We need you! Join our contributor community and become a WikEM editor through our open and transparent promotion process.
United States Antibiogram
From WikEM
(Redirected from Comparison of Antibacterial Spectra)
Contents
Gram Positives[1]
| Category | Organism | Strep. Group A, B, C, G | Strep. Pneumoniae | Viridans strep | Strep. anginosus gp | Enterococcus faecalis | Enterococcus faecium | MSSA | MRSA | CA-MRSA | Staph. Epidermidis | C. jeikeium | L. monocytogenes |
| Penicillins | Penicillin G | S | S | I | S | S | I | R | R | R | R | R | S |
| Penicillin V | S | S | I | S | S | I | R | R | R | R | R | R | |
| Anti-Staphylocccal Penicillins | Methicillin | S | S | I | S | R | R | S | R | R | S | R | R |
| Nafcillin/Oxacillin | S | S | I | S | R | R | S | R | R | S | R | R | |
| Cloxacillin/Diclox. | S | S | I | S | R | R | S | R | R | S | R | R | |
| Amino-Penicillins | AMP/Amox | S | S | I | S | S | I | R | R | R | R | R | S |
| Amox-Clav | S | S | I | S | S | S | S | R | R | R | R | X2 | |
| AMP-Sulb | S | S | I | S | S | S | S | R | R | R | R | S | |
| Anti-Pseudomonal Penicillins | Ticarcillin | S | S | I | S | I | I | R | R | R | I | R | S |
| Ticar-Clav | S | S | I | S | I | I | S | R | R | I | R | X2 | |
| Pip-Tazo | S | S | I | S | S | I | S | R | R | S | X1 | X2 | |
| Piperacillin | S | S | I | S | S | I | R | R | R | R | R | S | |
| Carbapenems | Doripenem | S | S | S | S | I | R | S | R | R | S | X1 | S |
| Ertapenem | S | S | S | S | R | R | S | R | R | S | R | I | |
| Imipenem | S | S | S | S | S | I | S | R | R | S | R | S | |
| Meropenem | S | S | S | S | I | R | S | R | R | S | X1 | S | |
| Aztreonam | R | R | R | R | R | R | R | R | R | R | R | R | |
| Fluroquinolones | Ciprofloxacin | I | I | R | R | U | R | S | R | I | S | R | S |
| Ofloxacin | I | I | R | R | U | R | S | R | X1 | S | R | R | |
| Pefloxacin | R | R | X1 | X1 | R | R | S | R | X1 | S | X1 | R | |
| Levofloxacin | S | S | S | S | S | R | S | R | I | S | X1 | S | |
| Moxifloxacin | S | S | S | S | S | I | S | I | I | S | X1 | S | |
| Gemifloxacin | S | S | S | S | S | I | S | I | I | S | X1 | S | |
| Gatifloxacin | S | S | S | S | S | I | S | I | I | S | X1 | S | |
| 1st G Cephalo | Cefazolin | S | S | S | X1 | R | X1 | S | R | R | I | R | R |
| 2nd G. Cephalo | Cefotetan | S | S | S | X1 | R | X1 | S | R | R | I | R | R |
| Cefoxitin | S | S | S | X1 | R | X1 | S | R | R | I | R | R | |
| Cefuroxime | S | S | S | X1 | R | X1 | S | R | R | I | R | R | |
| 3rd/4th G. Cephalo | Cefotaxime | S | S | S | X1 | R | X1 | S | R | R | I | R | R |
| Cefizoxime | S | S | S | X1 | R | X1 | S | R | R | I | R | R | |
| CefTRIAXone | S | S | S | X1 | R | X1 | S | R | R | I | R | R | |
| Ceftaroline | S | S | S | X1 | S | X1 | S | S | S | S | X1 | X1 | |
| CefTAZidime | S | S | I | X1 | R | X1 | I | R | R | I | R | R | |
| Cefepime | S | S | S | X1 | R | X1 | S | R | R | I | X1 | R | |
| Oral 1st G. Cephalo | Cefadroxil | S | S | S | X1 | R | X1 | S | R | R | I | R | R |
