Avascular necrosis of hip

Background

Traumatic and nontraumatic causes can lead to an insult to the blood supply of the joint. The ischemia causes death of osteocytes and bone marrow that leads to necrosis and eventual collapse of the dead segment.

Kupe MD. Hip Fracture. http://drkupe.blogspot.com/2011/03/hip-fracture.html. Accessed July 31, 2016.

Plain XR Osteonecrosis Femur by JMarchn(own work)

MRI Osteonecrosis Femur by JMarchn (ownwork)

Epidemiology

• Estimate of 10,000 to 20,000 new cases per year
• Responsible for about 10% of all total hip replacements
• Patients typically diagnosed before 40 years of age

Etiologies

Traumatic causes

• Femoral neck fracture/dislocation

Non-traumatic causes

• Use of corticosteroids, alcohol, tobacco
• Systemic lupus erythematosus
• Sickle cell disease
• Chronic Kidney Disease
• Pancreatitis
• Radiation therapy
• HIV
• Caisson Disease (aka Dysbarism)
• Legg-Calve-Perthes disease
• Idiopathic

Clinical Features

• Limp
• Limited range of motion of joint, both active and passive
• Pain: Knee, Thigh, and/or Groin
• Wasting of local musculature
• Asymmetric leg length

Differential Diagnosis

Hip pain

• Femur fracture
• Hip dislocation
• Hip bursitis
• Psoas abscess
• Piriformis syndrome
• Meralgia paresthetica
• Septic Arthritis (Hip)
• Obturator nerve entrapment
• Pelvic fractures
  • Acetabular pelvic fractures
  • Open book pelvic fracture
  • Straddle pelvic fracture
  • Pelvic avulsion fracture
• Avascular necrosis of hip

Evaluation

• Plain XR is poorly sensitive in early stages, as low as 41%
  • AP and Frog leg views
• MRI ~90% sensitivity and specificity
  • Best test
• Bone Scan (aka Bone Scintigraph)
  • May show evidence of early bone ischemia

Management

• Nonsurgical
  • Considered ineffective at stopping progression of ischemia
  • Bedrest, limit weightbearing, pain control
• Medications
  • Bisphophonates, vasodilators, and anticoagulants have been used but efficacy has not yet been proven
• Surgical
  • Total Join Replacement
  • Unfortunately, patients with osteonecrosis have an increased failure rate of the procedure.
• Ongoing research for treatment
  • Joint preserving operations, Bone marrow decompression therapy, vascularized and nonvascularized bone grafts, Bone marrow grafting, and Osteotomy

Disposition

It is vital to order medical and orthopedic referrals for evaluation of comorbidities and evaluation of joint in the emergency department.

• Progression to subchondral collapse if the diagnosis is missed and untreated
  • 67% in asymptomatic patients
  • Greater than 85% in symptomatic patients
• In one study by the American Academy of Orthopaedic Surgeons, early detection and treatment with core decompression has shown to prevent the need for total hip replacement.

See Also

• Hip pain

References

• Kelly JD et al. Femoral head avascular necrosis treatment & management. Aug 16, 2015. http://emedicine.medscape.com/article/86568-treatment#showall.
• Miller MD M, Fisher MD S, Foran J. Osteonecrosis of the Hip. American Academy of Orthopaedic Surgeons. http://orthoinfo.aaos.org/topic.cfm?topic=a00216. Accessed August 2, 2016.
• Stoica Z et al. Imaging of Avascular Necrosis of Femoral Head: Familiar Methods and Newer Trends. Curr Health Sci J. 2009 Jan-Mar; 35(1): 23–28.
• Wainwright A. Legg-Calve-Perthes disease diagnostic tests - Epocrates online. Epocrates. https://online.epocrates.com/diseases/75134/Legg-Calve-Perthes-disease/Diagnostic-Tests. Accessed July 31, 2016.

Authors

Jesse Lee, Kevin Lu, Ross Donaldson, Jonathan Osgood, Daniel Ostermayer, Neil Young