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Toxicological Profile for Uranium

Title: Toxicological Profile for Uranium

Subject of Planned Report: The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects for the substance being described.

Purpose of Planned Report: The purpose of the toxicological profile is to provide a source of toxicological and epidemiological data on hazardous substances most commonly found at hazardous waste sites and in support of public health assessments at these sites.

Type of Dissemination: ISI

Timing of Review (including deferrals): February 2011

Type of Review (panel, individual or alternative procedure): Individual

Opportunities for the Public to Comment (how and when): A draft of this profile will be made available for public comment in April 2011.

Peer Reviewers Provided with Public Comments before the Review: No

Anticipated Number of Reviewers: 3 or fewer

Primary Disciplines or Expertise: toxicology, environmental health, chemistry

Reviewers Selected by (agency or designated outside organization): CDC/ATSDR

Public Nominations Requested for Reviewers: No

Charge to Peer Reviewers: DTEM Charge to Peer Reviewers [PDF - 124 KB]

1. Fletcher F. Hahn

Academic and Professional Credentials

Ph.D., Comparative Pathology, University of California- Davis
D.V.M., Veterinary Medicine, Washington State University
B.S., Biological Sciences, Washington State University

Current Position Title

Scientist Emeritus

Organizational Affiliation(s)

Lovelace Respiratory Research Institute, Albuquerque, NM

Areas of Expertise, Discipline, Relevant Experiences

Dr. Hahn has extensive expertise in radiation, inhalation exposures, animal models, depleted uranium, and pulmonary toxicology.

Recommended by Scientific/Professional Society or General Public

No

2. Walter W. Piegorsch

Academic and Professional Credentials

Ph.D., Statistics, Cornell University
M.S., Statistics, Cornell University
B.A., Mathematics, Colgate University

Current Position Title

Chair, Graduate Interdisciplinary Program in Statistics

Organizational Affiliation(s)

University of Arizona, Tucson, AZ

Areas of Expertise, Discipline, Relevant Experiences

Dr. Piegorsch is a statistician with extensive experience analyzing environmental health data and application of benchmark dose modeling. He has knowledge of uranium and uranium compounds’ physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, and quantification of risk to humans.

Recommended by Scientific/Professional Society or General Public

No

3. Rudolfs K. Zalups


Academic and Professional Credentials

Ph.D., Human Anatomy and Cell Biology, University of Western Ontario
M.S., Zoology, State University of New York
B.S., Mathematics, State University of New York

Current Position Title

Professor, Histology

Organizational Affiliation(s)

Mercer University School of Medicine

Areas of Expertise, Discipline, Relevant Experiences

Dr. Zalups has expertise in the area of cellular and molecular biology and the toxiclogy of heavy metals such as uranium. Much of his work focuses on the mechanisms by which select environmental toxicants affect the kidneys.

Recommended by Scientific/Professional Society or General Public

No

Peer Reviewers’ Comments: Uranium Report [PDF - 4.45 MB]

CDC/ATSDR’s Response to Peer Reviewers’ Comments: Uranium Formal Disposition [PDF - 96 KB]

The ISI/HISA Dissemination Itself

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