| Cephalexin | S | S | S | X1 | R | X1 | S | R | R | I | R | R | |
| Oral 2nd G. Cephalo | Cefaclor/Loracarbef | S | S | S | X1 | R | X1 | S | R | R | I | R | R |
| Cefproxil | S | S | R | X1 | R | X1 | S | R | R | I | R | R | |
| Cefuroxime axetil | S | S | S | X1 | R | X1 | S | R | R | I | R | R | |
| Oral 3rd G. Cephalo | Cefixime | S | S | S | X1 | R | X1 | R | R | R | R | R | R |
| Ceftibuten | S | I | R | X1 | R | X1 | R | R | R | R | R | R | |
| Cefpodox/Cefdinir/Cefditoren | S | S | S | X1 | R | X1 | S | R | R | I | X1 | R | |
| Aminoglycosides | Gentamicin | R | R | X1 | X1 | S | S | S | R | X1 | I | R | S |
| Tobramycin | R | R | X1 | X1 | S | R | S | R | X1 | I | R | S | |
| Amikacin | R | R | X1 | X1 | S | R | S | R | X1 | I | R | S | |
| Chloramphenicol | S | S | X1 | X1 | I | I | I | R | X1 | R | R | S | |
| Clindamycin | S | S | X1 | X1 | R | R | S | R | I | R | R | X1 | |
| Macrolides | Erythromycin | I | I | X1 | X1 | R | R | I | R | I | I | R | S |
| Azithromycin | I | I | X1 | X1 | R | R | S | R | I | R | R | S | |
| Clarithromycin | I | I | X1 | X1 | R | R | S | R | I | R | R | S | |
| Ketolide | Telithromycin | S | S | X1 | X1 | I | R | S | R | I | R | R | S |
| Tetracyclines | Doxycycline | I | S | X1 | X1 | R | R | I | I | S | R | R | S |
| Minocycline | S | S | X1 | X1 | R | R | S | I | S | R | R | S | |
| Glycylcycline | Tigecycline | S | S | X1 | X1 | S | S | S | S | S | S | S | S |
| Daptomycin | S | X23 | X1 | X1 | S | S | S | S | S | S | S | I | |
| Glyco/Lipoclycopeptides | Vancomycin | S | S | X1 | X1 | S | I | S | S | S | S | S | S |
| Teicoplanin | S | S | X1 | X1 | S | I | S | S | S | I | S | S | |
| Telavancin | S | S | X1 | X1 | S | S | S | S | S | S | S | S | |
| Fusidic Acid | I | I | X1 | X1 | S | X1 | S | S | S | S | S | X1 | |
| Trimethoprim | S | I | X1 | X1 | S | R | I | I | S | S | R | S | |
| TMP-SMX | X22 | S | X1 | X1 | X22 | R | S | S | S | I | R | S | |
| Urinary Agents | Nitrofurantoin | S | S | X1 | X1 | S | S | S | S | S | X1 | R | X1 |
| Fosfomycin | X1 | S | X1 | X1 | S | I | S | S | S | X1 | X1 | R | |
| Other | Rifampin | S | S | X1 | X1 | I | R | S | S | S | S | S | S |
| Metronidazole | R | R | X1 | X1 | R | R | R | R | R | R | R | R | |
| Quinupristin dalfoppristin | S | S | X1 | X1 | R | S | S | S | S | S | S | S | |
| Linezolid | S | S | X1 | X1 | S | S | S | S | S | S | S | S | |
| Colistimethate | R | R | X1 | X1 | R | R | R | R | R | R | R | R |
Gram Negatives
| Category | Organism | N. gonorrhoeae | N. meningitidis | Moraxella catarrhalis | H. influenzae | E. coli | Klebsiella sp | E. coli/Klebsiella ESBL+ | E coli/Klebsiella KPC+ | Enterobacter sp, AmpC neg | Enterobacter sp, AmpC pos | Serratia sp | Serratia marcescens | Salmonella sp | Shigella sp | Proteus mirabilis | Proteus vulgaris | Providencia sp. | Morganella sp. | Citrobacter freundii | Citrobacter diversus | Citrobacter sp. | Aeromonas sp | Acinetobacter sp. | Pseudomonas aeruginosa | Burkholderia cepacia | Stenotrophomonas maltophilia | Yersinia enterocolitica | Francisella tularensis | Brucella sp. | Legionella sp. | Pasteurella multocida | Haemophilus ducreyi | Vibrio vulnificus |
