.6, 48.8) | 11.7 (9.6, 14.2) | 0.652 | |
| Female | 67.0 (65.1, 68.9) | 33.0 (31.1, 34.9) | 44.9 (41.2, 48.7) | 44.2 (39.9, 48.5) | 10.9 (9.4, 12.6) | |||
| Total | 66.4 (65.1, 67.6) | 33.6 (32.4, 34.9) | 44.0 (41.8, 46.2) | 44.7 (42.1, 47.2) | 11.3 (10.1, 12.6) | |||
| rs25487 | A | G | AA | AG | GG | |||
| Male | 33.3 (31.1, 35.6) | 66.7 (64.4, 68.9) | 0.413 | 11.4 (9.2, 14.0) | 43.8 (40.3, 47.4) | 44.8 (41.6, 48.1) | 0.714 | |
| Female | 32.0 (30.0, 34.2) | 68.0 (65.8, 70.0) | 10.6 (9.1, 12.3) | 42.9 (38.6, 47.2) | 46.5 (42.6, 50.5) | |||
| Total | 32.6 (31.2, 34.1) | 67.4 (65.9, 68.8) | 11.0 (9.8, 12.4) | 43.3 (40.6, 46.0) | 45.7 (43.2, 48.2) | |||
| rs25489 | A | G | AA | AG | GG | |||
| Male | 4.6 (3.7, 5.8) | 95.4 (94.2, 96.3) | 0.984 | 0.3 (0.1, 0.6) | 8.8 (6.8, 11.2) | 91.0 (88.7, 92.8) | 0.927 | |
| Female | 4.7 (3.9, 5.5) | 95.3 (94.5, 96.1) | 0.2 (0.1, 0.4) | 8.9 (7.5, 10.5) | 90.9 (89.3, 92.3) | |||
| Total | 4.7 (4.0, 5.4) | 95.3 (94.6, 96.0) | 0.2 (0.2, 0.4) | 8.8 (7.6, 10.2) | 90.9 (89.6, 92.1) | |||
* Includes all participants, regardless of race/ethnicity.
By Race/Ethnicity and Age
| Variant | Race-ethnicity | Age (years) | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1001581 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 34.9 (27.2, 43.4) | 65.1 (56.6, 72.8) | 12.0 (7.4, 18.9) | 45.7 (38.9, 52.7) | 42.3 (31.7, 53.6) | |
| 20-39 | 41.9 (39.0, 44.9) | 58.1 (55.1, 61.0) | 16.1 (13.0, 19.7) | 51.7 (46.8, 56.5) | 32.2 (28.2, 36.6) | ||
| 40-59 | 40.3 (36.9, 43.7) | 59.7 (56.3, 63.1) | 16.1 (13.6, 19.1) | 48.2 (43.1, 53.4) | 35.6 (30.4, 41.2) | ||
| >=60 | 38.9 (37.3, 40.6) | 61.1 (59.4, 62.7) | 14.9 (12.3, 18.0) | 48.1 (42.6, 53.6) | 37.0 (33.5, 40.6) | ||
| Non-Hispanic Black | 12-19 | 36.6 (33.4, 39.9) | 63.4 (60.1, 66.6) | 14.5 (11.7, 17.8) | 44.2 (38.7, 49.7) | 41.3 (36.2, 46.6) | |
| 20-39 | 35.3 (32.1, 38.7) | 64.7 (61.3, 67.9) | 13.4 (11.3, 15.8) | 43.9 (40.5, 47.3) | 42.8 (38.1, 47.5) | ||
| 40-59 | 36.0 (32.8, 39.3) | 64.0 (60.7, 67.2) | 14.6 (11.5, 18.3) | 42.9 (38.0, 47.9) | 42.5 (37.9, 47.3) | ||
| >=60 | 42.2 (37.1, 47.4) | 57.8 (52.6, 62.9) | 18.4 (13.6, 24.5) | 47.5 (42.1, 53.0) | 34.1 (28.1, 40.5) | ||
| Mexican American | 12-19 | 31.4 (26.5, 36.7) | 68.6 (63.3, 73.5) | 8.7 (5.9, 12.8) | 45.3 (36.8, 54.1) | 45.9 (37.3, 54.8) | |
| 20-39 | 29.3 (26.6, 32.3) | 70.7 (67.7, 73.4) | 8.4 (6.5, 10.7) | 41.9 (37.3, 46.7) | 49.7 (44.9, 54.5) | ||
