Notice to Readers
Revised Dosing Regimen for Malaria Prophylaxis with Mefloquine
A U.S. interagency group on malaria prevention has recently
reviewed documented experience on the effectiveness and tolerance
of mefloquine (Lariam((R))) for malaria prophylaxis. Based on
this review, the group has proposed a change in the dosing
regimen for malaria prophylaxis with mefloquine. Consequently,
CDC has revised the dosing recommendations for mefloquine use.
The new regimen consists of a single dose of mefloquine to be
taken weekly, starting 1 week before travel. Prophylaxis should
be continued weekly during travel in malarious areas and for 4
weeks after a person leaves such areas.
This notice updates the information in the following
publications:
CDC. Recommendations for the prevention of malaria among
travelers. MMWR 1990;39(no. RR-3):4.
CDC. Health information for international travel, 1990.
Atlanta: US Department of Health and Human Services, Public
Health Service, 1990:98; DHHS publication no. (CDC)90-8280.
Detailed recommendations for the prevention of malaria may be
obtained 24 hours a day by calling the CDC Malaria Hotline at
(404) 332-4555.
Information about the availability of mefloquine can be
obtained from the manufacturer at (800) 526-6367.
Reported by: Malaria Br, Div of Parasitic Diseases, Center for
Infectious Diseases, CDC.
Disclaimer
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