| Penicillins | Penicillin G | R | S | R | R | R | R | R | R | R | R | R | X1 | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | X1 | X1 | R | S | S | X1 |
| Penicillin V | R | R | R | R | R | R | R | R | R | R | R | X1 | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | X1 | X1 | R | S | X1 | X1 | |
| Anti-Staphylocccal Penicillins | Methicillin | R | R | R | R | R | R | R | R | R | R | R | X1 | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | X1 | X1 | R | R | X1 | X1 |
| Nafcillin/Oxacillin | R | R | R | R | R | R | R | R | R | R | R | X1 | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | X1 | X1 | R | R | X1 | X1 | |
| Cloxacillin/Diclox. | R | R | R | R | R | R | R | R | R | R | R | X1 | R | R | R | R | R | R | R | R | R | R | R | R | R | R | R | X1 | X1 | R | R | X1 | X1 | |
| Amino-Penicillins | AMP/Amox | R | S | R | I | I | R | R | R | R | R | R | X1 | I | I | S | R | R | R | R | R | R | R | R | R | R | R | R | X1 | X1 | R | S | R | X1 |
| Amox-Clav | S | S | S | S | S | S | R | R | R | R | R | X1 | S | S | S | S | S | I | R | R | R | S | R | R | R | R | I | X1 | X1 | R | S | S | X1 | |
| AMP-Sulb | S | S | S | S | S | S | R | R | R | R | R | X1 | S | S | S | S | S | S | R | R | R | S | S | R | R | R | I | X1 | X1 | R | S | S | X1 | |
| Anti-Pseudomonal Penicillins | Ticarcillin | X2 | S | R | I | I | R | R | R | S | S | R | X1 | S | S | S | S | S | S | S | S | S | S | R | S | R | X1 | I | X1 | X1 | R | S | X1 | X1 |
| Ticar-Clav | X2 | S | S | S | S | S | R | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | S | X1 | S | S | X1 | X1 | R | S | X1 | X1 | |
| Pip-Tazo | X2 | S | S | S | S | S | R | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | S | X1 | I | X1 | X1 | X1 | R | X1 | X1 | X1 | |
| Piperacillin | X2 | S | I | I | S | S | R | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | R | S | X1 | I | S | X1 | X1 | R | S | X1 | X1 | |
| Carbapenems | Doripenem | X2 | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | S | I | R | S | X1 | X1 | R | S | X1 | X1 |
| Ertapenem | X2 | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | R | R | R | R | X1 | X1 | X1 | R | S | X1 | X1 | |
| Imipenem | X2 | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | S | R | R | S | X1 | X1 | R | S | X1 | X1 | |
| Meropenem | X2 | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | S | S | R | X1 | X1 | X1 | R | X1 | X1 | X1 | |
| Aztreonam | S | S | S | S | S | S | R | R | S | S | S | X1 | X1 | S | S | S | S | S | S | S | S | S | R | S | R | R | S | X1 | X1 | R | S | X1 | X1 | |
| Fluroquinolones | Ciprofloxacin | I | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | S | R | R | S | X1 | X1 | S | S | X1 | X1 |
