General Information

Balamuthia mandrillarisis a free-living ameba (a single-celled living organism) found in the environment. It is one of the causes of granulomatous amebic encephalitis (GAE), a serious infection of the brain and spinal cord ^1,2,5,6. Balamuthia is thought to enter the body when soil containing Balamuthia comes in contact with skin wounds and cuts, or when dust containing Balamuthia is breathed in or gets in the mouth ^1,2. The Balamuthia amebas can then travel to the brain through the blood stream and cause GAE ⁴. GAE is a very rare disease that is usually fatal.

Scientists at the Centers for Disease Control and Prevention (CDC) first discovered Balamuthia mandrillaris in 1986. The ameba was found in the brain of a dead mandrill baboon ^2,7. After extensive research, B. mandrillaris was declared a new species of ameba in 1993 ⁷. Since then, more than 200 cases of Balamuthia infection have been diagnosed worldwide, with at least 70 cases reported in the United States ². Little is known at this time about how a person becomes infected ^{1, 3}.

Balamuthia has been found in dust and soil in many places around the world ^{1, 2, 7}. It is possible that Balamuthia may also live in water.

Balamuthia infection is not spread from person to person.

Balamuthia is thought to enter the body when soil containing Balamuthia comes in contact with skin wounds and cuts, or when dust containing Balamuthia is breathed in or gets in the mouth ^1,2. Once inside the body, the amebas can travel through the blood stream to the brain, where they cause GAE ^1,5,6. There are also a few reports of dogs that might have become infected after swimming in ponds ⁷.

Balamuthia infection can occur at any time of year ⁷.

The symptoms of Balamuthia infection can begin with a skin wound on the face, chest, torso, arms, or legs. If the infection involves the brain, the disease it causes is called granulomatous amebic encephalitis (GAE) ^5,6. Diagnosis of Balamuthia GAE can be difficult, but some early symptoms might include:

• Headaches
• Stiff neck or head and neck pain with neck movement
• Sensitivity to light
• Nausea
• Vomiting
• Lethargy (tiredness)
• Low-grade fever

Other signs of Balamuthia GAE might include:

• Behavioral changes
• Seizures
• Weight loss
• Partial paralysis
• Difficulty speaking in full sentences
• Difficulty walking

The disease might appear mild at first but can become more severe over weeks to several months ^6,7. Often the disease is fatal ⁷, with a death rate of more than 89% ¹. Overall, the outlook for people who get this disease is poor, although early diagnosis and treatment may increase the chances for survival ¹.

It can take weeks to months to develop the first symptoms of Balamuthia GAE after initial exposure to the amebas ^1,2.

GAE is chronic and symptoms develop over a period of several weeks to as long as 2 years. Although Balamuthia GAE is often fatal ², there are several recorded cases of Balamuthia infection where the patients survived after long-term treatment with multiple drugs ^3,6. In some of those cases, the patients were able to return to normal, functioning lives ^1,2.

Balamuthia can infect anyone; this includes persons that are healthy or persons with weakened immune systems (such as persons with HIV/AIDS, cancer, liver disease, diabetes mellitus and/or persons taking immunosuppressive drugs following organ transplantation) ^1,2,5,6.

Contact your healthcare provider as soon as possible if you think you may have a Balamuthia infection.

Doctors and scientists must use special research tests to identify Balamuthia. These tests are not widely available, but CDC is available to help with testing ^1,2,6.

Currently, treatment recommendations include the use of a combination of several drugs. Most cases of Balamuthia are diagnosed right before death or after the patient has died ^3,6,7. This delay in diagnosis limits the amount of experience doctors have using different drugs to treat Balamuthia infection ¹. Current treatment plans are based on lab studies of the ameba and the few cases where the patients have survived.

No. There have been no reports of a Balamuthia infection spreading from one person to another except through organ donation/transplantation.

Currently, there are no known ways to prevent infection with Balamuthia since it is unclear how and why some people become infected while others do not. Research is currently underway to learn more about Balamuthia in hopes of finding ways to prevent future infections.