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Fluconazole
From WikEM
Contents
General
- Type: Antifungal
- Dosage Forms: IV; PO
- Common Trade Names: Diflucan
Adult Dosing
General
Candidiasis, oropharyngeal/esophageal
- 100mg PO qday x 2 week to prevent relapse
- Uncomplicated: 150mg PO x 1
Pediatric Dosing
Candidiasis, oropharyngeal/esophageal:
- > 14 days old: 6mg/kg PO x 1, then 3mg/kg q24h x 7-14 days, max: 100mg/day
Tinea Capitis: > 14 days old: 3-6mg/kg PO q24h x 6 weeks
Special Populations
- Pregnancy Rating: D
- Lactation Risk Categories: safety unknown
- Renal Dosing
- Adult:CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
- Pediatric: CrCrl < 50, give usual loading dose x 1 then decrease dose 50%
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- hepatotoxicity
- seizures
- leukopenia
- thrombocytopenia
- anaphylaxis
- steven-johnson syndrome
- QT prolongation
Common
- Nausea
- Rash
- Headache
- vomiting
- diarrhea
- Transaminitis
Pharmacology
- Half-life: 30 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action: inhibits cytochrome P450 and sterol c-14 alpha-demethylation
Authors
Babak Missaghi, Colin Hoff, Neil Young, Daniel Ostermayer, Claire, Ross Donaldson