| Ofloxacin | I | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | I | R | R | S | X1 | X1 | S | S | X1 | X1 | |
| Pefloxacin | I | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | X1 | X1 | X1 | X1 | R | S | X1 | X1 | S | S | X1 | X1 | |
| Levofloxacin | I | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | I | X1 | I | S | X1 | X1 | S | S | X1 | X1 | |
| Moxifloxacin | I | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | I | R | I | S | X1 | X1 | S | S | X1 | X1 | |
| Gemifloxacin | I | X1 | S | S | S | S | S | R | S | S | X1 | X1 | X1 | X1 | X1 | S | X1 | X1 | X1 | X1 | X1 | X1 | I | X1 | X1 | X1 | X1 | X1 | X1 | S | X1 | X1 | X1 | |
| Gatifloxacin | I | S | S | S | S | S | S | R | S | S | S | X1 | S | S | S | S | S | S | S | S | S | S | I | I | R | I | S | X1 | X1 | S | S | X1 | X1 | |
| 1st G Cephalo | Cefazolin | S | R | I | S | S | S | R | R | R | R | R | X1 | X1 | X1 | S | R | R | R | R | R | R | R | R | R | R | R | R | X1 | X1 | R | X1 | X1 | X1 |
| 2nd G. Cephalo | Cefotetan | I | I | S | S | S | S | R | R | I | R | S | X1 | X1 | X1 | S | S | S | S | R | I | I | S | R | R | R | R | I | X1 | X1 | R | S | X1 | X1 |
| Cefoxitin | I | I | S | S | S | S | R | R | R | R | R | X1 | X1 | X1 | S | S | S | S | R | I | I | I | R | R | R | R | I | X1 | X1 | R | X1 | S | X1 | |
| Cefuroxime | I | S | S | S | S | S | R | R | I | R | R | X1 | X1 | X1 | S | S | R | I | R | I | I | S | R | R | R | R | I | X1 | X1 | R | S | X1 | X1 | |
| 3rd/4th G. Cephalo | Cefotaxime | I | S | S | S | S | S | R | R | S | R | S | X1 | S | S | S | S | S | S | S | S | S | S | R | R | I | R | S | X1 | X1 | R | S | S | X1 |
| Cefizoxime | I | I | S | S | S | S | R | R | S | R | S | X1 | S | S | S | S | S | S | R | S | S | S | R | R | I | R | S | X1 | X1 | R | S | S | X1 | |
| CefTRIAXone | I | S | S | S | S | S | R | R | S | R | S | X1 | S | S | S | S | S | S | S | S | S | S | R | R | I | R | S | X1 | X1 | R | S | S | X1 | |
| Ceftaroline | I | S | S | S | S | S | R | R | S | R | S | X1 | S | S | S | S | S | S | X1 | S | S | S | X1 | R | R | R | X1 | X1 | X1 | R | X1 | X1 | X1 | |
| CefTAZidime | I | I | S | S | S | S | R | R | S | R | S | X1 | S | S | S | S | S | S | R | S | S | S | I | S | S | I | I | X1 | X1 | R | X1 | S | X1 | |
| Cefepime | I | S | S | S | S | S | R | R | S | R | S | X1 | S | S | S | S | S | S | S | S | S | S | I | S | I | R | S | X1 | X1 | R | S | X1 | X1 | |
| Oral 1st G. Cephalo | Cefadroxil | R | R | R | X1 | S | S | R | R | R | R | R | X1 | R | R | S | R | R | R | R | R | X1 | X1 | R | R | R | R | X1 | X1 | X1 | R | X1 | X1 | X1 |
| Cephalexin | R | R | R | R | S | S | R | R | R | R | R | X1 | R | R | S | R | R | R | R | R | R | X1 | R | R | R | R | X1 | X1 | X1 | R | R | X1 | X1 | |
| Oral 2nd G. Cephalo | Cefaclor/Loracarbef | I | I | I | S | S | S | R | R | R | R | R | X1 | X1 | X1 | S | R | R | R | R | R | I | X1 | R | R | R | R | X1 | X1 | X1 | R | X1 | X1 | X1 |
