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Meclizine
From WikEM
Contents
General
- Type: Antihistamine, H1 antagonist
- Dosage Forms: 12.5, 25, 32mg oral tablet; 25mg oral chewable tablet
- Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time
Adult Dosing
Vertigo
- 25mg PO QID
Motion Sickness
- 25-100mg PO 1 hour before activity. May repeat q24h
Pediatric Dosing
- >= 12 yrs old: Adult dosing
- < 12 yrs: No dosing specified in drug insert
Special Populations
- Pregnancy Rating: B
- Lactation: Excretion in breast milk unknown
- Renal Dosing: n/a
- Hepatic Dosing: n/a
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- CNS depression
- Caution in asthma, glaucoma, BPH, pyloric obstruction
Common
- Drowsiness, fatigue
Pharmacology
- Onset: 1 hour
- Half-life: 5 hours
- Metabolism: Hepatic
- Excretion: Urine and feces
- Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways
See Also
References
Lexicomp
Authors
Joe Carpenter, Ross Donaldson, Daniel Ostermayer, Neil Young
