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Baclofen toxicity
From WikEM
Contents
Background
- Indications include MS, muscle spasticity pain
- GABAb receptor agonist
- Most excretion is renal
Clinical Features
- nausea and vomiting
- Drowziness, dizziness
- Seizures, delirium, altered mental status, coma
- Bradycardia, hypotension OR hypertension, respiratory compromise
- Hypothermia
Differential Diagnosis
Evaluation
- Diagnosis of exclusion
Management
- Activated charcoal for recent ingestion
- Supportive care:
- IV fluids, respiratory care
- Vasopressors for persistent hypotension
- Benzodiazepines for seizures
- Hemodialysis for very severe toxicity
Disposition
See Also
References
- Jung, M. “Baclofen Overdoses”. Maryland Poison Center, University of Maryland School of Pharmacy. www.mdpoison.com Accessed April 29th, 2014.
- Nicola Y Leung, Ian M Whyte, Geoffrey K Isbister Baclofen overdose: defining the spectrum of toxicity. Emerg Med Australas: 2006, 18(1);77-82