| Cefproxil | I | I | S | S | S | S | R | R | R | R | R | X1 | X1 | X1 | S | R | R | R | R | R | R | X1 | R | R | R | R | X1 | X1 | X1 | R | X1 | X1 | X1 | |
| Cefuroxime axetil | I | I | S | S | S | S | R | R | R | R | R | X1 | X1 | X1 | S | R | S | I | R | X1 | I | X1 | R | R | R | R | X1 | X1 | X1 | R | X1 | X1 | X1 | |
| Oral 3rd G. Cephalo | Cefixime | S | I | S | S | S | S | R | R | R | R | I | X1 | S | S | S | S | S | R | R | X1 | S | S | R | R | R | R | S | X1 | X1 | R | S | S | X1 |
| Ceftibuten | I | I | S | S | S | S | R | R | I | R | I | X1 | S | S | S | S | S | R | R | S | S | S | R | R | S | R | S | X1 | X1 | R | X1 | X1 | X1 | |
| Cefpodox/Cefdinir/Cefditoren | S | X1 | S | S | S | S | R | R | R | R | R | X1 | S | S | S | I | X1 | R | R | X1 | S | X1 | X1 | R | X1 | X1 | X1 | X1 | X1 | R | S | X1 | X1 | |
| Aminoglycosides | Gentamicin | R | R | S | S | S | S | S | R | S | S | X1 | S | X1 | S | X1 | S | X1 | X1 | X1 | X1 | X1 | X1 | R | S | R | R | S | S | S+ | X1 | X1 | X1 | I |
| Tobramycin | R | R | S | S | S | S | S | R | S | S | X1 | S | X1 | S | X1 | S | X1 | X1 | X1 | X1 | X1 | X1 | R | S | R | R | S | S | S+ | X1 | X1 | X1 | I | |
| Amikacin | R | R | S | S | S | S | S | R | S | S | X1 | S | X1 | S | X1 | S | X1 | X1 | X1 | X1 | X1 | X1 | I | S | R | R | S | S | S+ | X1 | X1 | X1 | I | |
| Chloramphenicol | S | S | S | S | S | I | I | R | R | R | X1 | R | S | S | X1 | I | X1 | X1 | X1 | X1 | X1 | X1 | R | R | S | S | S | S | S | X1 | X1 | X2 | X2 | |
| Clindamycin | R | R | R | R | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | X1 | R | X1 | X1 | X2 | X1 | |
| Macrolides | Erythromycin | I | X2 | I | I | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | X1 | R | S | X1 | S | X1 |
| Azithromycin | I | X2 | S | S | R | R | R | R | R | R | X1 | R | I | I | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | X1 | R | S | X1 | S | X1 | |
| Clarithromycin | I | X1 | S | S | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | X1 | R | S | X1 | X1 | X1 | |
| Ketolide | Telithromycin | X2 | X2 | S | S | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | X1 | R | X2 | X1 | X1 | X1 |
| Tetracyclines | Doxycycline | I | S | S | S | S | I | I | R | R | R | X1 | R | I | I | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | X2 | R | S | S | X2 | X1 | R | S+ |
| Minocycline | I | S | S | S | S | I | I | R | R | R | X1 | R | I | I | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | S | R | I | R | R | X1 | S | X2 | X1 | R | S+ | |
| Glycylcycline | Tigecycline | X2 | X1 | S | S | S | S | S | S | S | S | X1 | S | S | S | X1 | I | X1 | X1 | X1 | X1 | X1 | X1 | I | R | I | S | X1 | X1 | X1 | X2 | X1 | X1 | X1 |
| Daptomycin | R | R | R | R | R | R | R | R | R | R | X1 | R | R | X1 | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | R | R | R | X1 | R | R | |
| Glyco/Lipoclycopeptides | Vancomycin | R | R | X1 | X1 | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | X1 | X1 | R | X1 | X1 | R | X1 |
