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Baclofen
From WikEM
Contents
Administration
- Type: Muscle relaxant/anti-spasmodic
- Dosage Forms:
- Routes of Administration: oral, intrathecal
- Common Trade Names:
Adult Dosing
- 5-20mg PO 3-4 times/day
- maintenance intrathecal rate after titration: 22 to 1400 mcg/day
Pediatric Dosing
- 2-7yo: 10 to 15 mg/day PO in 2-3 divided doses, titrate to max 40mg/day in 3-4 divided doses
- >7 yo: 10 to 15 mg/day PO in 2-3 divided doses, titrate to max 60mg/day in 3-4 divided doses
- <12 yo: maintenance intrathecal rate after titration- 24 to 1199 mcg/day
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk minimal
Renal Dosing
- CrCl 50-80 mL/min: reduce dose by 1/3
- CrCl 30-50 mL/min: reduce dose by 1/2
- CrCl <30 mL/min: reduce dose by 2/3
- If HD, use intrathecal with caution, likely reduce dose
Hepatic Dosing
- No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- GI bleed
- Coma
- Seizure
- Aseptic meningitis
- Pneumonia
- Withdrawal
Common
- Hypotension
- Nausea/vomiting, constipation
- Dizziness, somnolence, asthenia, poor muscle tone
- Urinary complications
Pharmacology
- Half-life: 5 hours (oral), 1.5-4 hours (intrathecal)
- Metabolism: Hepatic (15%)
- Excretion: Mostly renal
Mechanism of Action
- GABA agonist
