Minimum Inhibitory Concentrations Predicted by the Penicillin Binding Protein Type

An isolate’s Penicillin-Binding Protein (PBP) type, based upon the PBP proteins 1a, 2b and 2x, predict a specific level of resistance to penicillin and other critical antibiotics. Below are minimum inhibitory concentrations (MIC) tables for reference.^{1, 2}

• Excel File (includes all MIC tables) Updated June 2016
• PDF Files Updated June 2016
  • Amoxicillin
  • Cefotaxime
  • Ceftriaxone Narrow
  • Ceftriaxone Wide
  • Cefuroxime
  • Meropenem
  • Penicillin

Below are links to protein sequences (.faa files) referenced in the paper. The downloadable files below can be run on multiple open source platforms, including EMBOSS, Biostrings (withing Bioconductor), and Clustal Omega. Updated June 2016

• PBP1a.faa
• PBP2b.faa
• PBP2x.faa

Footnote

¹Metcalf BJ, Gertz RE Jr, Gladstone RA, et al. Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA. Clin Microbiol Infect. 2016 Jan;22 (1):60 e9—60.

²Li Y, Metcalf BJ, Chochua S, et al. Penicillin-binding protein transpeptidase signatures for tracking and predicting β-lactam resistance levels in Streptococcus pneumoniae. mBio. 2016 Jun 14; 7(3):60 pii:e00756–16.