| Teicoplanin | R | R | X1 | X1 | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | X1 | X1 | R | X1 | X1 | X1 | X1 | |
| Telavancin | R | R | X1 | X1 | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | X1 | X1 | R | X1 | X1 | X1 | X1 | |
| Fusidic Acid | S | S | X1 | X1 | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | X1 | X1 | I | X1 | X1 | R | |
| Trimethoprim | R | I | X1 | I | S | I | I | R | I | I | X1 | R | I | I | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | S | R | X1 | X1 | X2 | S | X1 | R | X1 | |
| TMP-SMX | I | X2 | S | I | I | I | I | R | X1 | X1 | X1 | I | I | I | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | I | R | S | S | S | S | X2 | S | X1 | I | X1 | |
| Urinary Agents | Nitrofurantoin | S | X1 | X1 | X1 | S | I | X1 | R | I | I | X1 | R | S | S | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | X1 | X1 | X1 | X1 | X1 | X1 | X1 |
| Fosfomycin | X1 | X1 | X1 | X1 | S | S | S | S | S | S | X1 | S | S | X1 | X1 | S | X1 | X1 | X1 | X1 | X1 | X1 | R | R | X1 | X1 | X1 | X1 | X1 | X1 | X1 | X1 | X1 | |
| Other | Rifampin | X2 | S | S | S | R | R | R | I | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | X1 | X1 | S | S+ | X1 | X1 | X1 | X1 |
| Metronidazole | R | R | R | R | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | R | R | R | X1 | R | R | |
| Quinupristin dalfoppristin | X2 | R | S | I | R | R | R | R | R | R | X1 | X1 | R | R | X1 | X1 | X1 | X1 | X1 | X1 | X1 | X1 | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | X1 | X1 | X1 | |
| Linezolid | X1 | R | I | I | R | R | R | R | R | R | X1 | R | R | R | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | R | R | R | R | R | R | R | X1 | X1 | X1 | X1 | |
| Colistimethate | R | R | X1 | X1 | S | S | S | S | S | S | X1 | R | X1 | X1 | X1 | R | X1 | X1 | X1 | X1 | X1 | X1 | S | S | R | I | X1 | X1 | X1 | X1 | X1 | X1 | X1 |
Non-Culture Growing Bacteria (Misc)
| Category | Organism | Chlamydophila sp | Mycoplasm pneumoniae | Rickettsia sp | Mycobacterium avium |
| Penicillins | Penicillin G | R | R | X1 | X1 |
| Penicillin V | R | R | X1 | X1 | |
| Anti-Staphylocccal Penicillins | Methicillin | R | R | X1 | X1 |
| Nafcillin/Oxacillin | R | R | X1 | X1 | |
| Cloxacillin/Diclox. | R | R | X1 | X1 | |
| Amino-Penicillins | AMP/Amox | R | R | X1 | X1 |
| Amox-Clav | R | R | X1 | X1 | |
| AMP-Sulb | R | R | X1 | X1 | |
| Anti-Pseudomonal Penicillins | Ticarcillin | R | R | X1 | X1 |
| Ticar-Clav | R | R | X1 | X1 | |
| Pip-Tazo | R | R | X1 | X1 | |
| Piperacillin | R | R | X1 | X1 | |
| Carbapenems | Doripenem | R | R | X1 | X1 |
| Ertapenem | R | R | X1 | X1 | |
| Imipenem | R | R | X1 | X1 | |
| Meropenem | R | R | X1 | X1 | |
| Aztreonam | R | R | X1 | X1 | |
| Fluroquinolones | Ciprofloxacin | S | S | X1 | X1 |
| Ofloxacin | S | S | X1 | X1 | |
| Pefloxacin | S | S | X1 | X1 | |
| Levofloxacin | S | S | X1 | X1 | |
| Moxifloxacin | S | S | X1 | X1 | |
| Gemifloxacin | S | S | X1 | X1 | |
| Gatifloxacin | S | S | X1 | X1 | |
