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Ceftaroline fosamil
From WikEM
Contents
General
- Type: 5th Generation Cephalosporin
- Dosage Forms: IV
- Common Trade Names: Teflro
Adult Dosing
Community Acquired Pneumonia
- 600mg IV q12h x5-7 days
Cellulitis
- 600mg IV q12h x5-14 days
Renal Dosing
- CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h
Hepatic Dosing
- No adjustment
Pediatric Dosing
- Currently no pediatric dosing for this drug.
Special Populations
- Pregnancy Rating:B
- Lactation: Safety Unknown
- Renal Dosing
- Adult: CrCl 30-50: 400mg q12h; CrCl 15-30: 300mg q12h; ESRD/HD: 200mg q12h
- Pediatric: Drug not available for pediatrics
- Hepatic Dosing
- Adult: No Adjustment
- Pediatric: NA
Contraindications
- Allergy to class/drug (see also Cephalosporin Cross-reactivity)
- Caution if hypersensitive to beta-lactams
- Caution if recent antibiotic-associated colitis history
Adverse Reactions
Serious
- Anaphylaxis
- Hypersensitivity Reaction
- Clostridium difficile associated diarrhea
- SUPERINFECTION
- Hemolytic Anemia
Common
- Diarrhea
- Nausea
- Rash
- Constipation
- Vomiting
- ALT, AST elevated
- Hypokalemia
- Phlebitis
Pharmacology
- Half-life: 2.6 Hours
- Metabolism: Hydrolysis; CYP450: none; prodrug converted to ceftaroline
- Excretion: Urine primarily
- Mechanism of Action: Bactericidal, inhibits cell wall mucopeptide synthesis
