Interaction Profile on Metallic Ions In Fracturing Waste

Title: Interaction Profile on Metallic Ions In Fracturing Waste

Subject of planned Report: The ATSDR interaction profile succinctly characterizes the toxicologic and adverse health effects for the substances being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): July 2017

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in 2018

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

1. Dale, Hattis

Academic and Professional Credentials	PhD
Current Position Title	Professor
Organizational Affiliation(s)	The George Perkins Marsh Institute Center for Toxicology, Environment, and Development Clark University, Worcester, MA
Areas of Expertise, Discipline, Relevant Experiences	Expertise and experience: use of various biomarkers and physiologically-based pharmacokinetic models to improve risk assessment for carcinogens; quantitative treatment of inter-individual variability in susceptibility for a wide variety of non-cancer effects; and use of Monte Carlo simulations to represent the combined effects of multiple sources of uncertainty and variability
Recommended by Scientific/Professional Society or General Public	No

2. Oswald, Robert E

Academic and Professional Credentials	PhD
Current Position Title	Professor
Organizational Affiliation(s)	Department of Population Health and Reproduction, School of Veterinary Medicine Department of Obstetrics and Gynecology, School of Medicine Center for Health and the Environment, University of California, Davis, CA
Areas of Expertise, Discipline, Relevant Experiences	Ovarian function, early pregnancy and comparative reproductive endocrinology, wildlife reproduction, comparative reproductive endocrinology, toxicology, epidemiology, reproduction of non-domestic species, endocrine aspect of female fertility and early pregnancy
Recommended by Scientific/Professional Society or General Public	No

3. Deziel, Nicole

Academic and Professional Credentials	PhD, MHS
Current Position Title	Assistant Professor of Epidemiology (Environmental Health)
Organizational Affiliation(s)	School of Public Health: Climate Change and Health; Deziel Lab, Environmental Health Sciences Yale Cancer Center: Cancer Prevention and Control Yale University, New Haven, CT 06520
Areas of Expertise, Discipline, Relevant Experiences	Expertise: interface between exposure to environmental agents and human disease, including women’s health and children’s health outcomes; pesticides, persistent organic pollutants, and polycyclic aromatic hydrocarbons. Research focus: evaluating, improving, and developing exposure estimates for application in environmental epidemiologic studies. Experience: critical methodologic issues, such as the relative contribution of different routes of exposure, between- and within-participant variability in exposure measurements over time, and surrogate exposure measures; how environmental exposures are changing with new techniques for energy production (e.g., hydraulic fracturing) and climate change.
Recommended by Scientific/Professional Society or General Public	No

4. Max, Costa

Academic and Professional Credentials	PhD
Current Position Title	Professor and Chair, Department of Environmental Medicine Professor, Department of Biochemistry and Molecular Pharmacology
Organizational Affiliation(s)	Department of Environmental Medicine New York University Medical Center Nelson Institute of Environmental Medicine Tuxedo, New York
Areas of Expertise, Discipline, Relevant Experiences	Expertise: molecular mechanisms of metal carcinogenesis, epigenetics, regulation of transcription, chromatin structure and dynamics, and pharmacology. Experience: over 300 publications; a recipient of Lifetime Achievement award from the Metals Specialty Section of the Society of Toxicology
Recommended by Scientific/Professional Society or General Public	No

Charge to Peer Reviewers: Charge to Peer Reviewers [PDF – 165 KB]

Additional elements to be added to the public posting as they become available