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Bumetanide
From WikEM
Contents
General
- 80-100% oral bioavailability as opposed to furosemide[1]
Administration
- Type: Loop diuretic
- Dosage Forms:
- Routes of Administration: IV, PO
- Common Trade Names: Bumex
Adult Dosing
40mg furosemide = 20mg torsemide = 1mg bumetanide = 50 mg ethacrynic acid
- 0.5 to 1 mg IV or 0.5-2mg PO. If inadequate response, repeat q2-3 hours to maximum of 10 mg per day
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: use lowest dose necessary, titrate slowly
Contraindications
- Allergy to class/drug
- Anuria
- Hepatic coma
- Severe electrolyte depletion
Adverse Reactions
Serious
- SJS
- Encephalopathy
- Thrombocytopenia
Common
- Hypotenchion
- Hypouricemia, hypokalemia, hypochloremia
- Cramps
- Dizziness, headache
- Nausea
Pharmacology
- Rapid onset
- Half-life: 1-6 hours
- Metabolism:
- Excretion: Mostly renal
Mechanism of Action
- Inhibits the reabsorption of sodium and chloride in the ascending limb of the loop of Henle
Comments
See Also
References
- ↑ Asare K. Management of Loop Diuretic Resistance in the Intensive Care Unit. Am J Health Syst Pharm. 2009;66(18):1635-1640.