| 40-59 | 30.6 (26.8, 34.7) | 69.4 (65.3, 73.2) | 10.9 (8.5, 13.9) | 39.4 (33.2, 45.9) | 49.7 (43.1, 56.4) | ||
| >=60 | 31.3 (27.5, 35.5) | 68.7 (64.5, 72.5) | 10.3 (7.8, 13.5) | 42.1 (34.9, 49.8) | 47.6 (40.5, 54.8) | ||
| rs1799782 | C | T | CC | CT | TT | ||
| Non-Hispanic White | 12-19 | 94.2 (91.0, 96.3) | 5.8 (3.7, 9.0) | 88.6 (82.2, 92.9) | 11.1 (6.7, 17.9) | 0.3 (0.0, 1.9) | |
| 20-39 | 95.9 (95.2, 96.6) | 4.1 (3.4, 4.8) | 92.1 (90.7, 93.4) | 7.6 (6.4, 9.1) | 0.3 (0.1, 0.8) | ||
| 40-59 | 95.1 (92.5, 96.8) | 4.9 (3.2, 7.5) | 90.5 (86.1, 93.7) | 9.1 (6.2, 13.1) | 0.4 (0.0, 2.9) | ||
| >=60 | 93.9 (92.5, 95.1) | 6.1 (4.9, 7.5) | 88.2 (85.4, 90.5) | 11.5 (9.2, 14.2) | 0.3 (0.1, 1.2) | ||
| Non-Hispanic Black | 12-19 | 94.2 (92.6, 95.5) | 5.8 (4.5, 7.4) | 89.4 (87.0, 91.4) | 9.7 (7.8, 12.0) | 0.9 (0.2, 3.4) | |
| 20-39 | 93.7 (92.3, 94.8) | 6.3 (5.2, 7.7) | 87.5 (84.9, 89.7) | 12.3 (10.2, 14.7) | 0.2 (0.0, 1.1) | ||
| 40-59 | 92.6 (90.6, 94.3) | 7.4 (5.7, 9.4) | 86.0 (82.5, 88.9) | 13.2 (10.4, 16.6) | 0.7 (0.2, 3.5) | ||
| >=60 | 95.8 (94.1, 97.1) | 4.2 (2.9, 5.9) | 92.4 (89.3, 94.7) | 6.8 (4.7, 9.7) | 0.8 (0.4, 1.6) | ||
| Mexican American | 12-19 | 86.8 (82.8, 90.0) | 13.2 (10.0, 17.2) | 75.5 (68.9, 81.2) | 22.5 (17.3, 28.8) | 1.9 (0.7, 5.5) | |
| 20-39 | 84.9 (82.4, 87.1) | 15.1 (12.9, 17.6) | 72.8 (69.2, 76.1) | 24.3 (22.0, 26.9) | 2.9 (1.7, 4.9) | ||
| 40-59 | 85.4 (83.5, 87.1) | 14.6 (12.9, 16.5) | 72.3 (68.7, 75.7) | 26.0 (22.7, 29.7) | 1.6 (1.0, 2.5) | ||
| >=60 | 82.4 (76.6, 87.0) | 17.6 (13.0, 23.4) | 69.8 (61.0, 77.4) | 25.2 (18.7, 33.2) | 4.9 (2.4, 9.8) | ||
| rs25486 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 67.7 (59.5, 74.9) | 32.3 (25.1, 40.5) | 46.5 (36.7, 56.5) | 42.4 (36.9, 48.2) | 11.1 (6.3, 18.7) | |
| 20-39 | 62.5 (59.5, 65.4) | 37.5 (34.6, 40.5) | 37.5 (33.0, 42.2) | 50.0 (44.8, 55.2) | 12.5 (9.7, 16.0) | ||
| 40-59 | 63.9 (60.6, 67.1) | 36.1 (32.9, 39.4) | 41.5 (36.6, 46.6) | 44.8 (39.6, 50.1) | 13.7 (10.9, 17.0) | ||
| >=60 | 64.7 (62.9, 66.4) | 35.3 (33.6, 37.1) | 41.3 (38.3, 44.3) | 46.8 (42.8, 50.9) | 11.9 (9.7, 14.4) | ||
| Non-Hispanic Black | 12-19 | 76.1 (73.3, 78.6) | 23.9 (21.4, 26.7) | 60.0 (56.3, 63.6) | 32.2 (28.9, 35.6) | 7.8 (5.6, 10.8) | |
| 20-39 | 77.5 (74.8, 80.0) | 22.5 (20.0, 25.2) | 60.1 (55.6, 64.5) | 34.8 (31.1, 38.7) | 5.1 (4.1, 6.4) | ||
| 40-59 | 73.4 (70.4, 76.2) | 26.6 (23.8, 29.6) | 54.1 (50.1, 58.1) | 38.6 (33.3, 44.2) | 7.3 (4.2, 12.3) | ||
