Summaries of selected genetics, genomics, and family history-related studies using NHANES data, 2001-2009
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This Web page provides summaries of and links to selected articles on genetics, genomics, and family history-related studies conducted by CDC from 2001 to 2009 using National Health and Nutrition Examination Survey (NHANES) data.
Asthma
Title of Study |
Objective/Methods |
Findings |
---|---|---|
The association between family history of asthma and the prevalence of asthma among U.S. adults: National Health and Nutrition Examination Survey, 1999-2004 |
To assess how common asthma is in the U.S. and the association between family history of asthma and having asthma. Researchers analyzed National Health and Nutrition Examination Survey data from 1999 to 2004 for 15,008 adults aged 20 years or older, excluding people with a history of respiratory problems. Learn more about asthma |
Read the scientific article |
Folate
Title of Study |
Objective/Methods |
Findings |
---|---|---|
Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the United States: findings from the third National Health and Nutrition Examination Survey DNA Bank |
To estimate how common (or prevalent) variants of folate-related genes are in the U.S. population, and to examine how these genes affect serum folate and homocysteine concentrations in the blood. Abnormalities in the metabolism of folate and homocysteine are associated with disease and conditions (such as neural tube defects, dementia, cognitive function, osteoporosis, cancer, cardiovascular disease and stroke) that contribute significantly to morbidity and mortality among children and adults. Researchers used the DNA samples from 6,793 participants in NHANES III (collected from 1991 to 1994) for this study. They genotyped these samples for four variants in genes coding for folate pathway enzymes: 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase reductase (MTRR) A66G, and cystathionine-beta-synthase (CBS) 844ins68. Learn more about folic acid and birth defects. |
Read the scientific article |
Iron Overload
Title of Study |
Objective/Methods |
Findings |
---|---|---|
Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States. |
To estimate how common (or prevalent) two mutations of the Hemochromatosis (HFE) gene, which is crucial for iron metabolism, are in the U.S. population. Researchers used the DNA samples from 5,171 participants in NHANES III (collected from 1992 to 1994) for this study. Learn about hemochromatosis. Learn about the HFE gene. |
Read the scientific article |
Title of Study |
Objective/Methods |
Findings |
---|---|---|
HFE genotype and transferrin saturation in the United States. |
To examine the association between hereditary hemachromotosis (HFE) genotypes and transferrin saturation (an indicator of circulating iron) in the U.S. population by race and ethnic group, age, and sex. Researchers used the DNA samples from 5,171 participants in NHANES III (collected from 1992 to 1994) for this study. Learn about hemochromatosis. Learn about the HFE gene. |
Read the scientific article |
Osteoporosis
Title of Study |
Objective/Methods |
Findings |
---|---|---|
Prevalence, family history, and prevention of reported osteoporosis in U.S. women. |
To assess how common osteoporosis is in the U.S., the association between family history of osteoporosis and having osteoporosis, and the likelihood that women at high familial risk of osteoporosis report preventive behaviors. Researchers analyzed National Health and Nutrition Examination Survey data from 1999 to 2004 for 8,073 women aged 20 years or older Learn more about osteoporosis |
Read the scientific article |
- Page last reviewed: March 1, 2011 (archived document)
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