Epidemiologic Notes and Reports Antibody Response to A/Taiwan/
86 (H1N1) Virus in Young Adults Receiving Supplemental Monovalent
A/
Taiwan/86 Influenza Vaccine Following Trivalent
Influenza Vaccine
In accordance with recent recommendations (1), monovalent
A/Taiwan/86 (H1N1) influenza vaccine was given to U.S. Air Force
recruits who had been vaccinated 2 to 3 months previously with the
1986/87 trivalent influenza vaccine. Thirty-four recruits
volunteered
sera for antibody studies of immune response. At the time the
A/Taiwan/86 vaccine was administered, 100% of the recruits had
serum
hemagglutination-inhibition (HI) antibody titers of greater than
or
equal to 32 to the A/Chile/83 (H1N1) virus included in the
trivalent
vaccine, but only 45% had such titers to the A/Taiwan/86 strain.
Following immunization with the supplemental monovalent vaccine,
the
proportion of recruits with HI antibody titers of greater than or
equal to 32 against A/Taiwan/86 virus increased to 100%, and 92%
had
HI titers greater than or equal to 128 (Table 1).
Reported by G Meiklejohn, MD, Patricia Graves, School of Medicine,
Univ of Colorado Health Sciences Center, Denver, Col G Hutchison,
Lowry Air Force Base, Colorado; Lt Col M Evans, MD, Lackland Air
Force
Base, Texas; Influenza Br, Div of Viral Diseases, Center for
Infectious Diseases, CDC.
Editorial Note
Editorial Note: The above findings are consistent with previous
reports (2,3) that the A/Chile/83 component of the 1986/87
trivalent
vaccine may provide inadequate protection against the A/Taiwan/86
virus; protection may be boosted by use of the monovalent
A/Taiwan/86
vaccine as recommended (1). Because all recently reported
outbreaks
of influenza A/Taiwan/86-like virus, where laboratory confirmation
has
been obtained, have occurred in children or young adults, it is
particularly important that high-risk individuals in these age
groups
be given priority for vaccination with the supplemental A/Taiwan/86
vaccine. (See "Update of Influenza Activity, Availability of
Influenza Vaccines, and Recommendations and Precautions for the Use
of
Amantadine", pp. 805-807.)
CDC. Antigenic variation of recent influenza A(H1N1) viruses.
MMWR
1986;35:510-2.
CDC. Influenza activity in civilian and military populations
and
key points for use of influenza vaccines. MMWR 1986;35:729-31.
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