| >=60 | 74.8 (71.3, 78.0) | 25.2 (22.0, 28.7) | 55.0 (49.9, 60.0) | 39.7 (35.6, 44.0) | 5.3 (3.4, 8.3) | ||
| Mexican American | 12-19 | 74.3 (69.8, 78.3) | 25.7 (21.7, 30.2) | 54.5 (47.8, 61.0) | 39.7 (34.5, 45.0) | 5.9 (3.8, 9.1) | |
| 20-39 | 74.7 (72.4, 76.9) | 25.3 (23.1, 27.6) | 55.8 (52.1, 59.4) | 37.9 (34.4, 41.5) | 6.4 (4.9, 8.2) | ||
| 40-59 | 73.5 (70.0, 76.8) | 26.5 (23.2, 30.0) | 55.8 (49.3, 62.1) | 35.4 (29.4, 41.9) | 8.8 (7.6, 10.2) | ||
| >=60 | 73.2 (68.7, 77.2) | 26.8 (22.8, 31.3) | 53.6 (45.9, 61.1) | 39.2 (31.4, 47.5) | 7.2 (4.6, 11.1) | ||
| rs25487 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 32.1 (24.7, 40.4) | 67.9 (59.6, 75.3) | 10.7 (6.1, 18.0) | 42.8 (37.0, 48.8) | 46.5 (36.4, 57.0) | |
| 20-39 | 37.2 (34.3, 40.2) | 62.8 (59.8, 65.7) | 12.3 (9.3, 15.9) | 49.9 (44.4, 55.4) | 37.9 (33.3, 42.6) | ||
| 40-59 | 36.7 (33.8, 39.8) | 63.3 (60.2, 66.2) | 14.4 (11.7, 17.5) | 44.7 (39.4, 50.1) | 40.9 (36.1, 45.9) | ||
| >=60 | 35.6 (33.9, 37.3) | 64.4 (62.7, 66.1) | 12.2 (9.7, 15.1) | 46.9 (42.4, 51.5) | 40.9 (38.0, 43.9) | ||
| Non-Hispanic Black | 12-19 | 16.6 (14.0, 19.6) | 83.4 (80.4, 86.0) | 4.1 (2.4, 6.8) | 25.1 (20.5, 30.3) | 70.8 (65.8, 75.4) | |
| 20-39 | 14.5 (12.5, 16.7) | 85.5 (83.3, 87.5) | 2.5 (1.6, 3.8) | 24.0 (21.1, 27.2) | 73.5 (69.9, 76.8) | ||
| 40-59 | 17.1 (14.9, 19.5) | 82.9 (80.5, 85.1) | 2.5 (1.4, 4.4) | 29.1 (24.9, 33.6) | 68.4 (64.0, 72.5) | ||
| >=60 | 17.2 (13.8, 21.2) | 82.8 (78.8, 86.2) | 2.8 (1.2, 6.4) | 28.8 (24.4, 33.6) | 68.5 (62.5, 73.8) | ||
| Mexican American | 12-19 | 25.9 (21.9, 30.4) | 74.1 (69.6, 78.1) | 6.0 (3.8, 9.3) | 39.9 (35.5, 44.5) | 54.1 (47.8, 60.3) | |
| 20-39 | 25.2 (23.2, 27.3) | 74.8 (72.7, 76.8) | 6.3 (4.9, 8.2) | 37.7 (34.0, 41.6) | 56.0 (52.3, 59.5) | ||
| 40-59 | 25.8 (22.5, 29.4) | 74.2 (70.6, 77.5) | 7.9 (6.4, 9.8) | 35.7 (29.7, 42.1) | 56.4 (50.0, 62.6) | ||
| >=60 | 27.1 (23.3, 31.2) | 72.9 (68.8, 76.7) | 8.3 (5.5, 12.2) | 37.6 (30.0, 45.8) | 54.2 (46.9, 61.3) | ||
| rs25489 | A | G | AA | AG | GG | ||
| Non-Hispanic White | 12-19 | 3.9 (2.5, 6.0) | 96.1 (94.0, 97.5) | 0.0 (NA) | 7.8 (5.0, 12.0) | 92.2 (88.0, 95.0) | |
| 20-39 | 4.1 (3.1, 5.5) | 95.9 (94.5, 96.9) | 0.0 (NA) | 8.3 (6.1, 11.1) | 91.7 (88.9, 93.9) | ||
| 40-59 | 3.8 (2.6, 5.7) | 96.2 (94.3, 97.4) | 0.1 (0.0, 0.5) | 7.5 (5.0, 11.2) | 92.4 (88.7, 95.0) | ||
| >=60 | 3.9 (3.1, 5.0) | 96.1 (95.0, 96.9) | 0.4 (0.1, 1.2) | 7.1 (5.2, 9.8) | 92.5 (90.1, 94.3) | ||