| 1st G Cephalo | Cefazolin | X1 | X1 | X1 | X1 |
| 2nd G. Cephalo | Cefotetan | X1 | X1 | X1 | X1 |
| Cefoxitin | X1 | X1 | X1 | X1 | |
| Cefuroxime | X1 | X1 | X1 | X1 | |
| 3rd/4th G. Cephalo | Cefotaxime | X1 | X1 | X1 | X1 |
| Cefizoxime | X1 | X1 | X1 | X1 | |
| CefTRIAXone | X1 | X1 | X1 | X1 | |
| Ceftaroline | X1 | X1 | X1 | X1 | |
| CefTAZidime | X1 | X1 | X1 | X1 | |
| Cefepime | X1 | X1 | X1 | X1 | |
| Oral 1st G. Cephalo | Cefadroxil | X1 | X1 | X1 | X1 |
| Cephalexin | X1 | X1 | X1 | X1 | |
| Oral 2nd G. Cephalo | Cefaclor/Loracarbef | X1 | X1 | X1 | X1 |
| Cefproxil | X1 | X1 | X1 | X1 | |
| Cefuroxime axetil | X1 | X1 | X1 | X1 | |
| Oral 3rd G. Cephalo | Cefixime | X1 | X1 | X1 | X1 |
| Ceftibuten | X1 | X1 | X1 | X1 | |
| Cefpodox/Cefdinir/Cefditoren | X1 | X1 | X1 | X1 | |
| Aminoglycosides | Gentamicin | R | R | R | X1 |
| Tobramycin | R | R | R | X1 | |
| Amikacin | R | R | R | S | |
| Chloramphenicol | S | S | S | X1 | |
| Clindamycin | I | R | X1 | X1 | |
| Macrolides | Erythromycin | S | S | I | X1 |
| Azithromycin | S | S | X1 | S | |
| Clarithromycin | S | S | X1 | S | |
| Ketolide | Telithromycin | S | S | S | X1 |
| Tetracyclines | Doxycycline | S | S | S | R |
| Minocycline | S | S | S | R | |
| Glycylcycline | Tigecycline | S | S | X1 | R |
| Daptomycin | X1 | X1 | X1 | X1 | |
| Glyco/Lipoclycopeptides | Vancomycin | X1 | X1 | R | X1 |
| Teicoplanin | X1 | X1 | R | X1 | |
| Telavancin | X1 | X1 | R | X1 | |
| Fusidic Acid | R | R | R | X1 | |
| Trimethoprim | R | X1 | X1 | X1 | |
| TMP-SMX | X1 | X1 | X1 | X1 | |
| Urinary Agents | Nitrofurantoin | R | X1 | X1 | X1 |
| Fosfomycin | X1 | X1 | X1 | X1 | |
| Other | Rifampin | X2 | X1 | X1 | X1 |
| Metronidazole | R | R | R | R | |
| Quinupristin dalfoppristin | X2 | S | X1 | R | |
| Linezolid | X2 | R | X1 | R | |
| Colistimethate | X1 | X1 | X1 | X1 |
Anaerobes
| Category | Organism | Actinomyces | Bacteroides fragilis | Prevotella melaninogenica | Clostridium difficile | Clostridium (not difficile) | Fusobacterium necrophorum | Peptostreptococcus sp. |
| Penicillins | Penicillin G | S | R | S | X2 | S | I | S |
| Penicillin V | I | I | R | X1 | S | I | S | |
| Anti-Staphylocccal Penicillins | Methicillin | R | R | R | X1 | X1 | X1 | S |
| Nafcillin/Oxacillin | R | R | R | X1 | X1 | X1 | S | |
| Cloxacillin/Diclox. | R | R | R | X1 | X1 | X1 | S | |
| Amino-Penicillins | AMP/Amox | S | R | S | X1 | S | S | S |
| Amox-Clav | S | S | S | X1 | S | S | S | |
| AMP-Sulb | S | S | S | X2 | S | S | S | |
| Anti-Pseudomonal Penicillins | Ticarcillin | X1 | R | S | X1 | S | X1 | S |
| Ticar-Clav | X1 | S | S | X1 | S | S | S | |
| Pip-Tazo | X1 | S | S | X1 | S | S | S | |
| Piperacillin | S | R | S | X2 | S | X1 | S | |
| Carbapenems | Doripenem | X1 | S | S | X2 | S | S | S |
| Ertapenem | S | S | S | X2 | S | S | S | |
| Imipenem | S | S | S | X2 | S | S | S | |
| Meropenem | X1 | S | S | X2 | S | S | S | |
| Aztreonam | R | R | R | R | R | X1 | R | |
