In the MMWR Recommendations and Reports, "Prevention of
Hepatitis A Through Active or Passive Immunization --
Recommendations
of the Advisory Committee on Immunization Practices (ACIP)," the
second full paragraph on page 12 (i.e., the last paragraph in the
section titled "Immune Globulin") contained errors regarding the
recommended delay between administration of immune globulin and
measles-mumps-rubella vaccine. The paragraph should read: "IG does
not interfere with the immune response to either oral poliovirus
vaccine or yellow fever vaccine, or, in general, to inactivated
vaccines. However, IG can interfere with the response to other
live, attenuated vaccines (e.g., measles-mumps-rubella {MMR} and
varicella) when vaccines are administered individually or as
combination vaccines. Administration of MMR should be delayed for
at least 3 months, and varicella vaccine should be delayed for at
least 5 months, after administration of IG for hepatitis A
prophylaxis. IG should not be administered within 2 weeks after the
administration of MMR or within 3 weeks after administration of
varicella vaccine unless the benefits of IG administration exceed
the benefits of vaccination (77). If IG is administered within 2
weeks after administration of MMR or within 3 weeks after
administration of varicella vaccine, the person should be
revaccinated, but not sooner than 3 months after the IG
administration for MMR or 5 months for varicella vaccine (77)."
An additional reference for this information is CDC.
Prevention of varicella: recommendations of the Advisory Committee
on Immunization Practices (ACIP). MMWR 1996;45(no. RR-11).
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