| Non-Hispanic Black | 12-19 | 3.8 (2.5, 5.8) | 96.2 (94.2, 97.5) | 0.0 (NA) | 7.6 (5.0, 11.6) | 92.4 (88.4, 95.0) | |
| 20-39 | 3.4 (2.7, 4.3) | 96.6 (95.7, 97.3) | 0.4 (0.1, 1.6) | 6.1 (4.7, 7.9) | 93.5 (91.9, 94.9) | ||
| 40-59 | 2.7 (1.9, 3.9) | 97.3 (96.1, 98.1) | 0.2 (0.0, 2.0) | 4.9 (3.5, 6.9) | 94.8 (92.7, 96.3) | ||
| >=60 | 4.6 (2.9, 7.3) | 95.4 (92.7, 97.1) | 0.1 (0.0, 1.0) | 9.0 (5.5, 14.5) | 90.9 (85.6, 94.4) | ||
| Mexican American | 12-19 | 12.9 (9.6, 17.1) | 87.1 (82.9, 90.4) | 0.5 (0.1, 2.4) | 24.8 (18.2, 32.8) | 74.7 (66.7, 81.4) | |
| 20-39 | 13.2 (11.4, 15.3) | 86.8 (84.7, 88.6) | 2.2 (1.6, 3.0) | 22.2 (19.4, 25.1) | 75.7 (72.1, 78.9) | ||
| 40-59 | 10.4 (8.5, 12.7) | 89.6 (87.3, 91.5) | 1.3 (0.7, 2.3) | 18.3 (14.8, 22.3) | 80.4 (76.2, 84.0) | ||
| >=60 | 11.6 (9.5, 14.2) | 88.4 (85.8, 90.5) | 2.3 (1.1, 4.6) | 18.7 (15.2, 22.9) | 79.0 (74.8, 82.7) | ||
By Race/Ethnicity and Sex
| Variant | Race-ethnicity | Sex | Allele % (95% CI) |
Genotype % (95% CI) |
|||
|---|---|---|---|---|---|---|---|
| rs1001581 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 40.2 (37.1, 43.4) | 59.8 (56.6, 62.9) | 15.2 (12.4, 18.5) | 50.1 (44.8, 55.5) | 34.7 (29.8, 39.9) | |
| Female | 39.6 (37.3, 42.0) | 60.4 (58.0, 62.7) | 15.5 (14.0, 17.1) | 48.3 (44.7, 51.8) | 36.2 (32.5, 40.2) | ||
| Non-Hispanic Black | Male | 36.5 (34.3, 38.8) | 63.5 (61.2, 65.7) | 14.8 (13.0, 16.8) | 43.5 (39.3, 47.9) | 41.7 (37.8, 45.7) | |
| Female | 36.8 (35.0, 38.6) | 63.2 (61.4, 65.0) | 14.4 (12.5, 16.6) | 44.7 (42.6, 46.9) | 40.8 (38.7, 43.0) | ||
| Mexican American | Male | 30.2 (27.1, 33.4) | 69.8 (66.6, 72.9) | 8.6 (6.8, 11.0) | 43.1 (37.9, 48.3) | 48.3 (43.0, 53.7) | |
| Female | 30.2 (27.6, 33.0) | 69.8 (67.0, 72.4) | 9.7 (8.0, 11.7) | 41.1 (37.4, 44.8) | 49.2 (45.0, 53.5) | ||
| rs1799782 | C | T | CC | CT | TT | ||
| Non-Hispanic White | Male | 95.7 (94.4, 96.8) | 4.3 (3.2, 5.6) | 91.6 (88.9, 93.7) | 8.3 (6.2, 10.9) | 0.1 (0.0, 0.6) | |
| Female | 94.4 (93.6, 95.1) | 5.6 (4.9, 6.4) | 89.2 (87.9, 90.5) | 10.3 (9.1, 11.6) | 0.5 (0.1, 1.4) | ||
| Non-Hispanic Black | Male | 93.2 (91.5, 94.7) | 6.8 (5.3, 8.5) | 87.3 (84.5, 89.7) | 11.8 (9.7, 14.2) | 0.9 (0.3, 2.6) | |
| Female | 94.3 (93.5, 95.0) | 5.7 (5.0, 6.5) | 88.9 (87.4, 90.2) | 10.9 (9.6, 12.3) | 0.3 (0.1, 0.9) | ||
| Mexican American | Male | 85.5 (83.5, 87.3) | 14.5 (12.7, 16.5) | 73.1 (69.9, 76.0) | 24.7 (22.3, 27.3) | 2.2 (1.3, 3.5) | |