| Fluroquinolones | Ciprofloxacin | R | R | R | R | I | X1 | I |
| Ofloxacin | I | R | I | X1 | I | X1 | I | |
| Pefloxacin | X1 | R | X1 | X1 | X1 | X1 | X1 | |
| Levofloxacin | X1 | R | S | R | S | X1 | S | |
| Moxifloxacin | S | I | S | R | I | I | S | |
| Gemifloxacin | X1 | R | X1 | X1 | X1 | X1 | X1 | |
| Gatifloxacin | S | I | S | R | S | X1 | S | |
| 1st G Cephalo | Cefazolin | X1 | R | X1 | X1 | X1 | X1 | X1 |
| 2nd G. Cephalo | Cefotetan | X1 | I | S | X1 | S | X1 | S |
| Cefoxitin | X1 | S | S | R | S | S | S | |
| Cefuroxime | X1 | R | S | X1 | S | X1 | S | |
| 3rd/4th G. Cephalo | Cefotaxime | X1 | R | S | R | S | X1 | S |
| Cefizoxime | S | I | S | R | S | X1 | S | |
| CefTRIAXone | S | R | I | X1 | S | X1 | S | |
| Ceftaroline | X1 | R | X1 | X1 | X1 | X1 | X1 | |
| CefTAZidime | X1 | R | S | X1 | S | X1 | S | |
| Cefepime | X1 | R | R | R | X1 | X1 | S | |
| Oral 1st G. Cephalo | Cefadroxil | X1 | X1 | X1 | X1 | X1 | X1 | X1 |
| Cephalexin | X1 | R | X1 | X1 | X1 | X1 | S | |
| Oral 2nd G. Cephalo | Cefaclor/Loracarbef | X1 | R | S | X1 | X1 | X1 | S |
| Cefproxil | X1 | R | S | X1 | S | X1 | S | |
| Cefuroxime axetil | X1 | R | S | X1 | S | X1 | S | |
| Oral 3rd G. Cephalo | Cefixime | X1 | R | S | X1 | R | X1 | S |
| Ceftibuten | X1 | R | X1 | X1 | X1 | X1 | X1 | |
| Cefpodox/Cefdinir/Cefditoren | X1 | X1 | X1 | X1 | X1 | X1 | X1 | |
| Aminoglycosides | Gentamicin | R | R | R | R | X1 | R | R |
| Tobramycin | R | R | R | R | X1 | R | R | |
| Amikacin | R | R | R | R | X1 | R | R | |
| Chloramphenicol | X2 | X2 | S | I | S | S | S | |
| Clindamycin | S | I | S | X1 | I | S | S | |
| Macrolides | Erythromycin | S | R | X1 | X1 | I | R | I |
| Azithromycin | S | R | S | X1 | S | R | S | |
| Clarithromycin | S | R | S | X1 | S | R | I | |
| Ketolide | Telithromycin | X1 | X1 | X1 | X1 | X1 | X1 | S |
| Tetracyclines | Doxycycline | S | I | S | X1 | S | X1 | S |
| Minocycline | S | I | S | X1 | S | X1 | S | |
| Glycylcycline | Tigecycline | X1 | S | S | X1 | S | S | S |
| Daptomycin | X1 | X1 | X1 | X1 | X1 | X1 | X1 | |
| Glyco/Lipoclycopeptides | Vancomycin | S | R | R | S | S | X1 | S |
| Teicoplanin | X1 | X1 | X1 | S | S | X1 | S | |
| Telavancin | S | R | R | S | S | X1 | S | |
| Fusidic Acid | S | X1 | S | X1 | S | X1 | S | |
| Trimethoprim | X1 | X2 | X1 | X1 | X1 | X1 | X1 | |
| TMP-SMX | X1 | R | X1 | X1 | X1 | X1 | X1 | |
| Urinary Agents | Nitrofurantoin | X1 | X1 | X1 | X1 | X1 | X1 | X1 |
| Fosfomycin | X1 | X1 | X1 | X1 | X1 | X1 | X1 | |
| Other | Rifampin | X1 | X1 | X1 | X1 | X1 | X1 | X1 |
| Metronidazole | R | S | S | S | S+ | S | I | |
| Quinupristin dalfoppristin | X1 | X1 | S | I | X2 | X1 | X1 | |
| Linezolid | X1 | I | X1 | I | X2 | X1 | S | |
| Colistimethate | X1 | X1 | X1 | X1 | X1 | X1 | X1 |
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
| ||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
See Also
External Links
References
- ↑ Sanford Guide to Antimicrobial Therapy 2014