| Female | 84.9 (82.8, 86.8) | 15.1 (13.2, 17.2) | 72.9 (69.7, 75.8) | 24.1 (21.7, 26.7) | 3.1 (2.0, 4.7) | ||
| rs25486 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 62.8 (60.0, 65.7) | 37.2 (34.3, 40.0) | 39.4 (34.8, 44.2) | 46.9 (41.7, 52.2) | 13.7 (11.1, 16.7) | |
| Female | 65.1 (62.8, 67.4) | 34.9 (32.6, 37.2) | 41.7 (37.1, 46.4) | 46.8 (41.7, 52.1) | 11.5 (10.0, 13.1) | ||
| Non-Hispanic Black | Male | 75.3 (72.6, 77.8) | 24.7 (22.2, 27.4) | 56.8 (53.3, 60.3) | 36.9 (34.5, 39.4) | 6.3 (4.6, 8.5) | |
| Female | 76.3 (73.9, 78.6) | 23.7 (21.4, 26.1) | 58.7 (55.2, 62.2) | 35.1 (31.9, 38.5) | 6.1 (4.4, 8.4) | ||
| Mexican American | Male | 73.3 (70.6, 75.9) | 26.7 (24.1, 29.4) | 53.4 (48.9, 57.8) | 39.9 (36.0, 43.8) | 6.7 (5.6, 8.1) | |
| Female | 75.2 (73.3, 77.0) | 24.8 (23.0, 26.7) | 57.4 (54.4, 60.2) | 35.7 (33.3, 38.1) | 7.0 (6.0, 8.1) | ||
| rs25487 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 37.3 (34.5, 40.1) | 62.7 (59.9, 65.5) | 13.8 (11.2, 16.8) | 47.0 (42.1, 52.0) | 39.2 (34.9, 43.8) | |
| Female | 35.0 (32.8, 37.2) | 65.0 (62.8, 67.2) | 11.6 (10.2, 13.2) | 46.8 (41.7, 51.9) | 41.6 (37.2, 46.2) | ||
| Non-Hispanic Black | Male | 16.3 (14.1, 18.7) | 83.7 (81.3, 85.9) | 3.0 (2.0, 4.6) | 26.5 (23.4, 29.9) | 70.5 (66.5, 74.1) | |
| Female | 15.6 (13.8, 17.5) | 84.4 (82.5, 86.2) | 2.6 (1.7, 4.1) | 25.9 (23.0, 28.9) | 71.5 (68.3, 74.5) | ||
| Mexican American | Male | 26.5 (24.1, 28.9) | 73.5 (71.1, 75.9) | 6.6 (5.4, 8.0) | 39.8 (36.3, 43.4) | 53.6 (49.6, 57.6) | |
| Female | 24.7 (22.7, 26.8) | 75.3 (73.2, 77.3) | 7.0 (5.9, 8.2) | 35.5 (33.0, 38.1) | 57.5 (54.3, 60.7) | ||
| rs25489 | A | G | AA | AG | GG | ||
| Non-Hispanic White | Male | 3.9 (3.0, 5.2) | 96.1 (94.8, 97.0) | 0.1 (0.0, 0.5) | 7.6 (5.6, 10.3) | 92.3 (89.7, 94.3) | |
| Female | 4.0 (3.2, 5.0) | 96.0 (95.0, 96.8) | 0.1 (0.0, 0.4) | 7.9 (6.3, 9.8) | 92.0 (90.1, 93.7) | ||
| Non-Hispanic Black | Male | 2.9 (2.1, 4.0) | 97.1 (96.0, 97.9) | 0.3 (0.0, 1.7) | 5.3 (3.8, 7.2) | 94.4 (92.5, 95.9) | |
| Female | 4.0 (2.8, 5.6) | 96.0 (94.4, 97.2) | 0.2 (0.1, 0.8) | 7.5 (5.0, 11.0) | 92.3 (88.9, 94.7) | ||
| Mexican American | Male | 11.7 (10.0, 13.6) | 88.3 (86.4, 90.0) | 1.2 (0.7, 2.0) | 21.0 (17.8, 24.5) | 77.8 (74.2, 81.1) | |
| Female | 13.2 (10.9, 16.0) | 86.8 (84.0, 89.1) | 2.1 (1.4, 3.3) | 22.2 (18.5, 26.5) | 75.7 (70.9, 79.9) | ||
- Page last reviewed: March 16, 2009 (archived document)
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